Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Minireview—Computational Analysis of GPCRs"'
Autor:
Alexandra E. Conibear, Eamonn Kelly
Publikováno v:
Mol Pharmacol
The field of biased agonism has grown substantially in recent years and the μ-opioid receptor has been one of the most intensively studied receptor targets for developing biased agonists. Yet, despite extensive research efforts, the development of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272bfffea7ac4b54c6dceeace6867c89
https://doi.org/10.1124/mol.119.115956
https://doi.org/10.1124/mol.119.115956
Publikováno v:
Mol Pharmacol
The ligand-binding sites of many G protein-coupled receptors (GPCRs) are situated around and deeply embedded within the central pocket formed by their seven transmembrane-spanning α-helical domains. Generally, these binding sites are assumed accessi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3923aa03a36ab01e443ecfb240c06083
https://doi.org/10.1124/mol.118.115113
https://doi.org/10.1124/mol.118.115113
Publikováno v:
Mol Pharmacol
Many physiologic processes are controlled through the activation of G protein-coupled receptors (GPCRs) by regulatory peptides, making peptide GPCRs particularly useful targets for major human diseases such as diabetes and cancer. Peptide GPCRs are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e212b47e51e11a783985c6663430dc04
https://pubmed.ncbi.nlm.nih.gov/31436539
https://pubmed.ncbi.nlm.nih.gov/31436539