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Autor:
Laura Sandra Lello, Mona H. Fenstad, Marc P. Windisch, Minna Poranen, Valentyn Oksenych, Eva Zusinaite, Tanel Tenson, Rouan Yao, Kirsti Løseth, Svein Arne Nordbø, Astra Vitkauskiene, Eunji Jo, Aleksandr Ianevski, Denis E. Kainov, Wei Wang, Gunnveig Grødeland, Marius Trøseid, Erlend Ravlo, Jaewon Yang, Pål Aukrust, Anni I Nieminen, Hilde Lysvand, Sainan Wang, Nicolas Legrand, Anu Kantele, Andres Merits, Magnar Bjørås
Antiviral drugs are powerful tools to combat emerging viral diseases, one of the leading causes of morbidity and mortality in the world. However, most existing antivirals have failed to cure COVID-19. Accordingly, there is an urgent need for new ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff386159b9cda104ea7cbdf7a0b5d0bb
https://doi.org/10.21203/rs.3.rs-189394/v1
https://doi.org/10.21203/rs.3.rs-189394/v1
Autor:
Tanel Tenson, Erlend Ravlo, Jaewon Yang, Valentyn Oksenych, Hilde Lysvand, Laura Sandra Lello, Minna Poranen, Anni I Nieminen, Rouan Yao, Astra Vitkauskiene, Sainan Wang, Wei Wang, Marius Trøseid, Pål Aukrust, Andres Merits, Eva Zusinaite, Aleksandr Ianevski, Denis E. Kainov, Nicolas Legrand, Anu Kantele, Eunji Jo, Kirsti Løseth, Gunnveig Grødeland, Mona H. Fenstad, Marc P. Windisch, Magnar Bjørås, Svein Arne Nordbø
There is an urgent need for new antivirals with powerful therapeutic potential and tolerable side effects. In the present study, we found that recombinant human interferon-alpha (IFNa) triggers intrinsic and extrinsic cellular antiviral responses, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f0bde4692d34b599900ad01f9a056e4
https://doi.org/10.1101/2021.01.05.425331
https://doi.org/10.1101/2021.01.05.425331
Publikováno v:
Journal of Chromatography A. 1574:50-59
Steric exclusion chromatography (SXC) is a method for separation of large target solutes based on their association with a hydrophilic stationary phase through mutual steric exclusion of polyethylene glycol (PEG). Selectivity in SXC is determined by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fbbb2854e31fdd43d64c59f2482cd3
https://doi.org/10.1016/j.chroma.2018.08.063
https://doi.org/10.1016/j.chroma.2018.08.063
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates. Whether RNAi naturally protects humans from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67028a5d2f1ecce7542caad816cdd0cf
https://doi.org/10.3389/fmicb.2018.02151
https://doi.org/10.3389/fmicb.2018.02151
Publikováno v:
Journal of chromatography. A. 1278
Recent advances in the field of RNA interference and new cost-effective approaches for large-scale double-stranded RNA (dsRNA) synthesis have fuelled the demand for robust high-performance purification techniques suitable for dsRNA molecules of vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293f83a5888f0598d444996b0b7f1f25
https://pubmed.ncbi.nlm.nih.gov/23332782
https://pubmed.ncbi.nlm.nih.gov/23332782
Publikováno v:
University of Helsinki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2bbc07c9733a120ba556c56a389880e2
https://researchportal.helsinki.fi/en/publications/4f27a88f-6f94-402e-b0eb-a21832eb43e5
https://researchportal.helsinki.fi/en/publications/4f27a88f-6f94-402e-b0eb-a21832eb43e5
Publikováno v:
University of Helsinki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5ff6b6cc0265350f2f04ab99531c35fa
https://researchportal.helsinki.fi/en/publications/5e51c91b-7613-4359-8f25-1c5152adf544
https://researchportal.helsinki.fi/en/publications/5e51c91b-7613-4359-8f25-1c5152adf544