Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

Autor: Mini P. Sajan, Barbara C. Hansen, Mildred Acevedo‐Duncan, Mark S. Kindy, Denise R. Cooper, Robert V. Farese

Publikováno v: MedComm, Vol 2, Iss 1, Pp 3-16 (2021)

Abstract Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increases in lipids that activate hepatic a

Externí odkaz: https://doaj.org/article/ec1d5d225cae4de1b000248920a5fece

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity

Autor: Mini P. Sajan, Mary L. Standaert, Sonali Nimal, Usha Varanasi, Tina Pastoor, Stephen Mastorides, Ursula Braun, Michael Leitges, Robert V. Farese

Publikováno v: Journal of Lipid Research, Vol 50, Iss 6, Pp 1133-1145 (2009)

Obesity is frequently associated with systemic insulin resistance, glucose intolerance, and hyperlipidemia. Impaired insulin action in muscle and paradoxical diet/insulin-dependent overproduction of hepatic lipids are important components of obesity,

Externí odkaz: https://doaj.org/article/cbd0e4503c614e25a7cc9521df278c5a

Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

Autor: Barbara C. Hansen, Robert V. Farese, Denise R. Cooper, Mildred Acevedo-Duncan, Mark S. Kindy, Mini P. Sajan

Publikováno v: MedComm, Vol 2, Iss 1, Pp 3-16 (2021)
MedComm

Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increases in lipids that activate hepatic atypical P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80dcecbdba99fea257257ecbe68a8d1
https://doaj.org/article/ec1d5d225cae4de1b000248920a5fece

Atypical Protein Kinase C Hyperactivity in Insulin-Resistant and Insulin-Sensitive Forms of Alzheimer’s Disease: A Potential Therapeutic Target

Autor: Mark A. Kindy, Mini P. Sajan, Robert V. Farese

Publikováno v: Alzheimer’s Disease: Drug Discovery ISBN: 9780645001709

Alzheimer’s disease (AD) is commonly, not always, associated with insulin-resistant, hyperinsulinemic, and obesity/type-2-diabetic (O/T2D) states. Partial deficiencies of brain insulin receptor (IR) indeed occur in both O/T2D-AD and human AD, but t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cadfc504bdd48b2a65801b92c50edc6
https://doi.org/10.36255/exonpublications.alzheimersdisease.2020.ch6

Contributors

Autor: Albert Aboseif, Morandi Alessandro, Carolina Alquézar, Rachel Anderson, Ellika Andolf, Tatiana Andreeva, Yasuhisa Ano, Yuko Araki, Eva M. Arroyo-Anlló, Tatsuhiro Ayabe, Mi Ae Bae, Kelly M. Bakulski, Vladimir J. Balcar, Vito Antonio Baldassarro, Petronilla Battista, Antonello Bellomo, Małgorzata Bednarska-Makaruk, Tammie L. Benzinger, Laura E. Berkowitz, L.C. Berumen, Andrea Bighinati, Amy Brodtmann, Josiane Budni, Laura Calzà, Rosa Capozzo, Paulo Caramelli, Barbara R. Cardoso, Jessie S. Carr, Javier Carrasco, J.W. Chang, Kyung Ja Chang, Lu Hua Chen, Sheung-Tak Cheng, Pozzi Christian, Leung Wing Chu, G. Cipriani, Benjamin J. Clark, Gemma Comes, Fabio Coppedè, Mar Cuadrado-Tejedor, Emanuela D'Acunto, Antonio Daniele, S. Danti, Antonella De Jaco, Rafael de la Torre, M. Di Fiorino, Grossi Eleonora, Kristina Endres, Anna Escrig, Robert V. Farese, Olaya Fernández-Gayol, Vitaly Fokin, Dan Frenkel, Wen Fu, Giovanna Galliciotti, G. García-Alcocer, Ana Garcia-Osta, Luciana Giardino, Roger Gil, Mercedes Giralt, Bellelli Giuseppe, Karina Braga Gomes, Manuel Gonçalves-Pereira, Miriam González-Gómez, Nandu Goswami, Elie Gottlieb, Antonio Greco, Dorothy M. Grillo, Natalie A. Grima, Chiara Griseta, Malena dos Santos Guilherme, Ryan E. Harvey, Manabu Hashimoto, Nathan Herrmann, Adriana Gisele Hertzog da Silva Leme, Emi Hibino, Juan Hidalgo, Mark Howard, Howard Hu, Sergey Illarioshkin, Nibaldo C. Inestrosa, Jack H. Jhamandas, Amber Khan, Maddalena La Montagna, Krista L. Lanctôt, Katarzyna Laskowska-Kaszub, Han-Kyu Lee, Lei Liu, Celina S. Liu, Alberto Llorente-Ovejero, Giancarlo Logroscino, Laura Lombardero, Stephanie Lozano, Madia Lozupone, Yasmina Manso, Iván Manuel, Raquel Marin, Ángeles Martín-Requero, Pamela V. Martino Adami, J. Mendiola-Precoma, Elena Miranda, Yachiyo Mitsuishi, Amalia Molinero, Laura Morelli, John C. Morris, Kelsey E. Murphy, Masaki Nakano, Siranjeevi Nagaraj, Yuval Nash, Masaki Nishimura, A. Nuti, Jade de Oliveira, Francesco Panza, Joshua J. Park, Y.S. Park, Sung Kyun Park, Matthew P. Pase, L. Picchi, Natalya Ponomareva, Matthew L. Poole, Victor R. Preedy, Ricardo Puertas-Avendaño, Henry Querfurth, David Quinto-Alemany, Luís Felipe José Ravic de Miranda, Rajkumar Rajendram, Onofrio Resta, Sven Reinhardt, A. Rodríguez-Cruz, Rafael Rodríguez-Puertas, Evgeny Rogaev, Michael Rosen, Mini P. Sajan, Paula Sanchis, Michele Sannia, Rodolfo Sardone, Makoto Sasaki, Diego Sepulveda-Falla, Davide Seripa, Omar Šerý, Daniel W. Sirkis, You-Qiang Song, Brenda Bin Su, Takuma Sugi, Paulina Villaseca, Adam P. Vogel, Douglas Gordon Walker, Hoau-Yan Wang, Kesheng Wang, Naoki Watanabe, David Weidman, Urszula Wojda, Benjamin K.P. Woo, Laura Xicota, Chun Xu, Dmitriy A. Yablonskiy, Fumio Yamashita, Hiroshi Yao, Jennifer S. Yokoyama, Fan Zhang, Juan M. Zolezzi, Katarzyn Marta Zoltowska

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9819dd54c387482eb5064a8816c26d6b
https://doi.org/10.1016/b978-0-12-815868-5.01002-1