Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Mini P. Sajan"'
Autor:
Mini P. Sajan, Barbara C. Hansen, Mildred Acevedo‐Duncan, Mark S. Kindy, Denise R. Cooper, Robert V. Farese
Publikováno v:
MedComm, Vol 2, Iss 1, Pp 3-16 (2021)
Abstract Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increases in lipids that activate hepatic a
Externí odkaz:
https://doaj.org/article/ec1d5d225cae4de1b000248920a5fece
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 1, Pp 70-80 (2015)
Pathogenesis of insulin resistance in leptin-deficient ob/ob mice is obscure. In another form of diet-dependent obesity, high-fat-fed mice, hepatic insulin resistance involves ceramide-induced activation of atypical protein kinase C (aPKC), which sel
Externí odkaz:
https://doaj.org/article/dda2d6e8d0d34a14b1b39e6fa81aea0a
Publikováno v:
Journal of Clinical Medicine, Vol 3, Iss 3, Pp 724-740 (2014)
This review focuses on how insulin signals to metabolic processes in health, why this signaling is frequently deranged in Western/Westernized societies, how these derangements lead to, or abet development of, insulin-resistant states of obesity, the
Externí odkaz:
https://doaj.org/article/a5b1b8f0b3ff4fecaf96abaf367d2a79
Autor:
Mini P. Sajan, Mary L. Standaert, Sonali Nimal, Usha Varanasi, Tina Pastoor, Stephen Mastorides, Ursula Braun, Michael Leitges, Robert V. Farese
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 6, Pp 1133-1145 (2009)
Obesity is frequently associated with systemic insulin resistance, glucose intolerance, and hyperlipidemia. Impaired insulin action in muscle and paradoxical diet/insulin-dependent overproduction of hepatic lipids are important components of obesity,
Externí odkaz:
https://doaj.org/article/cbd0e4503c614e25a7cc9521df278c5a
Autor:
Mini P, Sajan, Michael, Leitges, Colin, Park, David M, Diamond, Jin, Wu, Barbara C, Hansen, Mildred A, Duncan, Christopher A, Apostolatos, Andre H, Apostolatos, Mark, Kindy, Robert V, Farese
Publikováno v:
Current Alzheimer Research. 18:941-955
Βackground: β-Amyloid precursor protein-cleaving enzyme-1 (BACE1) initiates the production of Aβ-peptides that form Aβ-plaque in Alzheimer’s disease. Methods: Reportedly, acute insulin treatment in normal mice, and hyperinsulinemia in high-fat-
Autor:
Barbara C. Hansen, Robert V. Farese, Denise R. Cooper, Mildred Acevedo-Duncan, Mark S. Kindy, Mini P. Sajan
Publikováno v:
MedComm, Vol 2, Iss 1, Pp 3-16 (2021)
MedComm
MedComm
Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increases in lipids that activate hepatic atypical P
Publikováno v:
Alzheimer’s Disease: Drug Discovery ISBN: 9780645001709
Alzheimer’s disease (AD) is commonly, not always, associated with insulin-resistant, hyperinsulinemic, and obesity/type-2-diabetic (O/T2D) states. Partial deficiencies of brain insulin receptor (IR) indeed occur in both O/T2D-AD and human AD, but t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cadfc504bdd48b2a65801b92c50edc6
https://doi.org/10.36255/exonpublications.alzheimersdisease.2020.ch6
https://doi.org/10.36255/exonpublications.alzheimersdisease.2020.ch6
Autor:
Mini P. Sajan, Robert V. Farese
Alzheimer disease (AD) is thought to be caused by build-up of neurotoxic plaques containing Aβ peptides cleaved from amyloid precursor protein by β-secretase, compounded by increases in phospho-tau-containing neuronal “tangles.” Late-onset AD i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51c81b11e14d7d0d23c29ca54fa2b529
https://doi.org/10.1016/b978-0-12-815868-5.00013-x
https://doi.org/10.1016/b978-0-12-815868-5.00013-x
Autor:
Albert Aboseif, Morandi Alessandro, Carolina Alquézar, Rachel Anderson, Ellika Andolf, Tatiana Andreeva, Yasuhisa Ano, Yuko Araki, Eva M. Arroyo-Anlló, Tatsuhiro Ayabe, Mi Ae Bae, Kelly M. Bakulski, Vladimir J. Balcar, Vito Antonio Baldassarro, Petronilla Battista, Antonello Bellomo, Małgorzata Bednarska-Makaruk, Tammie L. Benzinger, Laura E. Berkowitz, L.C. Berumen, Andrea Bighinati, Amy Brodtmann, Josiane Budni, Laura Calzà, Rosa Capozzo, Paulo Caramelli, Barbara R. Cardoso, Jessie S. Carr, Javier Carrasco, J.W. Chang, Kyung Ja Chang, Lu Hua Chen, Sheung-Tak Cheng, Pozzi Christian, Leung Wing Chu, G. Cipriani, Benjamin J. Clark, Gemma Comes, Fabio Coppedè, Mar Cuadrado-Tejedor, Emanuela D'Acunto, Antonio Daniele, S. Danti, Antonella De Jaco, Rafael de la Torre, M. Di Fiorino, Grossi Eleonora, Kristina Endres, Anna Escrig, Robert V. Farese, Olaya Fernández-Gayol, Vitaly Fokin, Dan Frenkel, Wen Fu, Giovanna Galliciotti, G. García-Alcocer, Ana Garcia-Osta, Luciana Giardino, Roger Gil, Mercedes Giralt, Bellelli Giuseppe, Karina Braga Gomes, Manuel Gonçalves-Pereira, Miriam González-Gómez, Nandu Goswami, Elie Gottlieb, Antonio Greco, Dorothy M. Grillo, Natalie A. Grima, Chiara Griseta, Malena dos Santos Guilherme, Ryan E. Harvey, Manabu Hashimoto, Nathan Herrmann, Adriana Gisele Hertzog da Silva Leme, Emi Hibino, Juan Hidalgo, Mark Howard, Howard Hu, Sergey Illarioshkin, Nibaldo C. Inestrosa, Jack H. Jhamandas, Amber Khan, Maddalena La Montagna, Krista L. Lanctôt, Katarzyna Laskowska-Kaszub, Han-Kyu Lee, Lei Liu, Celina S. Liu, Alberto Llorente-Ovejero, Giancarlo Logroscino, Laura Lombardero, Stephanie Lozano, Madia Lozupone, Yasmina Manso, Iván Manuel, Raquel Marin, Ángeles Martín-Requero, Pamela V. Martino Adami, J. Mendiola-Precoma, Elena Miranda, Yachiyo Mitsuishi, Amalia Molinero, Laura Morelli, John C. Morris, Kelsey E. Murphy, Masaki Nakano, Siranjeevi Nagaraj, Yuval Nash, Masaki Nishimura, A. Nuti, Jade de Oliveira, Francesco Panza, Joshua J. Park, Y.S. Park, Sung Kyun Park, Matthew P. Pase, L. Picchi, Natalya Ponomareva, Matthew L. Poole, Victor R. Preedy, Ricardo Puertas-Avendaño, Henry Querfurth, David Quinto-Alemany, Luís Felipe José Ravic de Miranda, Rajkumar Rajendram, Onofrio Resta, Sven Reinhardt, A. Rodríguez-Cruz, Rafael Rodríguez-Puertas, Evgeny Rogaev, Michael Rosen, Mini P. Sajan, Paula Sanchis, Michele Sannia, Rodolfo Sardone, Makoto Sasaki, Diego Sepulveda-Falla, Davide Seripa, Omar Šerý, Daniel W. Sirkis, You-Qiang Song, Brenda Bin Su, Takuma Sugi, Paulina Villaseca, Adam P. Vogel, Douglas Gordon Walker, Hoau-Yan Wang, Kesheng Wang, Naoki Watanabe, David Weidman, Urszula Wojda, Benjamin K.P. Woo, Laura Xicota, Chun Xu, Dmitriy A. Yablonskiy, Fumio Yamashita, Hiroshi Yao, Jennifer S. Yokoyama, Fan Zhang, Juan M. Zolezzi, Katarzyn Marta Zoltowska
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9819dd54c387482eb5064a8816c26d6b
https://doi.org/10.1016/b978-0-12-815868-5.01002-1
https://doi.org/10.1016/b978-0-12-815868-5.01002-1
Autor:
Courtney Cleland, Mini P. Sajan, Fabienne Foufelle, Joshua Sajan, Robert V. Farese, Mackenzie C. Lee
Publikováno v:
Cellular Signalling. 43:62-70
Type 2 diabetes is characterized by insulin resistance, hyperinsulinemia and hepatic overproduction of glucose and lipids. Insulin increases lipogenic enzyme expression by activating Akt and aPKC which activate SREBP-1c; this pathway is hyperactivate