Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Minoru, Seto"'
Autor:
Asako Hitomi, Steven K. Feske, Koh Kawasaki, Yasuo Sasaki, Galen V. Henderson, Farzaneh A. Sorond, James K. Liao, Toshio Asano, Minoru Seto
Publikováno v:
Brain Research. 1257:89-93
Background Rho-kinase (ROCK) is a downstream effector of Rho GTPase that is known to regulate various pathological processes important to the development of ischemic stroke, such as thrombus formation, inflammation, and vasospasm. Inhibition of ROCK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6727c25c761db6337ff71e255e23691b
https://doi.org/10.1016/j.brainres.2008.12.045
https://doi.org/10.1016/j.brainres.2008.12.045
Autor:
Kazuo Yano, Koh Kawasaki, Yuji Ohtsuka, Shunsuke Tawara, Hiroshi Kuriyama, Yuki Yoshino, Toshio Asano, Kunie Sasaki, Minoru Seto, Shin'ichi Satoh, Ichiro Ikegaki
Publikováno v:
Journal of Molecular Neuroscience. 39:59-68
Whether Rho-kinase activity is really associated with the pathogenesis of cerebral infarction remains unclear. To consider this question, we investigated correspondences between severity of neurological deficit, infarct size, amount of various marker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4386b16bc7ffaf62d6504dbc082c9ff
https://doi.org/10.1007/s12031-009-9175-x
https://doi.org/10.1007/s12031-009-9175-x
Autor:
Mamunur Rashid, Minoru Seto, Hiroaki Shimokawa, Kazuo Yano, Yoshihiro Fukumoto, Shunsuke Tawara
Publikováno v:
Circulation Journal. 73:361-370
Background The pleiotropic effects of HMG-CoA reductase inhibitors (statins) are thought to be mediated through inhibition of small GTP-binding proteins; however, it remains to be examined whether clinical concentrations/doses of statins actually exe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af83fb91d36ab7b9d9b982dc666d1a0b
https://doi.org/10.1253/circj.cj-08-0817
https://doi.org/10.1253/circj.cj-08-0817
Autor:
Yoshio Suzuki, Minoru Seto, Shin'ichi Satoh, Hirotoshi Sugiyama, Kintomo Takakura, Masato Shibuya
Publikováno v:
Neurologia medico-chirurgica. 48:241-248
Sub-analysis of the fasudil post-marketing surveillance study compared the safety and efficacy of fasudil plus ozagrel to fasudil only. A total of 3690 patients received fasudil and 1138 received fasudil plus ozagrel between 1995 and 2000. The occurr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a4eb79d95da2cb3f423a63ff138a1b
https://doi.org/10.2176/nmc.48.241
https://doi.org/10.2176/nmc.48.241
Publikováno v:
Journal of Cardiovascular Pharmacology. 50:17-24
The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various important cellular functions such as cell shape, motility, secretion, proliferation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2cc29ebe554ad93d2f70327ab9ca41
https://doi.org/10.1097/fjc.0b013e318070d1bd
https://doi.org/10.1097/fjc.0b013e318070d1bd
Autor:
Yasuo Mori, Yuji Kiuchi, Shunichi Shimizu, Minoru Wakamori, Masakazu Ishii, Katsuhiko Sakurada, Takaharu Okada, Masami Takahashi, Takashi Yoshida, Minoru Seto
Publikováno v:
The Journal of Physiology. 570:219-235
Mammalian homologues of Drosophila transient receptor potential (TRP) proteins are responsible for receptor-activated Ca2+ influx in vertebrate cells. We previously reported the involvement of intracellular Ca2+ in the receptor-mediated activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70eb11e54e8a459199903c1d9f49dc48
https://doi.org/10.1113/jphysiol.2005.097998
https://doi.org/10.1113/jphysiol.2005.097998
Publikováno v:
Journal of the Neurological Sciences. 238:31-39
Background: A multicenter, double-blind, placebo-controlled study was conducted to assess the efficacy and safety of fasudil, a Rhokinase inhibitor (RKI), in the treatment of acute ischemic stroke. Methods: A total of 160 patients, who were able to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7721b8080d34388a49ea53606e0f22f
https://doi.org/10.1016/j.jns.2005.06.003
https://doi.org/10.1016/j.jns.2005.06.003
Autor:
Hideaki Karaki, Masatoshi Hori, Yoon-Sun Kim, Hiroshi Ozaki, Makoto Egawa, Minoru Seto, Hideharu Kanzaki, Hiroshi Nakazawa, Katsuhiko Yasuda
Publikováno v:
British Journal of Pharmacology. 140:1303-1312
Activation of protein kinase C (PKC) by phorbol 12,13-dibutylate (PDBu, 1 μM) induced sustained contractions with no increase in [Ca2+]i in nonpregnant and pregnant human myometria. The contractile effects of PDBu in pregnant myometrium were much gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fea3993e9fc0ff6330e3b534a3b1ee6e
https://doi.org/10.1038/sj.bjp.0705552
https://doi.org/10.1038/sj.bjp.0705552
Autor:
Quang-Dé Nguyen, Sandrine Faivre, Christian Gespach, Takeshi Endo, Christine Rivat, Erik Bruyneel, Shahin Emami, Minoru Seto, Marc Mareel
Publikováno v:
The FASEB Journal. 16:565-576
Thrombin and proteinase-activated receptors (PAR) specifically regulate several functions that markedly enhance the transformation phenotype such as inflammation, cell proliferation, tumor growth, and metastasis. We recently reported that thrombin in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc72e1affed5dd178ddd92735fee960
https://doi.org/10.1096/fj.01-0525com
https://doi.org/10.1096/fj.01-0525com
Autor:
Ling Pan, Minoru Seto, Hiroshi Watanabe, Quang-Kim Tran, Kazuhiko Takeuchi, Kyoichi Ohashi, Hong-Yen Le
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 21:509-515
Abstract —Monocytes/macrophages are present in all stages of atherosclerosis. Although many of their activities depend to various extents on changes in intracellular Ca 2+ concentration ([Ca 2+ ] i ), mechanisms regulating [Ca 2+ ] i in these cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ec8b853952f5c9b2a570a4ccacb495
https://doi.org/10.1161/01.atv.21.4.509
https://doi.org/10.1161/01.atv.21.4.509