Causes and consequences of hyperexcitation in central clock neurons.

Autor: Casey O Diekman, Mino D C Belle, Robert P Irwin, Charles N Allen, Hugh D Piggins, Daniel B Forger

Publikováno v: PLoS Computational Biology, Vol 9, Iss 8, p e1003196 (2013)

Hyperexcited states, including depolarization block and depolarized low amplitude membrane oscillations (DLAMOs), have been observed in neurons of the suprachiasmatic nuclei (SCN), the site of the central mammalian circadian (~24-hour) clock. The cau

Externí odkaz: https://doaj.org/article/04e00aa9d7f74cf88acc5183d8a6aa55

PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia

Autor: Tansi Khodai, Nicolas Nunn, Amy A. Worth, Claire H. Feetham, Mino D. C. Belle, Hugh D. Piggins, Simon M. Luckman

Publikováno v: Frontiers in Endocrinology, Vol 9 (2018)

Background: Glucose-sensing neurons are located in several parts of the brain, but are concentrated in the ventromedial nucleus of the hypothalamus (VMH). The importance of these VMH neurons in glucose homeostasis is well-established, however, little

Externí odkaz: https://doaj.org/article/0b05d9e828ad4c47a2db06338b39acc6

Author response: Daily electrical activity in the master circadian clock of a diurnal mammal

Autor: Robert J. Lucas, Timothy M. Brown, Beatriz Bano-Otalora, Casey O. Diekman, Matthew J. Moye, Mino D. C. Belle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d8a18da46567520b9b72ba7122f2969
https://doi.org/10.7554/elife.68179.sa2

Bright daytime light enhances circadian amplitude in a diurnal mammal

Autor: Timothy M. Brown, Court Harding, David A. Bechtold, Robert J. Lucas, Annette E. Allen, Franck P. Martial, Beatriz Bano-Otalora, Mino D. C. Belle

Publikováno v: Bano-Otalora, B, Martial, F, Harding, C, Bechtold, D A, Allen, A E, Brown, T M, Belle, M D C & Lucas, R J 2021, ' Bright daytime light enhances circadian amplitude in a diurnal mammal ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 22, e2100094118 . https://doi.org/10.1073/pnas.2100094118
Proceedings of the National Academy of Sciences of the United States of America

Significance Light is an important regulator of endogenous circadian clocks. Regular light–dark cycles set circadian phase to ensure synchrony with external time, while irregular or inappropriate light exposure can disrupt circadian rhythms. We ask

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e6bb3cea5cbc85c7a681713f74cb82
https://www.pnas.org/content/pnas/118/22/e2100094118.full.pdf

Perforated Multi-Electrode Array Recording in Hypothalamic Brain Slices

Autor: Mino D. C. Belle, Beatriz Bano-Otalora, Hugh D. Piggins

Publikováno v: Circadian Clocks ISBN: 9781071603802

The ability to record ensemble action potential (AP) discharge frequencies from large populations of neurons over extended periods of time in vitro offers clear advantages in neuroscience and circadian biology research. Here, we provide an overview o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8bc49c3a84935eac78f8acbc289e70a
https://doi.org/10.1007/978-1-0716-0381-9_20