Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Minu Chaudhuri"'
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 249 (2024)
Sterol biosynthesis via the mevalonate-isoprenoid pathway produces ergosterol (24β-methyl cholesta-5,7-dienol) necessary for growth in a wide-range of eukaryotic pathogenic organisms in eukaryotes, including the fungi, trypanosomes and amoebae, whil
Externí odkaz:
https://doaj.org/article/32268203d6b44c92945cf415e8ba7261
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background We have previously shown that the zinc finger transcription repressor SNAI2 (SLUG) represses tumor suppressor BRCA2-expression in non-dividing cells by binding to the E2-box upstream of the transcription start site. However, it is
Externí odkaz:
https://doaj.org/article/d1abf39e4e9f4a43b2d1bdc6d9beeb63
Autor:
Anuj Tripathi, Ujjal K. Singha, Ayorinde Cooley, Taneisha Gillyard, Evan Krystofiak, Siddharth Pratap, Jamaine Davis, Minu Chaudhuri
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
African trypanosomiasis is a neglected tropical disease caused by the parasitic protozoan Trypanosoma bruceiT. bruceiT. brucei
Externí odkaz:
https://doaj.org/article/fc95da10597f40c999c66d146eaaba1a
Autor:
Wenxu Zhou, Emilio Ramos, Xunlu Zhu, Paxtyn M. Fisher, Medhanie E. Kidane, Boden H. Vanderloop, Crista D. Thomas, Juqiang Yan, Ujjal Singha, Minu Chaudhuri, Michael T. Nagel, W.David Nes
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 5, Pp 981-994 (2019)
Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT). Here, we isolated natural suicide substrates of the ergosterol
Externí odkaz:
https://doaj.org/article/09be2b3fa76c4660b95ac736ad3c5f60
Publikováno v:
Molecules, Vol 27, Iss 13, p 4088 (2022)
Trypanosoma brucei, the causative agent for human African trypanosomiasis, is an emerging ergosterol-dependent parasite that produces chokepoint enzymes, sterol methyltransferases (SMT), not synthesized in their animal hosts that can regulate cell vi
Externí odkaz:
https://doaj.org/article/a81ef89711f1474fa8ac344486fdba14
Autor:
Medhanie E. Kidane, Boden H. Vanderloop, Wenxu Zhou, Crista D. Thomas, Emilio Ramos, Ujjal Singha, Minu Chaudhuri, W. David Nes
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 12, Pp 2310-2323 (2017)
Ergosterol biosynthesis pathways essential to pathogenic protozoa growth and absent from the human host offer new chokepoint targets. Here, we present characterization and cell-based interference of Acanthamoeba spp sterol 24-/28-methylases (SMTs) th
Externí odkaz:
https://doaj.org/article/c5dd241f6f744dcebd1bd6c255049167
Autor:
Anuj Tripathi, Ujjal K. Singha, Victor Paromov, Salisha Hill, Siddharth Pratap, Kristie Rose, Minu Chaudhuri
Publikováno v:
mSphere, Vol 4, Iss 5 (2019)
Externí odkaz:
https://doaj.org/article/0d79663be35f4f838f3d5219ece1a51f
Autor:
Anuj Tripathi, Ujjal K. Singha, Victor Paromov, Salisha Hill, Siddharth Pratap, Kristie Rose, Minu Chaudhuri
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT Trypanosoma brucei, the infectious agent of a deadly disease known as African trypanosomiasis, undergoes various stresses during its digenetic life cycle. We previously showed that downregulation of T. brucei mitochondrial inner membrane pro
Externí odkaz:
https://doaj.org/article/adf9685fe8934cc8ba9b3c2b6c2aed4b
Autor:
Linda S Quinones Guillen, Fidel S Gonzalez, Chauncey Darden, Muhammad Khan, Anuj Tripathi, Joseph Smith, Ayorinde Cooley, Victor Paromov, Jamaine Davis, Smita Misra, Minu Chaudhuri
Publikováno v:
bioRxiv
Trypanosoma brucei is an early divergent parasitic protozoan that causes a fatal disease, African trypanosomiasis. T. brucei possesses a unique and essential translocase of the mitochondrial inner membrane, the TbTIM17 complex. TbTim17 associates wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b3666dbec60e8225fac3c005e65269
https://europepmc.org/articles/PMC10312748/
https://europepmc.org/articles/PMC10312748/
