A promoterless AAV6.2FF-based lung gene editing platform for the correction of surfactant protein B deficiency.

Autor: Thomas SP; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Domm JM; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., van Vloten JP; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Xu L; Regenerative Medicine Program, The Ottawa Hospital Research Institute (OHRI), Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO), and CHEO Research Institute, Ottawa, ON K1Y 4E9, Canada., Vadivel A; Regenerative Medicine Program, The Ottawa Hospital Research Institute (OHRI), Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO), and CHEO Research Institute, Ottawa, ON K1Y 4E9, Canada., Yates JGE; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Pei Y; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Ingrao J; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., van Lieshout LP; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Jackson SR; Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA., Minott JA; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Achuthan A; Regenerative Medicine Program, The Ottawa Hospital Research Institute (OHRI), Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO), and CHEO Research Institute, Ottawa, ON K1Y 4E9, Canada., Mehrani Y; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., McAusland TM; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Zhang W; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada., Karimi K; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Vaughan AE; Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA., de Jong J; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Kang MH; Department of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA., Thebaud B; Regenerative Medicine Program, The Ottawa Hospital Research Institute (OHRI), Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO), and CHEO Research Institute, Ottawa, ON K1Y 4E9, Canada., Wootton SK; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada. Electronic address: kwootton@uoguelph.ca.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2023 Dec 06; Vol. 31 (12), pp. 3457-3477. Date of Electronic Publication: 2023 Oct 07.

Dendritic Cell Vaccines Impact the Type 2 Innate Lymphoid Cell Population and Their Cytokine Generation in Mice.

Autor: Chan L; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada., Mehrani Y; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.; Department of Clinical Science, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad P.O. Box 91775-1111, Iran., Minott JA; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada., Bridle BW; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada., Karimi K; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.

Publikováno v: Vaccines [Vaccines (Basel)] 2023 Oct 03; Vol. 11 (10). Date of Electronic Publication: 2023 Oct 03.

Multiplex flow cytometry-based assay for quantifying tumor- and virus-associated antibodies induced by immunotherapies.

Autor: Minott JA; Department of Pathobiology, University of Guelph, Guelph, ON, Canada., van Vloten JP; Department of Pathobiology, University of Guelph, Guelph, ON, Canada., Yates JGE; Department of Pathobiology, University of Guelph, Guelph, ON, Canada., Chan L; Department of Pathobiology, University of Guelph, Guelph, ON, Canada., Wood GA; Department of Pathobiology, University of Guelph, Guelph, ON, Canada., Viloria-Petit AM; Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada., Karimi K; Department of Pathobiology, University of Guelph, Guelph, ON, Canada., Petrik JJ; Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada., Wootton SK; Department of Pathobiology, University of Guelph, Guelph, ON, Canada., Bridle BW; Department of Pathobiology, University of Guelph, Guelph, ON, Canada.; ImmunoCeutica Inc., Cambridge, ON, Canada.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Nov 16; Vol. 13, pp. 1038340. Date of Electronic Publication: 2022 Nov 16 (Print Publication: 2022).

Adeno-associated virus mediated expression of monoclonal antibody MR191 protects mice against Marburg virus and provides long-term expression in sheep.

Autor: Rghei AD; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., van Lieshout LP; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., Cao W; Special Pathogens Program, Public Health Agency of Canada, Winnipeg, MB, R3E 3R2, Canada., He S; Special Pathogens Program, Public Health Agency of Canada, Winnipeg, MB, R3E 3R2, Canada., Tierney K; Special Pathogens Program, Public Health Agency of Canada, Winnipeg, MB, R3E 3R2, Canada., Lopes JA; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., Zielinska N; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., Baracuhy EM; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., Campbell ESB; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., Minott JA; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., Guilleman MM; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., Hasson PC; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., Thompson B; Avamab Pharma Inc, Calgary, AB, T2T 2P9, Canada., Karimi K; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., Bridle BW; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., Susta L; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., Qiu X; Special Pathogens Program, Public Health Agency of Canada, Winnipeg, MB, R3E 3R2, Canada., Banadyga L; Special Pathogens Program, Public Health Agency of Canada, Winnipeg, MB, R3E 3R2, Canada., Wootton SK; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada. kwootton@uoguelph.ca.

Publikováno v: Gene therapy [Gene Ther] 2022 Sep 01. Date of Electronic Publication: 2022 Sep 01.

AAV-Vectored Expression of the Vascular Normalizing Agents 3TSR and Fc3TSR, and the Anti-Angiogenic Bevacizumab Extends Survival in a Murine Model of End-Stage Epithelial Ovarian Carcinoma.

Autor: Stegelmeier AA; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Santry LA; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Guilleman MM; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Matuszewska K; Department of Biomedical Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada., Minott JA; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Yates JGE; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Stevens BAY; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Thomas SP; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Vanderkamp S; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Hanada K; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Pei Y; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Rghei AD; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., van Vloten JP; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Pereira M; Department of Biomedical Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada., Thompson B; Avamab Pharma Inc., Calgary, AB T3E 6L1, Canada., Major PP; Juravinski Cancer Centre, 699 Concession Street, Hamilton, ON L8V 5C2, Canada., Petrik JJ; Department of Biomedical Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada., Bridle BW; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Wootton SK; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.

Publikováno v: Biomedicines [Biomedicines] 2022 Feb 02; Vol. 10 (2). Date of Electronic Publication: 2022 Feb 02.