Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Minqing Rong"'
Publikováno v:
BioTechniques, Vol 27, Iss 4, Pp 690-694 (1999)
Externí odkaz:
https://doaj.org/article/c45cf1566f504f72833eddd31a9d05e3
Autor:
Minqing Rong, Brian Lucas, Wendy Zhong, Guifen Xu, Gary Lee, Ben Jiang, Angela Chong, Qiuping Ye, Michael DeGraffenreid, Tom Huang, Dineli Wickramasinghe, Randall W. Hungate, Wade Aaron, Michael G. Johnson, Jessica Orf, Dustin McMinn, Matthew L. Brown, Richard J. Austin, Maria M. Toteva, Jacob Kaizerman, Jay P. Powers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5206-5209
A bis-amide antagonist of Smoothened, a seven-transmembrane receptor in the Hedgehog signaling pathway, was discovered via high throughput screening. In vitro and in vivo experiments demonstrated that the bis-amide was susceptible to N-acyl transfera
Autor:
Alexander Kamb, Dineli Wickramasinghe, Minqing Rong, Astrid Ruefli-Brasse, Tim Carlson, Kim Quon, Jianxia Shi, Jessica Orf, Doreen Sakamoto
Publikováno v:
Journal of Cancer Therapy. :523-534
Methylthioadenosine phosphorylase, (MTAP) is a key enzyme in the adenine and methionine salvage pathways. MTAP is encoded on human chromosome 9p21 in close proximity to the p16INK4a and p14ARF tumor suppressor genes and is frequently co-deleted with
Autor:
Ben Jiang, Michael G. Johnson, Maria M. Toteva, Dustin McMinn, Brian Lucas, Richard J. Austin, Wendy Zhong, Qiuping Ye, Matthew L. Brown, Tom Huang, Guifen Xu, Randall W. Hungate, Dineli Wickramasinghe, Jessica Orf, Gary Lee, Minqing Rong, Songzhu An, Wade Aaron, Angela Chong, Jacob Kaizerman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4607-4610
Pyridopyridazine antagonists of the hedgehog signaling pathway are described. Designed to optimize our previously described phthalazine smoothened antagonists, a representative compound eliminates a PXR liability while retaining potency and in vitro
Autor:
Astrid Strelow, Timothy Hoey, Holger Wesche, Scott Powers, Jessica Orf, Anthony J. Slavin, Shyun Li, Minqing Rong, Ken Q. C. Nguyen, Lawrence Chinn, Yan Degenhardt, Edward H. van der Horst, Lei-Hoon See
Publikováno v:
Proceedings of the National Academy of Sciences. 102:15901-15906
Metastasis of primary tumors leads to a very poor prognosis for patients suffering from cancer. Although it is well established that not every tumor will eventually metastasize, it is less clear whether primary tumors acquire genetic alterations in a
Autor:
Sami Damak, Robert F. Margolskee, Keiko Yasumatsu, Yuzo Ninomiya, Minqing Rong, Shiying Zou, Peihua Jiang, Zaza Kokrashvili, Vijaya Varadarajan
Publikováno v:
Science. 301:850-853
The tastes of sugars (sweet) and glutamate (umami) are thought to be detected by T1r receptors expressed in taste cells. Molecular genetics and heterologous expression implicate T1r2 plus T1r3 as a sweet-responsive receptor,and T1r1 plus T1r3,as well
Autor:
Cristian A. Pérez, Liquan Huang, Minqing Rong, J. Ashot Kozak, Axel K. Preuss, Hailin Zhang, Marianna Max, Robert F. Margolskee
Publikováno v:
Nature Neuroscience. 5:1169-1176
We used differential screening of cDNAs from individual taste receptor cells to identify candidate taste transduction elements in mice. Among the differentially expressed clones, one encoded Trpm5, a member of the mammalian family of transient recept
Publikováno v:
Journal of Molecular Biology. 310:509-522
We have explored the effects of a variety of structural and sequence changes in the initiation region of the phage T7 promoter on promoter function. At promoters in which the template strand (T strand) is intact, initiation is directed a minimal dist
Autor:
Dmitry Temiakov, Russell K. Durbin, Biao He, Stephen T. Chin-Bow, Dmitry L Lyakhov, William T. McAllister, Minqing Rong, Alexander Kukarin
Publikováno v:
Journal of Biological Chemistry. 273:18802-18811
We have characterized an unusual type of termination signal for T7 RNA polymerase that requires a conserved 7-base pair sequence in the DNA (ATCTGTT in the non-template strand). Each of the nucleotides within this sequence is critical for function, a
Publikováno v:
Proceedings of the National Academy of Sciences. 95:515-519
The high specificity of T7 RNA polymerase (RNAP) for its promoter sequence is mediated, in part, by a specificity loop (residues 742–773) that projects into the DNA binding cleft (1). Previous work demonstrated a role for the amino acid residue at