Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Minhong Tang"'
Publikováno v:
Investigational New Drugs.
TP53 (p53) and MYC are amongst the most frequently altered genes in cancer. Both are thus attractive targets for new anticancer therapies. Historically, however, both genes have proved challenging to target and currently there is no approved therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1a74b13771922ed4ec4d7c057d6d8b5
https://doi.org/10.1007/s10637-023-01368-1
https://doi.org/10.1007/s10637-023-01368-1
Publikováno v:
Cancers. 14(18)
Mutant p53 is one of the most attractive targets for new anti-cancer drugs. Although traditionally regarded as difficult to drug, several new strategies have recently become available for targeting the mutant protein. One of the most promising of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1c9512d469b240227b93b19b14f94a
https://pubmed.ncbi.nlm.nih.gov/36139658
https://pubmed.ncbi.nlm.nih.gov/36139658
Publikováno v:
Breast cancer research and treatment. 195(2)
Background MYC is one of the most frequently altered driver genes in triple-negative breast cancer (TNBC). The aim of this study was to evaluate targeting MYC for the treatment of TNBC. Methods The anti-proliferative and apoptosis-inducing effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fdccd53bf5c76967d96c5e7483ac94
https://pubmed.ncbi.nlm.nih.gov/35908121
https://pubmed.ncbi.nlm.nih.gov/35908121
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 1, p 262 (2019)
Volume 21
Issue 1
International Journal of Molecular Sciences, Vol 21, Iss 1, p 262 (2019)
Volume 21
Issue 1
Targeted delivery of potent inhibitor of cytokine/pain-mediator into inflammatory or pain-sensing cells is a promising avenue for treating chronic pain, a world-wide major healthcare burden. An unmet need exists for a specific and effective delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ede822e0c28f962654f1d7b72398d0b
http://europepmc.org/articles/PMC6981458
http://europepmc.org/articles/PMC6981458
Publikováno v:
Toxicon. 190:S74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47cda248496e71dedc8937d0520bac67
https://doi.org/10.1016/j.toxicon.2020.11.500
https://doi.org/10.1016/j.toxicon.2020.11.500
Publikováno v:
Scientific Reports
Botulinum neurotoxins (BoNTs) are the most toxic proteins known, due to inhibiting the neuronal release of acetylcholine and causing flaccid paralysis. Most BoNT serotypes target neurons by binding to synaptic vesicle proteins and gangliosides via a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8271b2202323b4b990a705c467703c7
https://doi.org/10.1038/srep44474
https://doi.org/10.1038/srep44474
Autor:
Abdul M. Rashid, Minhong Tang, Farzana Miah, Clare E. M. Stevenson, Stephen Bornemann, J. Elaine Barclay, Andrii Gorelik, David M. Lawson, Karl Syson
Publikováno v:
The Journal of Biological Chemistry
GlgE is a maltosyltransferase involved in α-glucan biosynthesis in bacteria that has been genetically validated as a target for tuberculosis therapies. Crystals of the Mycobacterium tuberculosis enzyme diffract at low resolution so most structural s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35977c55f84671239b56c46d0ec6d4df
https://ueaeprints.uea.ac.uk/id/eprint/77474/
https://ueaeprints.uea.ac.uk/id/eprint/77474/
Autor:
David M. Lawson, Dmitri I. Svergun, Anne Tuukkanen, Minhong Tang, Karl Syson, Clare E. M. Stevenson, Stephen Bornemann, Stephen G. Withers, Abdul M. Rashid, Gerhard Saalbach
Publikováno v:
Biochemistry
Biochemistry 53(15), 2494-2504 (2014). doi:10.1021/bi500183c
Biochemistry 53(15), 2494-2504 (2014). doi:10.1021/bi500183c
GlgE (EC 2.4.99.16) is an α-maltose 1-phosphate:(1→4)-α-d-glucan 4-α-d-maltosyltransferase of the CAZy glycoside hydrolase 13_3 family. It is the defining enzyme of a bacterial α-glucan biosynthetic pathway and is a genetically validated anti-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f7cf613d7643fdf037f5c0195b91d6
https://pubmed.ncbi.nlm.nih.gov/24689960
https://pubmed.ncbi.nlm.nih.gov/24689960
Autor:
Syson, Karl1, Stevenson, Clare E. M.1, Miah, Farzana1, Barclay, J. Elaine1, Minhong Tang1, Gorelik, Andrii1, Rashid, Abdul M.1, Lawson, David M.1, Bornemann, Stephen1 stephen.bornemann@jic.ac.uk
Publikováno v:
Journal of Biological Chemistry. 10/7/2016, Vol. 291 Issue 41, p21531-21540. 10p. 1 Black and White Photograph, 8 Diagrams, 3 Charts.