Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Minzhu Xie"'
Autor:
Junjun Zhang, Minzhu Xie
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-24 (2023)
Abstract Background Identifying drug–target interactions (DTIs) plays a key role in drug development. Traditional wet experiments to identify DTIs are costly and time consuming. Effective computational methods to predict DTIs are useful to speed up
Externí odkaz:
https://doaj.org/article/bc857e5370954f2c8f7717301677d9c3
Autor:
Junjun Zhang, Minzhu Xie
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-20 (2022)
Abstract Background Identifying drug–target interactions (DTIs) plays a key role in drug development. Traditional wet experiments to identify DTIs are expensive and time consuming. Effective computational methods to predict DTIs are useful to narro
Externí odkaz:
https://doaj.org/article/ebcbd44ff3604baaba079cc30c3257e8
Publikováno v:
BMC Bioinformatics, Vol 23, Iss S8, Pp 1-13 (2022)
Abstract Background Knowing the responses of a patient to drugs is essential to make personalized medicine practical. Since the current clinical drug response experiments are time-consuming and expensive, utilizing human genomic information and drug
Externí odkaz:
https://doaj.org/article/120eeed9390a42029892721e7c677d0b
Autor:
Junjun Zhang, Minzhu Xie
Publikováno v:
IEEE Access, Vol 10, Pp 91235-91244 (2022)
Accurate drug-target interactions (DTIs) prediction can significantly speed up the process of new drug design and development. Recently, many matrix factorization methods have been used to predict DTIs. However, most of them use heuristic and iterati
Externí odkaz:
https://doaj.org/article/16e269c4f60248b6a17bcc162b17f1e6
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
It is well known that histone modifications play an important part in various chromatin-dependent processes such as DNA replication, repair, and transcription. Using computational models to predict gene expression based on histone modifications has b
Externí odkaz:
https://doaj.org/article/263415bbc71d489fa7d5b2ad5da1c567
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Increasing evidences show that the abnormal microRNA (miRNA) expression is related to a variety of complex human diseases. However, the current biological experiments to determine miRNA-disease associations are time consuming and expensive. Therefore
Externí odkaz:
https://doaj.org/article/48e6861ffe38442d8b68bb41019d41f3
Autor:
Jiancheng Zhong, Chao Tang, Wei Peng, Minzhu Xie, Yusui Sun, Qiang Tang, Qiu Xiao, Jiahong Yang
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Some proposed methods for identifying essential proteins have better results by using biological information. Gene expression data is generally used to identify essential proteins. However, gene expression data is prone to fluctua
Externí odkaz:
https://doaj.org/article/3ae4a39cadd1442888d3968af522379e
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-22 (2021)
Abstract Background Long non-coding RNAs (lncRNAs) regulate diverse biological processes via interactions with proteins. Since the experimental methods to identify these interactions are expensive and time-consuming, many computational methods have b
Externí odkaz:
https://doaj.org/article/fb068e89cda14994ad02b5b5334e8acf
Publikováno v:
IEEE Access, Vol 7, Pp 140224-140232 (2019)
Using molecular profiles to predict the drug response is of practical importance in precision medicine and have been extensively studied. Due to the complexity of molecular information, the existing methods couldn't capture enough information and the
Externí odkaz:
https://doaj.org/article/77b4490c44a24e74b25759e82cd6f546
Publikováno v:
Results in Physics, Vol 17, Iss , Pp 103035- (2020)
A tunable mid-infrared refractive index sensor consisting of bulk-Dirac-semimetal (BDS) and one-dimensional photonic crystals (1DPC) is proposed. This sensor has high angular sensitivity and ultra-high figure-of-merit (FOM), which is attributed to th
Externí odkaz:
https://doaj.org/article/3d4fb38b50854d96b9fc5c8713b83c70