Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia

Autor: Asarnow, Daniel, Wang, Bei, Lee, Wen-Hsin, Hu, Yuanyu, Huang, Ching-Wen, Faust, Bryan, Ng, Patricia Miang Lon, Ngoh, Eve Zi Xian, Bohn, Markus, Bulkley, David, Pizzorno, Andrés, Ary, Beatrice, Tan, Hwee Ching, Lee, Chia Yin, Minhat, Rabiatul Adawiyah, Terrier, Olivier, Soh, Mun Kuen, Teo, Frannie Jiuyi, Yeap, Yvonne Yee Chin, Seah, Shirley Gek Kheng, Chan, Conrad En Zuo, Connelly, Emily, Young, Nicholas J., Maurer-Stroh, Sebastian, Renia, Laurent, Hanson, Brendon John, Rosa-Calatrava, Manuel, Manglik, Aashish, Cheng, Yifan, Craik, Charles S., Wang, Cheng-I

Publikováno v: In Cell 10 June 2021 184(12):3192-3204

Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization.

Autor: Wang B; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore., Asarnow D; Department of Biochemistry and Biophysics, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA., Lee WH; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore., Huang CW; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore., Faust B; Department of Biochemistry and Biophysics, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA., Ng PML; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore., Ngoh EZX; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore., Bohn M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, CA, USA., Bulkley D; Department of Biochemistry and Biophysics, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA., Pizzorno A; Virologie et Pathologie Humaine - VirPath team, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France., Tan HC; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore., Lee CY; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore., Minhat RA; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore., Terrier O; Virologie et Pathologie Humaine - VirPath team, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France., Soh MK; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore., Teo FJ; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore., Yeap YYC; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore., Hu Y; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore., Seah SGK; Biological Defence Program, DSO National Laboratories, 27 Medical Drive, Singapore 117510, Singapore., Maurer-Stroh S; Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore., Renia L; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Hanson BJ; Biological Defence Program, DSO National Laboratories, 27 Medical Drive, Singapore 117510, Singapore., Rosa-Calatrava M; Virologie et Pathologie Humaine - VirPath team, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.; VirNext, Faculté de Médecine RTH Laennec, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France., Manglik A; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, CA, USA.; Department of Anesthesia and Perioperative Care, UCSF, San Francisco, CA, USA., Cheng Y; Department of Biochemistry and Biophysics, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Howard Hughes Medical Institute, UCSF, San Francisco, CA, USA., Craik CS; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, CA, USA., Wang CI; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Jul 15. Date of Electronic Publication: 2020 Jul 15.