Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Minnal, Gupta"'
Autor:
Oliver Y. Tang, Lifeng Tian, Todd Yoder, Rong Xu, Irina Kulikovskaya, Minnal Gupta, Jan Joseph Melenhorst, Simon F. Lacey, Donald M. O’Rourke, Zev A. Binder
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The epidermal growth factor receptor variant III (EGFRvIII) has been investigated as a therapeutic target for chimeric antigen receptor (CAR) T cell therapy in glioblastoma. Earlier research demonstrated that phenotypic and genotypic characteristics
Externí odkaz:
https://doaj.org/article/1ad163a08eb94e1897776463e363af54
Autor:
Alfred L. Garfall, Adam D. Cohen, Sandra P. Susanibar-Adaniya, Wei-Ting Hwang, Dan T. Vogl, Adam J. Waxman, Simon F. Lacey, Vanessa E. Gonzalez, Joseph A. Fraietta, Minnal Gupta, Irina Kulikovskaya, Lifeng Tian, Fang Chen, Natalka Koterba, Robert L. Bartoszek, Margaret Patchin, Rong Xu, Gabriela Plesa, Don L. Siegel, Andrea Brennan, Anne Marie Nelson, Regina Ferthio, Angela Cosey, Kim-Marie Shea, Rachel Leskowitz, Megan Four, Wesley V. Wilson, Fei Miao, Eric Lancaster, Beatriz M. Carreno, Gerald P. Linette, Elizabeth O. Hexner, Regina M. Young, Dexiu Bu, Keith G. Mansfield, Jennifer L. Brogdon, Carl H. June, Michael C. Milone, Edward A. Stadtmauer
Publikováno v:
Blood Cancer Discovery. 4:118-133
We conducted a phase I clinical trial of anti-BCMA chimeric antigen receptor T cells (CART-BCMA) with or without anti-CD19 CAR T cells (huCART19) in multiple myeloma (MM) patients responding to third- or later-line therapy (phase A, N = 10) or high-r
Autor:
M. Kazim Panjwani, Matthew J. Atherton, Martha A. MaloneyHuss, Kumudhini P. Haran, Ailian Xiong, Minnal Gupta, Irina Kulikovsaya, Simon F. Lacey, Nicola J. Mason
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Multiple rodent and primate preclinical studies have advanced CAR T cells into the clinic. However, no single model accurately reflects the challenges of effective CAR T therapy in human cancer patients. To evaluate the effectiveness of next-generati
Externí odkaz:
https://doaj.org/article/d7afee87aa414d559adb4c116f51da3a
Autor:
Edward A. Stadtmauer, Michael C. Milone, Carl H. June, Jennifer L. Brogdon, Keith G. Mansfield, Dexiu Bu, Regina M. Young, Elizabeth O. Hexner, Gerald P. Linette, Beatriz M. Carreno, Eric Lancaster, Fei Miao, Wesley V. Wilson, Megan Four, Rachel Leskowitz, Kim-Marie Shea, Angela Cosey, Regina Ferthio, Anne Marie Nelson, Andrea Brennan, Don L. Siegel, Gabriela Plesa, Rong Xu, Margaret Patchin, Robert L. Bartoszek, Natalka Koterba, Fang Chen, Lifeng Tian, Irina Kulikovskaya, Minnal Gupta, Joseph A. Fraietta, Vanessa E. Gonzalez, Simon F. Lacey, Adam J. Waxman, Dan T. Vogl, Wei-Ting Hwang, Sandra P. Susanibar-Adaniya, Adam D. Cohen, Alfred L. Garfall
Supplemental tables: (1) Subject characteristics. (2) Cytogenetic profiles and high-risk features. (3) Prior treatment exposures and refractoriness. (4) CAR T cell product characteristics. (5) Products that did not meet target dose. (6) Adverse event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a41bd0d88d5d4c7b561e5825c554cb6
https://doi.org/10.1158/2643-3230.22546220
https://doi.org/10.1158/2643-3230.22546220
Autor:
Edward A. Stadtmauer, Michael C. Milone, Carl H. June, Jennifer L. Brogdon, Keith G. Mansfield, Dexiu Bu, Regina M. Young, Elizabeth O. Hexner, Gerald P. Linette, Beatriz M. Carreno, Eric Lancaster, Fei Miao, Wesley V. Wilson, Megan Four, Rachel Leskowitz, Kim-Marie Shea, Angela Cosey, Regina Ferthio, Anne Marie Nelson, Andrea Brennan, Don L. Siegel, Gabriela Plesa, Rong Xu, Margaret Patchin, Robert L. Bartoszek, Natalka Koterba, Fang Chen, Lifeng Tian, Irina Kulikovskaya, Minnal Gupta, Joseph A. Fraietta, Vanessa E. Gonzalez, Simon F. Lacey, Adam J. Waxman, Dan T. Vogl, Wei-Ting Hwang, Sandra P. Susanibar-Adaniya, Adam D. Cohen, Alfred L. Garfall
We conducted a phase I clinical trial of anti-BCMA chimeric antigen receptor T cells (CART-BCMA) with or without anti-CD19 CAR T cells (huCART19) in multiple myeloma (MM) patients responding to third- or later-line therapy (phase A, N = 10) or high-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80421cf85e910d57e6c55056f662dc98
https://doi.org/10.1158/2643-3230.c.6551123.v1
https://doi.org/10.1158/2643-3230.c.6551123.v1
Autor:
J. Joseph Melenhorst, Gregory M. Chen, Meng Wang, David L. Porter, Changya Chen, McKensie A. Collins, Peng Gao, Shovik Bandyopadhyay, Hongxing Sun, Ziran Zhao, Stefan Lundh, Iulian Pruteanu-Malinici, Christopher L. Nobles, Sayantan Maji, Noelle V. Frey, Saar I. Gill, Alison W. Loren, Lifeng Tian, Irina Kulikovskaya, Minnal Gupta, David E. Ambrose, Megan M. Davis, Joseph A. Fraietta, Jennifer L. Brogdon, Regina M. Young, Anne Chew, Bruce L. Levine, Donald L. Siegel, Cécile Alanio, E. John Wherry, Frederic D. Bushman, Simon F. Lacey, Kai Tan, Carl H. June
Publikováno v:
Nature. 602:503-509
Autor:
J. Joseph Melenhorst, Gregory M. Chen, Meng Wang, David L. Porter, Changya Chen, McKensie A. Collins, Peng Gao, Shovik Bandyopadhyay, Hongxing Sun, Ziran Zhao, Stefan Lundh, Iulian Pruteanu-Malinici, Christopher L. Nobles, Sayantan Maji, Noelle V. Frey, Saar I. Gill, Alison W. Loren, Lifeng Tian, Irina Kulikovskaya, Minnal Gupta, David E. Ambrose, Megan M. Davis, Joseph A. Fraietta, Jennifer L. Brogdon, Regina M. Young, Anne Chew, Bruce L. Levine, Donald L. Siegel, Cécile Alanio, E. John Wherry, Frederic D. Bushman, Simon F. Lacey, Kai Tan, Carl H. June
Publikováno v:
Nature. 612:E22-E22
Autor:
Jamie E. DeNizio, Yan Wang, Simon F. Lacey, Vijay Bhoj, Tyler J. Reich, In-Young Jung, Regina M. Young, David L. Porter, John Scholler, Minnal Gupta, Julie K. Jadlowsky, Carl H. June, Todd Yoder, Christopher J. Ott, Megan M. Davis, Kathleen M. Haines, Irina Kulikovskaya, Golnaz Vahedi, Katherine T. Marcucci, Weimin Kong, Jun Xu, J. Joseph Melenhorst, John K. Everett, Joseph A. Fraietta, Marcela V. Maus, Erik F. Williams, Bruce L. Levine, Wenliang Wang, James E. Bradner, Rahul M. Kohli, Alexander Dimitri, Frederic D. Bushman, Maria Fasolino
Publikováno v:
J Clin Invest
Chimeric antigen receptor (CAR) T cells have induced remarkable antitumor responses in B cell malignancies. Some patients do not respond because of T cell deficiencies that hamper the expansion, persistence, and effector function of these cells. We u
Autor:
Irina Kulikovskaya, Christopher L. Nobles, Anne Chew, Shovik Bandyopadhyay, Noelle V. Frey, David L. Porter, David E Ambrose, Saar Gill, Lifeng Tian, Joseph A. Fraietta, Jennifer Brogdon, Sayantan Maji, Gregory M. Chen, Simon F. Lacey, Regina M. Young, Kai Tan, Peng Gao, Meng Wang, J. Joseph Melenhorst, Frederic D. Bushman, Cecile Alanio, Bruce L. Levine, Iulian Pruteanu-Malinici, Carl H. June, Don L. Siegel, E. J. Wherry, Megan Davis, Minnal Gupta
The adoptive transfer of T lymphocytes reprogrammed to target tumor cells has demonstrated significant potential in various malignancies. However, little is known about the long-term potential and the clonal stability of the infused cells. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::333c177c83697faf40703f5b503588c9
https://doi.org/10.21203/rs.3.rs-505891/v1
https://doi.org/10.21203/rs.3.rs-505891/v1
Autor:
J Joseph, Melenhorst, Gregory M, Chen, Meng, Wang, David L, Porter, Changya, Chen, McKensie A, Collins, Peng, Gao, Shovik, Bandyopadhyay, Hongxing, Sun, Ziran, Zhao, Stefan, Lundh, Iulian, Pruteanu-Malinici, Christopher L, Nobles, Sayantan, Maji, Noelle V, Frey, Saar I, Gill, Alison W, Loren, Lifeng, Tian, Irina, Kulikovskaya, Minnal, Gupta, David E, Ambrose, Megan M, Davis, Joseph A, Fraietta, Jennifer L, Brogdon, Regina M, Young, Anne, Chew, Bruce L, Levine, Donald L, Siegel, Cécile, Alanio, E John, Wherry, Frederic D, Bushman, Simon F, Lacey, Kai, Tan, Carl H, June
Publikováno v:
Nature. 602(7897)
The adoptive transfer of T lymphocytes reprogrammed to target tumour cells has demonstrated potential for treatment of various cancers