Glioma initiating cells form a differentiation niche via the induction of extracellular matrices and integrin αV.

Autor: Akiko Niibori-Nambu, Uichi Midorikawa, Souhei Mizuguchi, Takuichiro Hide, Minako Nagai, Yoshihiro Komohara, Megumi Nagayama, Mio Hirayama, Daiki Kobayashi, Nobuyuki Tsubota, Tatsuya Takezaki, Keishi Makino, Hideo Nakamura, Motohiro Takeya, Junichi Kuratsu, Norie Araki

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e59558 (2013)

Glioma initiating cells (GICs) are considered responsible for the therapeutic resistance and recurrence of malignant glioma. To clarify the molecular mechanism of GIC maintenance/differentiation, we established GIC clones having the potential to diff

Externí odkaz: https://doaj.org/article/29e00a437c104327844d8651cc075cb4

Involvement of an Orphan Transporter, SLC22A18, in Cell Growth and Drug Resistance of Human Breast Cancer MCF7 Cells

Autor: Mio Hirayama-Kurogi, Shingo Ito, Yu Fujino, Seiryo Ogata, Sumio Ohtsuki

Publikováno v: Journal of Pharmaceutical Sciences. 107:3163-3170

The SLC22A18 gene, which encodes an orphan transporter, is located at the 11p15.5 imprinted region, an important tumor suppressor gene region. However, the role of SLC22A18 in tumor suppression remains unclear. Here, we investigated the involvement o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e07311b93e461e5db0b011dfe7a6d17
https://doi.org/10.1016/j.xphs.2018.08.011

Large-Scale Quantitative Comparison of Plasma Transmembrane Proteins between Two Human Blood-Brain Barrier Model Cell Lines, hCMEC/D3 and HBMEC/ciβ

Autor: Takeshi Masuda, Pierre-Olivier Couraud, Mio Hirayama-Kurogi, Tomomi Furihata, Arisu Furukawa, Toshiki Hoshiyama, Sumio Ohtsuki, Tatsuki Uemura, Shingo Ito, Seiryo Ogata

Publikováno v: Molecular pharmaceutics. 16(5)

Transmembrane (TM) proteins localized at the plasma membrane, such as transporters and receptors, play important roles in regulating the selective permeability of the blood-brain barrier (BBB). The purpose of the present study was to clarify the diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8936e1f40941525bb551994ae21449
https://pubmed.ncbi.nlm.nih.gov/30983357

Identification of a Specific Translational Machinery via TCTP–EF1A2 Interaction Regulating NF1-associated Tumor Growth by Affinity Purification and Data-independent Mass Spectrometry Acquisition (AP-DIA)

Autor: Hiroki Okanishi, Takaho Tokuda, Kyosuke Sato, Megumi Nagayama, Sumio Ohtsuki, Daiki Kobayashi, Mio Hirayama-Kurogi, Norie Araki

Neurofibromatosis type 1 (NF1) is an autosomal dominant disease that predisposes individuals to developing benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). The mechanism of NF1-tumorigenesis or the curatives have not been es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64617767d3fbf7a4c7093842d1c33790
https://europepmc.org/articles/PMC6356078/

Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

Autor: Yansheng Liu, Brett Larsen, Guixue Hou, Bradford W. Gibson, George Rosenberger, Mark P. Molloy, Christie L. Hunter, Ruedi Aebersold, Liang Lin, Siqi Liu, Ben C. Collins, Birgit Schilling, Stefani N. Thomas, Sumio Ohtsuki, Robert L. Moritz, Hui Zhang, Jason M. Held, Nathalie Selevsek, Ralph Schlapbach, Christoph Krisp, Daniel W. Chan, Shin-Cheng Tzeng, Anne-Claude Gingras, Samuel L. Bader, Mio Hirayama-Kurogi

Publikováno v: Collins, B C, Hunter, C L, Liu, Y, Schilling, B, Rosenberger, G, Bader, S L, Chan, D W, Gibson, B W, Gingras, A-C, Held, J M, Hirayama-Kurogi, M, Hou, G, Krisp, C, Larsen, B, Lin, L, Liu, S, Molloy, M P, Moritz, R L, Ohtsuki, S, Schlapbach, R, Selevsek, N, Thomas, S N, Tzeng, S-C, Zhang, H & Aebersold, R 2017, ' Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry ', Nature Communications, vol. 8, no. 1, 291 . https://doi.org/10.1038/s41467-017-00249-5
Nature Communications, 8
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications

Quantitative proteomics employing mass spectrometry is an indispensable tool in life science research. Targeted proteomics has emerged as a powerful approach for reproducible quantification but is limited in the number of proteins quantified. SWATH-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62523cd15b09e35f4101f977700d9418
https://pure.qub.ac.uk/en/publications/multilaboratory-assessment-of-reproducibility-qualitative-and-quantitative-performance-of-swathmass-spectrometry(caaee58f-1235-4cb0-a4c3-9fde25ea2629).html