Novel Treatment for Glioblastoma Delivered by a Radiation Responsive and Radiopaque Hydrogel

Autor: Kimberly Taing, Deeksha Saxena, Mathilde Bouché, Yuxi C. Dong, Ryan D Salinas, Hongjun Song, Jay F. Dorsey, Minna H. Chen, Jason A. Burdick, Jessica C. Hsu, Saad Sheikh, David P. Cormode

Publikováno v: ACS Biomater Sci Eng
ACS Biomaterials Science and Engineering
ACS Biomaterials Science and Engineering, ACS, 2021, 7 (7), pp.3209-3220. ⟨10.1021/acsbiomaterials.1c00385⟩

Successful treatment of glioblastoma (GBM) is hampered by primary tumor recurrence after surgical resection and poor prognosis, despite adjuvant radiotherapy and chemotherapy. In search of improved outcomes for this disease, quisinostat appeared as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d48162b31741efcbc4e31b8bf1fca9
https://pubmed.ncbi.nlm.nih.gov/34160196

Delivery of progenitor cells with injectable shear-thinning hydrogel maintains geometry and normalizes strain to stabilize cardiac function after ischemia

Autor: Chantel M. Venkataraman, Ann C. Gaffey, Susan M. Schultz, Pavan Atluri, Alen Trubelja, Minna H. Chen, Jason A. Burdick, Chandra M. Sehgal, Jennifer J. Chung, Carol W. Chen

Publikováno v: J Thorac Cardiovasc Surg

Objectives The ventricle undergoes adverse remodeling after myocardial infarction, resulting in abnormal biomechanics and decreased function. We hypothesize that tissue-engineered therapy could minimize postischemic remodeling through mechanical stre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a45b1324439b88045471de78b10679
https://europepmc.org/articles/PMC7769598/

Reversible Control of Network Properties in Azobenzene-Containing Hyaluronic Acid-Based Hydrogels

Autor: Adrianne M. Rosales, Christopher B. Rodell, Jason A. Burdick, Matthew G. Morrow, Kristi S. Anseth, Minna H. Chen

Publikováno v: Bioconjugate chemistry. 29(4)

Biomimetic hydrogels fabricated from biologically derived polymers, such as hyaluronic acid (HA), are useful for numerous biomedical applications. Due to the dynamic nature of biological processes, it is of great interest to synthesize hydrogels with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2fb2dd6a92e8d9bcbb959d8e17906c
https://pubmed.ncbi.nlm.nih.gov/29406696

3496 Mesenchymal Stem Cell Extracellular Vesicle Delivery in a Shear-Thinning Hydrogel For Therapy in an Acute Myocardial Infarction Model: A Comparative Analysis

Autor: Zoe Tran, Elizabeth C. Li, Samuel Kim, Drew Goldberg, Minna H. Chen, Pavan Atluri, Jason P. Burdick, Ann C. Gaffey

Publikováno v: Journal of Clinical and Translational Science

OBJECTIVES/SPECIFIC AIMS: The primary aim is to assess differences in therapeutic effect between MSC and EPC EVs on acute ischemic rat hearts through delivery in a biocompatible and shear-thinning hydrogel. Primary outcomes for therapeutic assessment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db21433ce6352e1f5b12ea4966dac843
http://europepmc.org/articles/PMC6799174

Abstract 17861: Injectable Shear-thinning Hydrogels to Deliver Endothelial Progenitor Cells, Reduce Ventricular Strain, and Dynamic Stiffness to Stabilize Cardiac Function Following Ischemic Injury

Autor: Ann C Gaffey, Minna H Chen, Alen Trubelja, Chantel M Venkataraman, Carol W Chen, Susan S, Chandra M Sehgal, Jason A Burdick, Pavan Atluri

Publikováno v: Circulation. 132

The ventricle undergoes adverse remodeling, post-infarction. We developed an injectable shear-thinning hyaluronic acid hydrogel(STG) and endothelial progenitor cell construct(STG-EPC) to enhance vasculogenesis(shown previously) and mechanically stabi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b518d324af41750f13e21ae7fe5d591
https://doi.org/10.1161/circ.132.suppl_3.17861