Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Minna Schmidt"'
Autor:
Daniel S Evans, Monique N O'Leary, Ryan Murphy, Minna Schmidt, Kristin Koenig, Michael Presley, Brittany Garrett, Ha‐Neui Kim, Li Han, Emmeline C Academia, Matt J Laye, Daniel Edgar, Christopher A Zambataro, Tracey Barhydt, Colleen M Dewey, Jarrott Mayfield, Joy Wilson, Silvestre Alavez, Mark Lucanic, Brian K Kennedy, Maria Almeida, Julie K Andersen, Pankaj Kapahi, Gordon J Lithgow, Simon Melov
Publikováno v:
JBMR Plus, Vol 5, Iss 3, Pp n/a-n/a (2021)
ABSTRACT Aging is characterized by systemic declines in tissue and organ functions. Interventions that slow these declines represent promising therapeutics to protect against age‐related disease and improve the quality of life. In this study, sever
Externí odkaz:
https://doaj.org/article/1488f0e2d6454063828ddeb29690b6a6
Autor:
Nikhita Anand, Angelina Holcom, Michael Broussalian, Minna Schmidt, Shankar J. Chinta, Gordon J. Lithgow, Julie K. Andersen, Manish Chamoli
Publikováno v:
Neurobiology of Disease, Vol 139, Iss , Pp 104786- (2020)
Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson's disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced neuro
Externí odkaz:
https://doaj.org/article/960f8ce2435743688e358ea2dfa5510f
Autor:
Cyrene Arputhasamy, Anna C. Foulger, Mark Lucanic, Anand Rane, Minna Schmidt, Theo Garrett, Michael Broussalian, Elena Battistoni, Rachel B. Brem, Gordon J. Lithgow, Manish Chamoli, Julie K. Andersen
Publikováno v:
GeroScience
Lysosomes are crucial for degradation and recycling of damaged proteins and cellular components. Therapeutic strategies enhancing lysosomal function are a promising approach for aging and age-related neurodegenerative diseases. Here, we show that an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d695f60b6eeea96ebb11d48a0c5d1829
https://doi.org/10.1007/s11357-022-00647-8
https://doi.org/10.1007/s11357-022-00647-8
Autor:
Manish Chamoli, Anand Rane, Shankar Chinta, Azar Shahmirzadi, Caroline Kumsta, Dhanya Nambiar, David Hall, Anna Foulger, Suzanne Angeli, Minna Schmidt, Sharon Pitteri, Malene Hansen, Gordon Lithgow, Julie Andersen
Autophagy-lysosomal function maintains healthy lifespan and ameliorates disease pathologies in diverse model organisms. An important master regulator of the autophagy-lysosomal pathway is an evolutionary conserved transcription factor EB (TFEB). Decl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b6eea0f3a8c97f1f6a62b7f535cf856
https://doi.org/10.21203/rs.3.rs-1840028/v1
https://doi.org/10.21203/rs.3.rs-1840028/v1
Autor:
Gordon J. Lithgow, Michael Broussalian, Anand Rane, Julie K. Andersen, Cyrene Arputhasamy, Theo Garett, Manish Chamoli, Rachel B. Brem, Anna C. Foulger, Elena Battistoni, Minna Schmidt, Mark Lucanic
Lysosomes are crucial for degradation and recycling of damaged proteins and cellular components. Therapeutic strategies enhancing lysosomal function are a promising approach for aging and age-related neurodegenerative diseases. Here, we show that an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77ffafd319382ffd35b193048f2cfb17
https://doi.org/10.1101/2021.10.21.465344
https://doi.org/10.1101/2021.10.21.465344
Autor:
Angelina Holcom, Gordon J. Lithgow, Minna Schmidt, Nikhita Anand, Manish Chamoli, Michael Broussalian, Julie K. Andersen, Shankar J. Chinta
Publikováno v:
Neurobiology of Disease, Vol 139, Iss, Pp 104786-(2020)
Neurobiol Dis
Neurobiol Dis
Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson’s disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77eb563ab3d2eb2743976a22a9db5c01
https://doi.org/10.1016/j.nbd.2020.104786
https://doi.org/10.1016/j.nbd.2020.104786
An important characteristic feature of aging and many age-related neurodegenerative diseases is a loss of protein homeostasis (proteostasis), which is accompanied by increased accumulation of damaged, misfolded and aggregated proteins. One of the vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebf27d86037038137284bb3f385525d
https://europepmc.org/articles/PMC6184110/
https://europepmc.org/articles/PMC6184110/