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Akademický článek

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer

Autor: Minna Sopo, Maarit Anttila, Kirsi Hämäläinen, Annukka Kivelä, Seppo Ylä-Herttuala, Veli-Matti Kosma, Leea Keski-Nisula, Hanna Sallinen

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)

Abstract Background In many malignancies including ovarian cancer, different angiogenic factors have been related to poor prognosis. However, data on their relations to each other or importance as a prognostic factor in ovarian cancer is missing. The

Externí odkaz: https://doaj.org/article/c5c886524d45442282fe00d193bfa571

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Akademický článek

High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer.

Autor: Minna Sopo, Hanna Sallinen, Kirsi Hämäläinen, Annukka Kivelä, Seppo Ylä-Herttuala, Veli-Matti Kosma, Leea Keski-Nisula, Maarit Anttila

Publikováno v: PLoS ONE, Vol 15, Iss 11, p e0241484 (2020)

BackgroundAntiangiogenic therapy, although part of standard treatment in ovarian cancer, has variable efficacy. Furthermore, little is known about the prognostic biomarkers and factors influencing angiogenesis in cancer tissue. We evaluated the expre

Externí odkaz: https://doaj.org/article/69826e2911394dc789a50d4ef4ac0f56

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High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer

Autor: Veli-Matti Kosma, Maarit Anttila, Kirsi Hämäläinen, Leea Keski-Nisula, Minna Sopo, Hanna Sallinen, Annukka M. Kivelä, Seppo Ylä-Herttuala

Publikováno v: PLoS ONE, Vol 15, Iss 11, p e0241484 (2020)
PLoS ONE

Background Antiangiogenic therapy, although part of standard treatment in ovarian cancer, has variable efficacy. Furthermore, little is known about the prognostic biomarkers and factors influencing angiogenesis in cancer tissue. We evaluated the expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6b44c4c85ba0de979545564a935312
https://doi.org/10.1371/journal.pone.0241484

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Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma

Autor: Minna Sopo, Maarit Anttila, Hanna Sallinen, Laura Tuppurainen, Anniina Laurema, Svetlana Laidinen, Kirsi Hamalainen, Pasi Tuunanen, Jonna K. Koponen, Veli-Matti Kosma, Seppo Heinonen, Kari Alitalo, Seppo Yla-Herttuala

Publikováno v: International journal of cancer. 131(10)

We compared effects of antiangiogenic gene therapy with a combination of soluble sVEGFR-1, sVEGFR-2 and sVEGFR-3 to chemotherapy with carboplatin and paclitaxel and to antiangiogenic monoclonal anti-VEGF-antibody bevacizumab in an intraperitoneal ova

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa07133dbf0e5b30e8b61017dd5b122
https://pubmed.ncbi.nlm.nih.gov/22336998

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