Výsledky vyhledávání - "Minoo Ahdieh"

Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-γ

Autor: Tim Vandenbos, Adel Youakim, Minoo Ahdieh

Publikováno v: American Journal of Physiology-Cell Physiology. 281:C2029-C2038

To understand the effects of cytokines on epithelial cells in asthma, we have investigated the effects of interleukin (IL)-4, IL-13, and interferon (IFN)-γ on barrier function and wound healing in Calu-3 human lung epithelial cells. IL-4 and IL-13 t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181acc157a8575f24685489765b76481
https://doi.org/10.1152/ajpcell.2001.281.6.c2029

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Interferon-γ decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin

Autor: Adel Youakim, Minoo Ahdieh

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 276:G1279-G1288

The effects of interferon-gamma (IFN-gamma) on tight junctions in T84 human intestinal epithelial cells were investigated. Treatment of T84 cells with IFN-gamma caused a dose- and time-dependent increase in monolayer permeability as assessed by trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61e7f99f1791d87f1e9eb373f8ba03b
https://doi.org/10.1152/ajpgi.1999.276.5.g1279

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Interleukin-15 up-regulates interleukin-2 receptor α chain but down-regulates its own high-affinity binding sites on human T and B cells

Autor: Linda Park, Richard J. Armitage, Minoo Ahdieh, Satoru Kumaki, David Cosman

Publikováno v: European Journal of Immunology. 26:1235-1239

The cytokines interleukin (IL)-2 and IL-15 share many biological activities as a consequence of their utilization of the beta and gamma chains of the IL-2 receptor. However, each cytokine binds to a specific receptor alpha chain; IL-2 with low affini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9937580c207fff13c5393617c48a12
https://doi.org/10.1002/eji.1830260608

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Functional Characterization of the Human Interleukin-15 Receptor αChain and Close Linkage of IL15RA and IL2RA Genes

Autor: Jeanette S. Bertles, Linda S. Park, Aaron Loomis, Dirk M. Anderson, Satoru Kumaki, Virginia Valentine, Judith G. Giri, Mark E. Tometsko, Neal G. Copeland, Nancy A. Jenkins, Stephan W. Morris, Debra J. Gilbert, Minoo Ahdieh, David N. Shapiro, David Cosman

Publikováno v: Journal of Biological Chemistry. 270:29862-29869

Interleukins-2 and -15 (IL-2 and IL-15) are cytokines with overlapping but distinct biological effects. Their receptors share two subunits (the IL-2R beta and -gamma chains) that are essential for signal transduction. The IL-2 receptor requires an ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb2758260037517ed4ba344359d4aea
https://doi.org/10.1074/jbc.270.50.29862

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Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor

Autor: Kenneth H. Grabstein, Dirk M. Anderson, June Eisenmann, Judith G. Giri, Matthew J. Lindemann, Raymond J. Paxton, William E. Carson, Minoo Ahdieh, Michael L. Linett, Michael A. Caligiuri

Publikováno v: The Journal of Experimental Medicine

Interleukin 15 (IL-15) is a novel cytokine that has recently been cloned and expressed. Whereas it has no sequence homology with IL-2, IL-15 interacts with components of the IL-2 receptor (IL-2R). In the present study we performed a functional analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01faf40182401c003d086ba55e2729c
https://doi.org/10.1084/jem.180.4.1395

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Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

Autor: Lisabeth Johnson, June R. Eisenman, Courtney Beers, Subhashini Srinivasan, Judith G. Giri, Minoo Ahdieh, Dirk M. Anderson, Jane S. Richardson, Kurt D. Shanebeck, Kenneth H. Grabstein, James D. Watson, Mark R. Alderson, Victor Fung, Michael A. Schoenborn, Charles Rauch

Publikováno v: Science. 264:965-968

A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4f6dee08e65f834b572bc0ddd5d18c
https://doi.org/10.1126/science.8178155

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Interleukin 15 and Its Receptor

Autor: David Cosman, Satoru Kumaki, Minoo Ahdieh, June Eisenman, Kenneth H. Grabstein, Ray Paxton, Robert DuBose, Della Friend, Linda S. Park, Dirk Anderson, Judith G. Giri

Publikováno v: Novartis Foundation Symposia ISBN: 9780470514849
Ciba Foundation Symposium 195 - T Cell Subsets in Infectious and Autoimmune Diseases

Interleukin 15 (IL-15) is a member of the four-helix bundle cytokine family that shares many in vitro biological activities with IL-2. Previous work demonstrated that IL-15 utilizes the beta and gamma chains of the IL-2 receptor (IL-2R), and that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87570c755c3cd9c52920ad7536826403
https://doi.org/10.1002/9780470514849.ch15

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Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity

Autor: Linda S. Park, Mary K. Kennedy, Tiep Le, Courtney Beers, Timothy P. Bonnert, Kenneth Brasel, Minoo Ahdieh, June R. Eisenman, Raymond J. Paxton

Publikováno v: Cytokine. 20(3)

Interleukin (IL-) 2 and IL-15 share the IL-2 receptor betagamma c subunits (IL-2Rbetagamma c) but have specific, unique alpha receptor subunits. We studied species specificity of human (hu), simian (si), and mouse (mu) IL-15 and found that hu and si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66925e64b304d250b8b1b6e22564ca99
https://pubmed.ncbi.nlm.nih.gov/12453470

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