Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Minoti Bhakta"'
Autor:
Ralitsa Petrova, Abhijeet R. Patil, Vivian Trinh, Kathryn E. McElroy, Minoti Bhakta, Jason Tien, David S. Wilson, Liling Warren, Jennifer R. Stratton
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare and devastating childhood-onset lysosomal storage disease caused by complete loss of function of the lysosomal hydrolase α-N-acetylglucosaminidase. The lack of functional enzyme in MPS II
Externí odkaz:
https://doaj.org/article/efa2650a037a46579e6a5721ffce4f53
Autor:
Samadrita Bhattacharyya, Rahul K. Kollipara, Gabriela Orquera-Tornakian, Sean Goetsch, Minzhe Zhang, Cameron Perry, Boxun Li, John M. Shelton, Minoti Bhakta, Jialei Duan, Yang Xie, Guanghua Xiao, Bret M. Evers, Gary C. Hon, Ralf Kittler, Nikhil V. Munshi
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Comprehensive cis-regulatory landscapes are essential for accurate enhancer prediction and disease variant mapping. Although cis-regulatory element (CRE) resources exist for most tissues and organs, many rare — yet functionally important — cell t
Externí odkaz:
https://doaj.org/article/46dde78eea664fca9e8ce2e867c261c0
Publikováno v:
Cell Reports, Vol 27, Iss 12, Pp 3486-3499.e6 (2019)
Summary: Ectopic expression of transcription factors (TFs) can reprogram cell state. However, because of the large combinatorial space of possible TF cocktails, it remains difficult to identify TFs that reprogram specific cell types. Here, we develop
Externí odkaz:
https://doaj.org/article/2805e13f0d1e46ccab417572d87d423c
Autor:
Antonio Fernandez-Perez, Adwait Amod Sathe, Minoti Bhakta, Kayla Leggett, Chao Xing, Nikhil Vilas Munshi
Publikováno v:
Cell Reports, Vol 27, Iss 8, Pp 2354-2369.e7 (2019)
Summary: Gata4, Hand2, Mef2c, and Tbx5 (GHMT) can reprogram transduced fibroblasts into induced pacemaker-like myocytes (iPMs), but the underlying mechanisms remain obscure. Here, we explore the role of Hand2 in iPM formation by using a combination o
Externí odkaz:
https://doaj.org/article/154c813dc5234dd7908ecb9758ce36c6
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214677 (2019)
Recent studies have highlighted the extraordinary cell type diversity that exists within mammalian organs, yet the molecular drivers of such heterogeneity remain elusive. To address this issue, much attention has been focused on profiling the transcr
Externí odkaz:
https://doaj.org/article/75ffe8c2e6094e80b85abdb2fd326737
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174517 (2017)
The cardiac conduction system (CCS) is composed of specialized cardiomyocytes that initiate and maintain cardiac rhythm. Any perturbation to the normal sequence of electrical events within the heart can result in cardiac arrhythmias. To understand ho
Externí odkaz:
https://doaj.org/article/7c6ef6a1b61e4aff97ce2136202bbc19
Autor:
Samadrita Bhattacharyya, Jialei Duan, Ryan J. Vela, Minoti Bhakta, Pietro Bajona, Pradeep P.A. Mammen, Gary C. Hon, Nikhil V. Munshi
Publikováno v:
Circulation. 146:878-881
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61add26e44250bb0593e7339da7e5036
https://doi.org/10.1161/circulationaha.122.059659
https://doi.org/10.1161/circulationaha.122.059659
Autor:
Samadrita Bhattacharyya, Rahul K. Kollipara, Gabriela Orquera-Tornakian, Sean Goetsch, Minzhe Zhang, Cameron Perry, Boxun Li, John M. Shelton, Minoti Bhakta, Jialei Duan, Yang Xie, Guanghua Xiao, Bret M. Evers, Gary C. Hon, Ralf Kittler, Nikhil V. Munshi
Publikováno v:
The Journal of clinical investigation.
Comprehensive cis-regulatory landscapes are essential for accurate enhancer prediction and disease variant mapping. Although cis-regulatory element (CRE) resources exist for most tissues and organs, many rare - yet functionally important - cell types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e269edf38ffe355921715ce7833bd9
https://pubmed.ncbi.nlm.nih.gov/36454649
https://pubmed.ncbi.nlm.nih.gov/36454649
Autor:
Kimberly D. Mackenzie, Jennifer Stratton, Minoti Bhakta, David Wilson, Tetsuya Taura, Trang Vuong
Publikováno v:
Cephalalgia
Background The clinical efficacy of migraine therapeutic agents directed towards the calcitonin-gene related peptide (CGRP) pathway has confirmed the key role of this axis in migraine pathogenesis. Three antibodies against CGRP – fremanezumab, galc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e330aea5e998af41ffb7ecfe33ee20
https://doi.org/10.1177/0333102420983282
https://doi.org/10.1177/0333102420983282
Publikováno v:
Journal of Clinical Investigation. 131
The cardiac conduction system (CCS) ensures regular contractile function, and injury to any of its components can cause cardiac dysrhythmia. Although all cardiomyocytes (CMs) originate from common progenitors, the CCS is composed of biologically dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57ef4b9e874678427067797d750eb182
https://doi.org/10.1172/jci138637
https://doi.org/10.1172/jci138637