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Akademický článek

IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs

Publikováno v: eLife, Vol 6 (2017)

Expression of inflammatory genes is determined in part by post-transcriptional regulation of mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence is poorly understood. Here, we report a novel pathway in which LPS/TLR4 e

Externí odkaz: https://doaj.org/article/5b84f1b2b69f41da8fc9474e0ca9c10d

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Akademický článek

Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress signaling.

Autor: Samir Benosman, Palaniyandi Ravanan, Ricardo G Correa, Ying-Chen Hou, Minjia Yu, Muhammet Fatih Gulen, Xiaoxia Li, James Thomas, Michael Cuddy, Yasuko Matsuzawa, Renata Sano, Paul Diaz, Shu-ichi Matsuzawa, John C Reed

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64256 (2013)

Endoplasmic reticulum (ER) stress occurs when unfolded proteins accumulate in the lumen of the organelle, triggering signal transduction events that contribute either to cellular adaptation and recovery or alternatively to cellular dysfunction and de

Externí odkaz: https://doaj.org/article/4d4f45f4471b456ba8e677bb32ce1c62

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IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes

Publikováno v: Nature immunology

Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we report an unconventional IL-1R–MyD88–IRAK2–PHB/OPA1 signaling axis that reprograms mitochondrial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a053a95924e4916f12d9c9947108d22
http://europepmc.org/articles/PMC7566776

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Akademický článek

Osteosarcoma-targeted Cu and Ce based oxide nanoplatform for NIR II fluorescence/magnetic resonance dual-mode imaging and ros cascade amplification along with immunotherapy

Autor: Mo Cheng, Qingjie Kong, Qing Tian, Weiluo Cai, Chunmeng Wang, Minjia Yuan, Wenxing Wang, Peiyuan Wang, Wangjun Yan

Publikováno v: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-16 (2024)

Abstract Background As the lethal bone tumor, osteosarcoma often frequently occurs in children and adolescents with locally destructive and high metastasis. Distinctive kinds of nanoplatform with high therapeutical effect and precise diagnosis for os

Externí odkaz: https://doaj.org/article/b3c0b2e3f35d4567b7818d2d5558c6a6

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Akademický článek

Physical–Chemical Coupling Coassembly Approach to Branched Magnetic Mesoporous Nanochains with Adjustable Surface Roughness

Autor: Xirui Huang, Minchao Liu, Qianqian Lu, Kexin Lv, Lipeng Wang, Sixing Yin, Minjia Yuan, Qi Li, Xiaomin Li, Tiancong Zhao, Dongyuan Zhao

Publikováno v: Advanced Science, Vol 11, Iss 23, Pp n/a-n/a (2024)

Abstract Self‐assembly processes triggered by physical or chemical driving forces have been applied to fabricate hierarchical materials with subtle nanostructures. However, various physicochemical processes often interfere with each other, and thei

Externí odkaz: https://doaj.org/article/261745b8482a49648f8c6df485aa8b79

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Inhibition of IRAK4 kinase activity improves ethanol-induced liver injury in mice

Autor: Dhweeja Dasarathy, Doug Czarnecki, Yun Liao, Xiaoxia Li, Jinbo Yang, Xing Chen, Kyle L. Poulsen, Junjie Zhao, Hao Zhou, Minjia Yu, Vanessa Taylor, Quanri Zhang, Han Wang, Daniela S. Allende, Lingzi Hong, Megan R. McMullen, Laura E. Nagy

Publikováno v: J Hepatol

Backgrounds & Aims Alcohol-related liver disease (ALD) is a major cause of chronic liver disease worldwide with limited therapeutic options. Interleukin-1 receptor associated kinase 4 (IRAK4), the master kinase of Toll-like receptor (TLR)/IL-1R-media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba554ba0beef218fcc69b2fc039bce66
https://europepmc.org/articles/PMC8007112/

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Heparin inhibits proinflammatory and promotes anti-inflammatory macrophage polarization under hyperglycemic stress

Autor: Xiaoxia Li, Amina Abbadi, Jacqueline Loftis, Yan Wang, Sajina Shakya, Minjia Yu, Aimin Wang, Vincent C. Hascall, Edward V. Maytin

Publikováno v: J Biol Chem

Monocytes are rapidly recruited to sites of diabetic complications and differentiate into macrophages. Previously, we showed that rat kidney mesangial cells dividing during hyperglycemic stress abnormally synthesize hyaluronan (HA) in intracellular c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf44ae4780239966756159f442485f05
https://europepmc.org/articles/PMC7152777/

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IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs

Publikováno v: eLife
eLife, Vol 6 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092f26a9c11ef7084a7e3e90d9a51255
http://europepmc.org/articles/PMC5675595

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MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases

Publikováno v: The Journal of Experimental Medicine
The Journal of experimental medicine, vol 211, iss 5

MyD88-dependent GM-CSF production by endothelial cells plays a role in the initiation of obesity-associated inflammation by promoting adipose macrophage recruitment and M1-like polarization.
Low-grade systemic inflammation is often associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48569c6c70fe0604a249dccbb94e182
http://europepmc.org/articles/PMC4010914

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