Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Minilik Angagaw"'
Autor:
Jan-Rung Mo, Anjili Mathur, Minilik Angagaw, Shuxia Zhao, Yuxun Wang, Diana Gargano, Alessandra DiBacco, Eric S Bachman
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7286 (2009)
Splenic enlargement (splenomegaly) develops in numerous disease states, although a specific pathogenic role for the spleen has rarely been described. In polycythemia vera (PV), an activating mutation in Janus kinase 2 (JAK2(V617)) induces splenomegal
Externí odkaz:
https://doaj.org/article/710f5ab188684f0988a70f6dc513a604
Autor:
Manfred Kraus, Jannik N. Andersen, Peter Blume-Jensen, Nancy Kohl, Victoria Richon, Giulio Draetta, Martin L. Scott, Roderick T. Bronson, Shailaja Kasibhatla, Ekaterina V. Bobkova, Alan Northrup, Thomas F. Vogt, Myung K. Shin, Melissa Hurd, Paula Andrade, Erica Leccese, Minilik Angagaw, Nirah H. Shomer, Diana Gargano, Alessandra Di Bacco, Yusuf Erkul, Erin O'Hare, Kumiko Nagashima, Kun Hu, Yamicia Connor, Brian Dolinski, Kaiko Kunii, Heike Keilhack, Katharine Ellwood-Yen
Supplementary Figures 1-4 from PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828919a62a5a02040e157eb5ac219fb4
https://doi.org/10.1158/0008-5472.22390089
https://doi.org/10.1158/0008-5472.22390089
Autor:
Pradip K. Majumder, Cyrille Sur, John F. Reilly, Shailaja Kasibhatla, Kimberly A. Bettano, Jason Laskey, Minilik Angagaw, Jennifer Tammam, Chris Ware, Clay L. Efferson, Joe Zhu, Weisheng Zhang
Supplementary Figures 1-4 from Inhibition of Tumor Growth Progression by Antiandrogens and mTOR Inhibitor in a Pten-Deficient Mouse Model of Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24945cb1efd12c18ab73cb9bddf2d092
https://doi.org/10.1158/0008-5472.22378566
https://doi.org/10.1158/0008-5472.22378566
Autor:
Liming Liu, Jason Laskey, Raymond J. Moniz, Toya Nath Baral, Joann A. O'Connor, Archie Tse, Andrey Loboda, Robbie L. McLeod, Mike Lee, Minilik Angagaw, Jin-Hwan Han, SuChun Hsieh, Juha Punnonen, Sarah Javaid, Svetlana Sadekova, Hassan Issafras
Publikováno v:
Oncotarget
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has been reported to mediate both tumorigenic and anti-tumor effects in vivo. Blockade of the CEACAM1 signaling pathway has recently been implicated as a novel mechanism for cancer i
Autor:
Shuxia Zhao, Paul Kirschmeier, Ulrike Philippar, Li Xiao, Wang James J-S, Boga Sobhana Babu, Pierre Daublain, Phieng Siliphaivanh, Priya Dayananth, Clifford Restaino, Donna Carr, Lata Jayaraman, Xiaolei Gao, Marc Pelletier, Ling Zhang, Bart Lutterbach, Erick J. Morris, Stuart Black, Rumin Zhang, Weihong Jin, Ahmed A. Samatar, Joe Kelly, Daniel J. Hicklin, Alan B. Cooper, Leigh Zawel, Liang Zhu, Brian Long, Elaine M. Pinheiro, Hugh Y. Zhu, Sharda Jha, Stephen Fawell, Sunil Paliwal, D. Gary Gilliland, Jenny Liu, William T. Windsor, David J. Witter, Edward DiNunzio, Yongi Deng, W. Robert Bishop, Minilik Angagaw, Desai Jagdish A, Alan Hruza, Gerald W. Shipps
Publikováno v:
Cancer Discovery. 3:742-750
The high frequency of activating RAS or BRAF mutations in cancer provides strong rationale for targeting the mitogen-activated protein kinase (MAPK) pathway. Selective BRAF and MAP-ERK kinase (MEK) inhibitors have shown clinical efficacy in patients
Autor:
Minilik Angagaw, Kaiko Kunii, Leigh Zawel, Marlene C. Hinton, Chris Winter, Weisheng Zhang, Christopher Ware, Clay L. Efferson, Cloud P. Paweletz, Stephen Fawell, Jennifer Tammam, Brian B. Haines, Pradip K. Majumder, Theresa Zhang, Jonathan D. Cheng, Sriram Sathyanarayanan, Heike Keilhack, Joe Zhu, Gary Gilliland
Publikováno v:
Translational Oncology. 5(6):422-429
Activation of the phosphoinositide 3-kinase pathway is commonly observed in human prostate cancer. Loss of function of phosphatase and tensin homolog (PTEN) is associated with the activation of AKT and mammalian target of rapamycin (mTOR) in many can
Autor:
Bin Zhan, Leroy Versteeg, Zhuyun Liu, Janice D Woodhouse, Coreen M. Beaumier, Minilik Angagaw, Xavier Le Guezennec, Subhabrata Biswas
Publikováno v:
Journal of immunological methods. 440
Luminex® technology provides a powerful methodology for multiplex cytokine detection but remains constrained by high costs and a minimum of 25-50μL sample volume requirement per assay-well often hindering analysis of limited biological samples. Her
Autor:
George N. Nikov, Grace Bi, Benito Munoz, Matthew G. Stanton, Matthew T. Tudge, Richard E. Middleton, Jamie L. Crispino, Peter Sajonz, Mark S. Shearman, Black Regina M, Minilik Angagaw, Paula Andrade, Eric Fan, Flobert Tanga, Jonathan C. Cruz, Alexander A. Szewczak, Nirah H. Shomer, Bethany Hughes, Sanjiv J. Shah, Georgia Farris, Christopher Hamblett, Jed L. Hubbs, David L. Sloman, Candia M. Kenific
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:755-758
We report herein a novel series of difluoropiperidine acetic acids as modulators of gamma-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was facilitated by a unique and selective beta-difluorination with Selectfluor. Compounds 1f and 2
Autor:
Christopher Winter, X Dai, Christopher Ware, Jennifer O'Neil, Candia M. Kenific, John F. Reilly, J Gorenstein, George N. Nikov, Peter Strack, Nancy E. Kohl, Clay L. Efferson, KJ Leach, J Hardwick, Han Sang Kim, C Elbi, Jennifer Tammam, Giulio F. Draetta, Kaiko Kunii, T Look, Lht Van der Ploeg, J Zhao, Sudhir Rao, Pradip K. Majumder, Xianlu Qu, Martin L. Scott, L Bristow, Minilik Angagaw
Publikováno v:
British Journal of Pharmacology. 158:1183-1195
Background and purpose: γ-Secretase inhibitors (GSIs) block NOTCH receptor cleavage and pathway activation and have been under clinical evaluation for the treatment of malignancies such as T-cell acute lymphoblastic leukaemia (T-ALL). The ability of
Autor:
Shailaja Kasibhatla, Jennifer Tammam, Cyrille Sur, Christopher Ware, Joe Zhu, Pradip K. Majumder, Kimberly A. Bettano, Minilik Angagaw, Jason Laskey, Clay L. Efferson, Weisheng Zhang, John F. Reilly
Publikováno v:
Cancer Research. 69:7466-7472
Androgen receptors have been shown to play a critical role in prostate cancer. We used ultrasound imaging techniques to track tumor response to antiandrogen and rapamycin treatment in a prostate-specific Pten-deleted mouse model of cancer. Depletion