Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Minoru Sasano"'
Autor:
Iwao Seki, Miwa Takai-Imamura, Tomomi Kohara-Tanaka, Satoshi Shirae, Minoru Sasano, Hiroaki Matsuno, Hiroyuki Aono
Publikováno v:
Mediators of Inflammation, Vol 2019 (2019)
In the present study, we investigated the effects and mechanisms of action of a combined treatment with etanercept, a soluble tumor necrosis factor receptor (p75) Fc fusion protein, and tacrolimus, a calcineurin inhibitor on the progression of arthri
Externí odkaz:
https://doaj.org/article/9a36ee8a65d843469aff6adaeb06fa00
Autor:
Fumio Tsuji, Masaaki Murai, Kenji Oki, Hiroyuki Inoue, Minoru Sasano, Hiroyuki Tanaka, Naoki Inagaki, Hiroyuki Aono
Publikováno v:
Journal of Pharmacological Sciences, Vol 112, Iss 4, Pp 487-490 (2010)
We recently demonstrated that SA13353, a transient receptor potential vanilloid 1 (TRPV1) agonist, reduced the severity of the symptoms of kidney injury, arthritis, and encephalomyelitis in disease models. Here, we investigated the effects of orally
Externí odkaz:
https://doaj.org/article/d3fb78666d4b44a2890e2c1e4ae99f8a
Autor:
Shouhei Nagaoka, Kou Katayama, Akira Sagawa, Masao Sato, Minoru Sasano, Shigeru Ohno, Tsuyoshi Kasama, Hiroshi Kataoka, Akira Furusaki, Yoshiharu Amasaki, Yujiro Kon, Masahiro Okamoto
Publikováno v:
International Journal of Rheumatic Diseases. 23:1328-1336
Aims We compared the incidence of adverse events between single and divided-dose regimens of methotrexate (MTX) by using a multicenter randomized controlled trial. Methods Eighty-nine patients with insufficient control on MTX 8 mg/wk were randomly as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2580b631ab2281a9334cab8782046a
https://doi.org/10.1111/1756-185x.13931
https://doi.org/10.1111/1756-185x.13931
Publikováno v:
Inflammation and Regeneration. 31:95-101
The transient receptor potential vanilloid-1 (TRPV1) cation channel is a receptor that is activated by heat, acidosis and a variety of chemicals, including capsaicin. With these properties, TRPV1 has emerged as a polymodal nocisensor of nociceptive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26a1a507e96fa556fa3a5f0bb9687965
https://doi.org/10.2492/inflammregen.31.95
https://doi.org/10.2492/inflammregen.31.95
Autor:
Yaeko Tsukahara-Ohsumi, Masashi Niwa, Minoru Sasano, Hiroyuki Aono, Fumio Tsuji, Naoki Inagaki, Mikiko Nakamura, Keiko Mizutani
Publikováno v:
European Journal of Pharmacology. 647:62-67
SA14867 ((+)-3-Acetyl-6-chloro-2-[2-(3-(N-(2-ethoxyethyl)-N-isopropylamino)propoxy)-5-methoxyphenyl]benzothiazoline O,O'-diacetyl-L-tartrate), a selective kappa-opioid receptor agonist, was synthesized and its antinociceptive and antipruritic effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258674bc78b35b92e52234650f62dcfe
https://doi.org/10.1016/j.ejphar.2010.08.012
https://doi.org/10.1016/j.ejphar.2010.08.012
Publikováno v:
Inflammation Research. 58:571-584
To identify the molecular mechanisms of bucillamine activity, global gene expression analysis and pathway analysis were conducted using IL-1 beta-stimulated human fibroblast-like synovial cells (FLS).Normal human FLS were treated with IL-1 beta in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469ab1e50957621790ce32b039fede24
https://doi.org/10.1007/s00011-009-0021-y
https://doi.org/10.1007/s00011-009-0021-y
Autor:
Minoru Sasano, Fumio Tsuji, Hiroyuki Aono, Yoshiko Mukai, Masahiro Okamoto, Noriko Odani-Kawabata
Publikováno v:
Inflammation and Regeneration. 27:516-521
Purpose: To expect disease-modified anti-rheumatic drugs (DMARDs) combination therapy on rheumatoid arthritis (RA), combination effect of bucillamine (Buc) and methotrexate (MTX) on type II collagen-induced arthritis model (CIA) was investigated. IgM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77db43ecd44a6b59afb367f35c04b753
https://doi.org/10.2492/inflammregen.27.516
https://doi.org/10.2492/inflammregen.27.516
Autor:
Fumio Tsuji, Minoru Sasano, Hiroshi Suhara, Masato Horiuchi, Kenji Oki, Takashi Yamanouchi, Shiro Mita, Akihiko Okahara
Publikováno v:
Cytokine. 17:294-300
We investigated the effects of marimastat, an inhibitor of TNF-alpha converting enzyme and matrix metalloproteinases, and anti-TNF-alpha antibodies on a murine model for sepsis, and on arthritis in human TNF-alpha transgenic mice. Marimastat (25-200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4affcf02e19d5f8d53a052944391d93
https://doi.org/10.1006/cyto.2002.1015
https://doi.org/10.1006/cyto.2002.1015
Publikováno v:
International immunopharmacology. 14(1)
The improvement of rheumatoid factor titers in patients with rheumatoid arthritis is one of the significant clinical effects of bucillamine (Buc). In this study, we investigated the effects of SA981, an active metabolite of Buc, and methotrexate (MTX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceb34ebcb32613bbede595064f7c81a
https://pubmed.ncbi.nlm.nih.gov/22735757
https://pubmed.ncbi.nlm.nih.gov/22735757
Autor:
Yaeko Tsukahara-Ohsumi, Masashi Niwa, Minoru Sasano, Hiroyuki Aono, Taeko Hata, Minoru Narita, Fumio Tsuji, Tsutomu Suzuki
Publikováno v:
European journal of pharmacology. 671(1-3)
We examined the analgesic effect of the selective kappa opioid receptor agonist SA14867 and the balance of its antinociceptive and sedative effects. The ED 50 values of SA14867 after oral administration for acetic acid-induced writhing, first and sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb33bec04a83d7f139fc502617477ab
https://pubmed.ncbi.nlm.nih.gov/21970808
https://pubmed.ncbi.nlm.nih.gov/21970808