Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Minigastrin"'
Autor:
Nadine Holzleitner, Sebastian Fischer, Isabel Maniyankerikalam, Roswitha Beck, Constantin Lapa, Hans-Jürgen Wester, Thomas Günther
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Background We recently introduced radiohybrid (rh)-based minigastrin analogs e.g., DOTA-rhCCK-18 (DOTA-D-Dap(p-SiFA)-(D-γ-Glu)8-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH2), that revealed substantially increased activity retention in the tumor. However
Externí odkaz:
https://doaj.org/article/793c094f567543f6a4050d4c4b105f85
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Background Over the last years, several strategies have been reported to improve the metabolic stability of minigastrin analogs. However, currently applied compounds still reveal limited in vitro and in vivo stability. We thus performed a gl
Externí odkaz:
https://doaj.org/article/b2cf2f4f6b9c494c9c68d658fa804ed7
Akademický článek
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Autor:
Michal Grzmil, Paul Boersema, Ashish Sharma, Alain Blanc, Stefan Imobersteg, Martin Pruschy, Paola Picotti, Roger Schibli, Martin Behe
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-5 (2022)
Abstract The vast majority of our knowledge regarding cancer radiobiology and the activation of radioresistance mechanisms emerged from studies using external beam radiation therapy (EBRT). Yet, less is known about the cancer response to internal tar
Externí odkaz:
https://doaj.org/article/bac256bf9020417aa488a6d6235cc1ac
Autor:
Rosalba Mansi, Melpomene Fani
Publikováno v:
CHIMIA, Vol 75, Iss 6, Pp 500-504 (2021)
Radiolabeled peptides can deliver radiation selectively to tumors via targeting peptide receptors that are overexpressed on the surface of cancer cells. The radiation is used either for detection (imaging) or for destruction (therapy) of these tumors
Externí odkaz:
https://doaj.org/article/343cb6970b6e441aa1faeb8c109cecea
Publikováno v:
CHIMIA, Vol 74, Iss 12, Pp 939-945 (2020)
he concept of targeted radionuclide therapy (TRT) is the accurate and efficient delivery of radiation to disseminated cancer lesions while minimizing damage to healthy tissue and organs. Critical aspects for successful development of novel radiopharm
Externí odkaz:
https://doaj.org/article/97be37d64a124883b7720a8526c2d4d5
Autor:
Thomas Günther, Nadine Holzleitner, Daniel Di Carlo, Nicole Urtz-Urban, Constantin Lapa, Hans-Jürgen Wester
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 826 (2023)
In order to optimize elevated kidney retention of previously reported minigastrin derivatives, we substituted (R)-DOTAGA by DOTA in (R)-DOTAGA-rhCCK-16/-18. CCK-2R-mediated internalization and affinity of the new compounds were determined using AR42J
Externí odkaz:
https://doaj.org/article/0ad4ec33a1eb49969fc2e2b81c448f09
Autor:
Taraneh Sadat Zavvar, Anton Amadeus Hörmann, Maximilian Klingler, Dominik Summer, Christine Rangger, Laurence Desrues, Hélène Castel, Pierrick Gandolfo, Elisabeth von Guggenberg
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 278 (2023)
Different attempts have been made in the past two decades to develop radiolabeled peptide conjugates with enhanced pharmacokinetic properties in order to improve the application for tumor imaging and peptide receptor radionuclide therapy (PRRT), whic
Externí odkaz:
https://doaj.org/article/3a432039ee8f46c0a37d73acde50cea6
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1467 (2022)
In order to enable 18F- and 177Lu-labelling within the same molecule, we introduced a silicon-based fluoride acceptor (SiFA) into the hexa-D-glutamate chain of DOTA-PP-F11N. In addition, minigastrin analogues with a prolonged as well as γ-linked D-g
Externí odkaz:
https://doaj.org/article/2d1035715dfe4b689a613ea02639b385
Autor:
Anton Amadeus Hörmann, Elisabeth Plhak, Maximilian Klingler, Christine Rangger, Joachim Pfister, Gert Schwach, Herbert Kvaternik, Elisabeth von Guggenberg
Publikováno v:
Molecules, Vol 27, Iss 6, p 2034 (2022)
The new minigastrin analog DOTA-MGS8 targeting the cholecystokinin-2 receptor (CCK2R) used in this study displays the combination of two site-specific modifications within the C-terminal receptor binding sequence together with an additional N-termina
Externí odkaz:
https://doaj.org/article/9a29287298c147499a41e800a70a5f70