Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mio Harachi"'
Autor:
Mio Harachi, Kenta Masui, Erika Shimizu, Kumiko Murakami, Hiromi Onizuka, Yoshihiro Muragaki, Takakazu Kawamata, Hisako Nakayama, Mariko Miyata, Takashi Komori, Webster K. Cavenee, Paul S. Mischel, Atsushi Kurata, Noriyuki Shibata
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global “hypomethylator phenotype”, are associated with cancer. Here we show that an underlying mechanism for this phenotype in the
Externí odkaz:
https://doaj.org/article/59ba976a12834ee782df85c5cc6333ba
Autor:
Hiroki Sugishita, Takashi Kondo, Shinsuke Ito, Manabu Nakayama, Nayuta Yakushiji-Kaminatsui, Eiryo Kawakami, Yoko Koseki, Yasuhide Ohinata, Jafar Sharif, Mio Harachi, Neil P. Blackledge, Robert J. Klose, Haruhiko Koseki
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Polycomb repressive complexes (PRC1 and PRC2) repress genes that are crucial for development via epigenetic modifications; however, their role in differentiation is not well known. Here the authors reveal that a PCGF1-containing PRC1 variant facilita
Externí odkaz:
https://doaj.org/article/dee9c656f1d944dab8edc3fb703eee1f
Publikováno v:
Metabolites, Vol 11, Iss 4, p 216 (2021)
Metabolic reprogramming is an emerging hallmark of cancer and is driven by abnormalities of oncogenes and tumor suppressors. Accelerated metabolism causes cancer cell aggression through the dysregulation of rate-limiting metabolic enzymes as well as
Externí odkaz:
https://doaj.org/article/cb28c62a10c14f81afa227f81d1e15b1
Autor:
Noriyuki Shibata, Paul S. Mischel, Webster K. Cavenee, Takakazu Kawamata, Yoshihiro Muragaki, Hiroaki Honda, Kenta Masui, Mio Harachi
Figure S1. mTORC1 and mTORC2 are activated downstream of aberrant EGFR signaling in human GBM. Figure S2. mTOR complexes regulate expression of EZH2 and H3K27me3 in GBM cell lines and other types of cancer cell lines. Figure S3. EGFR activation trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c355ea05324dda6353983d1c194a2e
https://doi.org/10.1158/1541-7786.22516662.v1
https://doi.org/10.1158/1541-7786.22516662.v1
Autor:
Noriyuki Shibata, Paul S. Mischel, Webster K. Cavenee, Takakazu Kawamata, Yoshihiro Muragaki, Hiroaki Honda, Kenta Masui, Mio Harachi
Epigenetic regulation known for DNA methylation and histone modification is critical for securing proper gene expression and chromosomal function, and its aberration induces various pathologic conditions including cancer. Trimethylation of histone H3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2545389002c8a5d6b3618b0f0ae664e0
https://doi.org/10.1158/1541-7786.c.6541437.v1
https://doi.org/10.1158/1541-7786.c.6541437.v1
Autor:
Paul S. Mischel, Huijun Yang, Yoshihiro Muragaki, Shiro Ikegami, Takakazu Kawamata, Nobutaka Arai, Webster K. Cavenee, Noriyuki Shibata, Hiromi Onizuka, Timothy F. Cloughesy, Mio Harachi, Takashi Komori, Kenta Masui, William H. Yong
Publikováno v:
J Biol Chem
In cancer, aberrant growth factor receptor signaling reprograms cellular metabolism and global gene transcription to drive aggressive growth, but the underlying mechanisms are not well-understood. Here we show that in the highly lethal brain tumor gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735276b28a0ab48351428f89e33398e8
https://doi.org/10.1074/jbc.ra119.011519
https://doi.org/10.1074/jbc.ra119.011519
Publikováno v:
Metabolites
Metabolites, Vol 11, Iss 216, p 216 (2021)
Metabolites, Vol 11, Iss 216, p 216 (2021)
Metabolic reprogramming is an emerging hallmark of cancer and is driven by abnormalities of oncogenes and tumor suppressors. Accelerated metabolism causes cancer cell aggression through the dysregulation of rate-limiting metabolic enzymes as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22bee14aaa76d98236903d47a3deee15
https://pubmed.ncbi.nlm.nih.gov/33916219
https://pubmed.ncbi.nlm.nih.gov/33916219
Autor:
Haruhiko Koseki, Yasuhide Ohinata, Jafar Sharif, Manabu Nakayama, Mio Harachi, Takashi Kondo, Neil P. Blackledge, Nayuta Yakushiji-Kaminatsui, Yoko Koseki, Shinsuke Ito, Robert J. Klose, Hiroki Sugishita, Eiryo Kawakami
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Polycomb repressive complexes-1 and -2 (PRC1 and 2) silence developmental genes in a spatiotemporal manner during embryogenesis. How Polycomb group (PcG) proteins orchestrate down-regulation of target genes upon differentiation, however, remains elus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9537eb131b0a3c3378984d539d5db5d
https://pubmed.ncbi.nlm.nih.gov/34504070
https://pubmed.ncbi.nlm.nih.gov/34504070
Autor:
Yoshihiro Muragaki, Webster K. Cavenee, Takakazu Kawamata, Noriyuki Shibata, Hiroaki Honda, Paul S. Mischel, Kenta Masui, Mio Harachi
Publikováno v:
Molecular cancer research : MCR. 18(8)
Epigenetic regulation known for DNA methylation and histone modification is critical for securing proper gene expression and chromosomal function, and its aberration induces various pathologic conditions including cancer. Trimethylation of histone H3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1035f2165925d973117daefd9dd095eb
https://pubmed.ncbi.nlm.nih.gov/32366675
https://pubmed.ncbi.nlm.nih.gov/32366675
Publikováno v:
Neuro-oncology Advances
Trimethylation of histone H3 on lysine 27 (H3K27me3) is essential for ensuring proper gene expression and chromosomal function, and its aberration is associated with the pathogenesis of various brain tumors. However, it remains unclear how histone me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea75a248691d9faf8e2d8bc5d896b1f
https://doi.org/10.1093/noajnl/vdaa143.022
https://doi.org/10.1093/noajnl/vdaa143.022