Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Minna Groenning"'
Autor:
Bente Vestergaard, Minna Groenning, Manfred Roessle, Jette S Kastrup, Marco van de Weert, James M Flink, Sven Frokjaer, Michael Gajhede, Dmitri I Svergun
Publikováno v:
PLoS Biology, Vol 5, Iss 5, p e134 (2007)
Although amyloid fibrillation is generally believed to be a nucleation-dependent process, the nuclei are largely structurally uncharacterized. This is in part due to the inherent experimental challenge associated with structural descriptions of indiv
Externí odkaz:
https://doaj.org/article/89b0e02fe477418e86bcc845bb0617d8
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2551
Inducing protein aggregation in vitro under various formulation and stress conditions may lead to an increased understanding of the different association routes a protein can undergo. However, a range of factors can affect the aggregation process, of
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3172401300e666d37a07bb4a6ec46266
https://doi.org/10.1007/978-1-0716-2597-2_20
https://doi.org/10.1007/978-1-0716-2597-2_20
Autor:
Camilla Thorlaksen, Heidi S. Schultz, Simon K. Gammelgaard, Wim Jiskoot, Nikos S. Hatzakis, Flemming S. Nielsen, Helene Solberg, Vito Foderà, Christina Bartholdy, Minna Groenning
Publikováno v:
Thorlaksen, C, Schultz, H S, Gammelgaard, S K, Jiskoot, W, Hatzakis, N S, Nielsen, F S, Solberg, H, Foderà, V, Bartholdy, C & Groenning, M 2023, ' In vitro and in vivo immunogenicity assessment of protein aggregate characteristics ', International Journal of Pharmaceutics, vol. 631, 122490 . https://doi.org/10.1016/j.ijpharm.2022.122490
International Journal of Pharmaceutics, 631:122490
International Journal of Pharmaceutics, 631:122490
The immunogenicity risk of therapeutic protein aggregates has been extensively investigated over the past decades. While it is established that not all aggregates are equally immunogenic, the specific aggregate characteristics, which are most likely
Autor:
Camilla Thorlaksen, Adriana-Maria Stanciu, Martin Busch Neergaard, Wim Jiskoot, Minna Groenning, Vito Foderà
Publikováno v:
Thorlaksen, C, Stanciu, A-M, Neergaard, M B, Jiskoot, W, Groenning, M & Fodera, V 2022, ' Subtle pH variation around pH 4.0 affects aggregation kinetics and aggregate characteristics of recombinant human insulin ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 179, pp. 166-172 . https://doi.org/10.1016/j.ejpb.2022.09.001
European Journal of Pharmaceutics and Biopharmaceutics, 179, 166-172
European Journal of Pharmaceutics and Biopharmaceutics, 179, 166-172
Insulin is a biotherapeutic protein, which, depending on environmental conditions such as pH, has been shown to form a large variety of aggregates with different structures and morphologies. This work focuses on the formation and characteristics of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91be14b431bb1a70f378f1ba6f7563eb
https://curis.ku.dk/ws/files/321608778/1_s2.0_S0939641122001904_main.pdf
https://curis.ku.dk/ws/files/321608778/1_s2.0_S0939641122001904_main.pdf
Publikováno v:
Journal of Pharmaceutical Sciences. 107:1842-1851
Regulatory authorities and scientific communities are increasingly attentive to the known and universal presence of small particulates in biological drug products. The underlying concern is that these particulates may cause unwanted formation of anti
Autor:
Minna Groenning, Andreas van Maarschalkerweerd, Romà Tauler, Pau Bernadó, Bente Vestergaard, Fátima Herranz-Trillo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Formation of amyloids is the hallmark of several neurodegenerative pathologies. Structural investigation of these complex transformation processes poses significant experimental challenges due to the co-existence of multiple species. The additive nat
Publikováno v:
Journal of pharmaceutical sciences. 108(9)
Protein fibrils are of great interest due to their involvement in several pathologies and their roles in the degradation of many therapeutic protein products. Fibrils share highly similar secondary structural motifs across different proteins and appl
Autor:
Minna Groenning, Eva Horn Møller, Malthe Møhl Schack, Thomas Rades, Anders V. Friderichsen, John F. Carpenter
Publikováno v:
Journal of pharmaceutical sciences. 108(3)
The analysis of subvisible particles is currently challenging but pivotal to the understanding and control of the quality of protein therapeutics. While a range of characterization methods is available for subvisible particles, information on the pro
Autor:
Martin Alm, Merete Hedemark Vestergaard, Hanne Mørck Nielsen, Minna Groenning, Søren Langer Steffensen, Henrik Franzyk
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 94:305-311
Bacterial colonization and biofilm formation on medical devices constitute major challenges in clinical long-term use of e.g. catheters due to the risk of (re)infection of patients, which would result in additional use of antibiotics risking bacteria