Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Minna U Kaikkonen"'
Autor:
Simon Leclerc, Alka Gupta, Visa Ruokolainen, Jian-Hua Chen, Kari Kunnas, Axel A Ekman, Henri Niskanen, Ilya Belevich, Helena Vihinen, Paula Turkki, Ana J Perez-Berna, Sergey Kapishnikov, Elina Mäntylä, Maria Harkiolaki, Eric Dufour, Vesa Hytönen, Eva Pereiro, Tony McEnroe, Kenneth Fahy, Minna U Kaikkonen, Eija Jokitalo, Carolyn A Larabell, Venera Weinhardt, Salla Mattola, Vesa Aho, Maija Vihinen-Ranta
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1011829 (2024)
Viruses target mitochondria to promote their replication, and infection-induced stress during the progression of infection leads to the regulation of antiviral defenses and mitochondrial metabolism which are opposed by counteracting viral factors. Th
Externí odkaz:
https://doaj.org/article/487e2f24f96c4045ac1e8396fe49fa50
Autor:
Suvi Jauhiainen, Henna Ilmonen, Pia Vuola, Heta Rasinkangas, Heidi H Pulkkinen, Sara Keränen, Miika Kiema, Jade J Liikkanen, Nihay Laham-Karam, Svetlana Laidinen, Mustafa Beter, Einari Aavik, Kimmo Lappalainen, Jouko Lohi, Johanna Aronniemi, Tiit Örd, Minna U Kaikkonen, Päivi Salminen, Erkki Tukiainen, Seppo Ylä-Herttuala, Johanna P Laakkonen
Publikováno v:
eLife, Vol 12 (2023)
Background: Sporadic venous malformation (VM) and angiomatosis of soft tissue (AST) are benign, congenital vascular anomalies affecting venous vasculature. Depending on the size and location of the lesion, symptoms vary from motility disturbances to
Externí odkaz:
https://doaj.org/article/befc893b2b91488f9cccd0243f8b744c
Autor:
Pia Laitinen, Mari-Anna Väänänen, Ida-Liisa Kolari, Petri I Mäkinen, Minna U Kaikkonen, Marc S Weinberg, Kevin V Morris, Paula Korhonen, Tarja Malm, Seppo Ylä-Herttuala, Thomas C Roberts, Mikko P Turunen, Tiia A Turunen
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265948 (2022)
MicroRNAs are well characterized in their role in silencing gene expression by targeting 3´-UTR of mRNAs in cytoplasm. However, recent studies have shown that miRNAs have a role in the regulation of genes in the nucleus, where they are abundantly lo
Externí odkaz:
https://doaj.org/article/88564874feb144f3887a8ce21294b26a
Autor:
Adrien Savy, Minna U Kaikkonen, Adrien Léger, Yohann Dickx, Lionel Galibert, Otto-Wilhelm Merten
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199866 (2018)
The human Adeno-Associated Virus serotype 2 (wtAAV2) is a common non-pathological virus and its recombinant form (rAAV) is widely used as gene therapy vector. Although rAAVs are routinely produced in the Baculovirus/Sf9 cell system, wtAAV2 has never
Externí odkaz:
https://doaj.org/article/b8e1cb9584bf4ab098e58d05e3885947
Autor:
Merja Heinäniemi, Tapio Vuorenmaa, Susanna Teppo, Minna U Kaikkonen, Maria Bouvy-Liivrand, Juha Mehtonen, Henri Niskanen, Vasilios Zachariadis, Saara Laukkanen, Thomas Liuksiala, Kaisa Teittinen, Olli Lohi
Publikováno v:
eLife, Vol 5 (2016)
Progression of malignancy to overt disease requires multiple genetic hits. Activation-induced deaminase (AID) can drive lymphomagenesis by generating off-target DNA breaks at loci that harbor highly active enhancers and display convergent transcripti
Externí odkaz:
https://doaj.org/article/3c703075f0d84e4b921da632d6e73ade
Autor:
Laure Escoubet-Lozach, Christopher Benner, Minna U Kaikkonen, Jean Lozach, Sven Heinz, Nathan J Spann, Andrea Crotti, Josh Stender, Serena Ghisletti, Donna Reichart, Christine S Cheng, Rosa Luna, Colleen Ludka, Roman Sasik, Ivan Garcia-Bassets, Alexander Hoffmann, Shankar Subramaniam, Gary Hardiman, Michael G Rosenfeld, Christopher K Glass
Publikováno v:
PLoS Genetics, Vol 7, Iss 12, p e1002401 (2011)
Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of hundreds of genes, it provides a powerful biologica
Externí odkaz:
https://doaj.org/article/f69a8d7af71742de8be55e14a6e909d9
Autor:
Andrey Anisimov, Shentong Fang, Karthik Amudhala Hemanthakumar, Tiit Örd, Kristof van Avondt, Raphael Chevre, Anu Toropainen, Prosanta Singha, Huda Gilani, Su D. Nguyen, Sinem Karaman, Emilia A. Korhonen, Ralf H. Adams, Hellmut G. Augustin, Katariina Öörni, Oliver Soehnlein, Minna U. Kaikkonen, Kari Alitalo
Publikováno v:
Nature Cardiovascular Research. 2:307-321
Leukocytes and resident cells in the arterial wall contribute to atherosclerosis, especially at sites of disturbed blood flow. Expression of endothelial Tie1 receptor tyrosine kinase is enhanced at these sites, and attenuation of its expression reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa11707359131185bee4b27b0aa7ffc
https://doi.org/10.1038/s44161-023-00224-y
https://doi.org/10.1038/s44161-023-00224-y
Autor:
Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T. Lee, David Z. Pan, Zong Miao, Sankha Subhra Das, Dorota Kaminska, Tiit Örd, Jihane N. Benhammou, Martin Wabitsch, Joseph R. Pisegna, Ville Männistö, Kirsi H. Pietiläinen, Markku Laakso, Janet S. Sinsheimer, Minna U. Kaikkonen, Jussi Pihlajamäki, Päivi Pajukanta
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue functions, preventing efficient fat storage, and thus driving ectopic fat acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e978e5c7684af3edcace9dcec0d5b474
https://escholarship.org/uc/item/29h649mt
https://escholarship.org/uc/item/29h649mt
Autor:
Tiit Örd, Tapio Lönnberg, Valtteri Nurminen, Aarthi Ravindran, Henri Niskanen, Miika Kiema, Kadri Õunap, Maleeha Maria, Pierre R. Moreau, Pashupati P. Mishra, Senthil Palani, Jenni Virta, Heidi Liljenbäck, Einari Aavik, Anne Roivainen, Seppo Ylä-Herttuala, Johanna P. Laakkonen, Terho Lehtimäki, Minna U. Kaikkonen
Coronary artery disease (CAD) is a pandemic disease where up to half of the risk is explained by genetic factors. Advanced insights into the genetic basis of CAD require deeper understanding of the contributions of different cell types, molecular pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78c214be7d8377e7da7e5077050758b
https://trepo.tuni.fi/handle/10024/149229
https://trepo.tuni.fi/handle/10024/149229
Autor:
Anna-Liisa Levonen, Seppo Ylä-Herttuala, Minna U. Kaikkonen, Hanna P. Lesch, Haritha Samaranayake, Jari P. Lappalainen, Jere T. Pikkarainen, Emilia Kansanen, Suvi M. Kuosmanen, Heidi M. Laitinen, Ann-Marie Määttä, Anna-Kaisa Ruotsalainen, Hanna M. Leinonen
Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that regulates protection against a wide variety of toxic insults to cells, including cytotoxic cancer chemotherapeutic drugs. Many lung cancer cells harbor a mutation in ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90bf3aae97f86781220c782bc7ad87cf
https://doi.org/10.1158/0008-5472.c.6503937.v1
https://doi.org/10.1158/0008-5472.c.6503937.v1