Výsledky vyhledávání - "Minoru Ozeki"

Construction of Acyclic All-Carbon Quaternary Stereocenter Based on Asymmetric Michael Addition of Chiral Amine

Autor: Minoru Ozeki, Aya Niki, Naoto Kojima, Kenji Arimitsu, Hiroki Iwasaki, Manabu Node, Shinzo Hosoi, Akiko Kuse, Takashi Shigeta, Shiho Nakagawa, Shui Aoki, Masayuki Yamashita, Ikuo Kawasaki, Tetsuya Kajimoto

Publikováno v: Chemical and Pharmaceutical Bulletin. 69:926-930

Acyclic asymmetric quaternary stereocenters, which are composed of four carbon-carbon bonds, were finely constructed by utilizing a face-selective alkylation of enolate intermediates derived from an asymmetric Michael addition reaction of a chiral li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17dc3278dcd8ec6466cdf6550b17ab17
https://doi.org/10.1248/cpb.c21-00436

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Preparation and Evaluation of Poly-γ-glutamic Acid Hydrogel Mixtures with Amlodipine Besylate: Effect on Ease of Swallowing and Taste Masking

Autor: Ikuo Kawasaki, Haruka Nishikawa, Tamami Haraguchi, Minoru Ozeki, Honami Kojima, Takahiro Uchida, Miyako Yoshida, Saeri Ikegami

Publikováno v: Chemical and Pharmaceutical Bulletin. 67:1284-1292

The purpose of the study was to prepare a poly-γ-glutamic acid hydrogel (PGA gel), to evaluate physicochemical properties, its ease of swallowing using texture profile analysis (TPA) and its taste-masking effects on amlodipine besylate (AML) using t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b7e761a2d0bd530f1d0a75c5cc5bd5
https://doi.org/10.1248/cpb.c19-00548

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Bitterness-Masking Effects of Different Beverages on Zopiclone and Eszopiclone Tablets

Autor: Kazuhiro Yamamoto, Midori Hirai, Honami Kojima, Atsushi Uda, Tamami Haraguchi, Miyako Yoshida, Ikuo Kawasaki, Minoru Ozeki, Takahiro Uchida, Ikuko Yano

Publikováno v: Chemical and Pharmaceutical Bulletin. 67:404-409

The purpose of the study was to evaluate the ability of different beverages to mask the bitterness of zopiclone and eszopiclone in tablet formulations using the artificial taste sensor and human gustatory sensation testing. The beverages tested for b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ceef4dcad2e3f873e5e3f48d74e2dbf
https://doi.org/10.1248/cpb.c18-00502

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Antimicrobial Activities of LL-37 Fragment Mutant-Poly (Lactic-Co-Glycolic) Acid Conjugate against Staphylococcus aureus, Escherichia coli, and Candida albicans

Autor: Rie Kakehashi, Takeshi Mori, Daisuke Ishibashi, Honami Kojima, Takahiro Uchida, Toshihiro Nagao, Ikuo Kawasaki, Taku Yamashita, Minoru Ozeki, Miyako Yoshida, Rio Uno, Mai Hazekawa, Jun-ichi Nishikawa, Yoshiro Hatanaka

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 10
International Journal of Molecular Sciences, Vol 22, Iss 5097, p 5097 (2021)

Various peptides and their derivatives have been reported to exhibit antimicrobial activities. Although these activities have been examined against microorganisms, novel methods have recently emerged for conjugation of the biomaterials to improve the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a068183aed98d6f78e715429499c0436

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Antimicrobial Activities of LL-37 Fragment Mutant-Poly (Lactic-Co-Glycolic) Acid Conjugate against

Autor: Takeshi, Mori, Miyako, Yoshida, Mai, Hazekawa, Daisuke, Ishibashi, Yoshiro, Hatanaka, Toshihiro, Nagao, Rie, Kakehashi, Honami, Kojima, Rio, Uno, Minoru, Ozeki, Ikuo, Kawasaki, Taku, Yamashita, Junichi, Nishikawa, Takahiro, Uchida

Publikováno v: International Journal of Molecular Sciences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06e9db11cd73d544562702e8e051d56a
https://pubmed.ncbi.nlm.nih.gov/34065861

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A Facile and Convenient Synthesis of Trisubstituted (E)-α,β-Unsaturated Esters by Tandem Acetylation-E1cB Reaction

Autor: Minoru Ozeki, Shinzo Hosoi, Naoto Kojima, Takashi Shigeta, Akihiro Nakamura, Hiroki Iwasaki, Ikuo Kawasaki, Aya Niki, Ayano Horie, Hideki Mizutani, Masayuki Yamashita, Tetsuya Kajimoto, Kenji Arimitsu, Ayumi Hachino, Natsuko Kobayashi

Publikováno v: Chemical and Pharmaceutical Bulletin. 67:71-74

A facile and convenient synthesis of trisubstituted (E)-α,β-unsaturated esters was developed by improving our previously established method. The new method circumvented the separation of the intermediates, which have an activating group of the hydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2d505c5707c068c53f4ec56fac6858b
https://doi.org/10.1248/cpb.c18-00666

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Preparation and Evaluation of Poly-γ-Glutamic Acid Hydrogel Mixtures with Basic Drugs or Acidic Drugs: Effect on Ease of Swallowing and Taste Masking

Autor: Miyako Yoshida, Shiho Nakamura, Tamami Haraguchi, Takahiro Uchida, Minoru Ozeki, Ikuo Kawasaki, Haruka Nishikawa, Honami Kojima, Saeri Ikegami

Publikováno v: Pharmacology & Pharmacy. 10:427-444

The purpose of this study was to prepare a poly-γ-glutamic acid hydrogel (PGA gel), to examine its ease of swallowing using texture profile analysis (TPA) and to evaluate its taste-masking effects on basic or acidic drugs using the artificial taste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6860a3828a4ee9be04660a273b7d637
https://doi.org/10.4236/pp.2019.1010035

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Novel and practical asymmetric synthesis of β 2,3 -amino esters using asymmetric Michael addition of chiral amine

Autor: Shinzo Hosoi, Toshiki Takano, Narumi Yasuda, Minoru Ozeki, Manabu Node, Honoka Egawa, Tetsuya Kajimoto, Masayuki Yamashita, Hideki Mizutani, Hiroki Iwasaki, Kenji Arimitsu, Naoto Kojima

Publikováno v: Tetrahedron. 73:2014-2021

A practical method for the synthesis of chiral β2,3-amino esters having various substituents was developed, which is characterized by an asymmetric Michael addition reaction of a chiral lithium amide with trisubstituted (E)-α,β-unsaturated esters.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8a96b70810cd6bc131c2a6c96429d9c
https://doi.org/10.1016/j.tet.2017.02.037

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