Výsledky vyhledávání

Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts

Autor: Elizabeth A. Ottinger, Minh-Ha Do, Marc Singleton, Bradley Class, Kirill Gorshkov, Ethan G. Fisher, Nicola Longo, Wei Zheng, Wenwei Huang, Xin Xu, Wei Sun, Amy Wang, Natasha Thorne, Marta Frigeni

Publikováno v: Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Pharmacology Research & Perspectives

Creatine transporter deficiency (CTD) is a metabolic disorder resulting in cognitive, motor, and behavioral deficits. Cyclocreatine (cCr), a creatine analog, has been explored as a therapeutic strategy for the treatment of CTD. We developed a rapid,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f7e7ac2f9d94eef29e9ecbc7a5091e
https://doi.org/10.1002/prp2.525

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Polyribosome and ribonucleoprotein complex redistribution of mRNA induced by GnRH involves both EIF2AK3 and MAPK signaling

Autor: Hiral Dave, Mark A. Lawson, Minh-Ha Do, Rachel E. Intriago, Feng He, Uriah A. Astorga, Tae-Shin Kim, Sonia Jain

Publikováno v: Molecular and cellular endocrinology. 382(1)

The neuropeptide gonadotropin-releasing hormone stimulates synthesis and secretion of the glycoprotein gonadotropic hormones and activates the unfolded protein response, which causes a transient reduction of endoplasmic reticulum-associated mRNA tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2757d497d2f1021ec4345f0e4f61a0
https://pubmed.ncbi.nlm.nih.gov/24161835

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Akademický článek

Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia.

Autor: Kanaji, Taisuke, My-Nuong Vo, Kanaji, Sachiko, Zarpellon, Alessandro, Shapiro, Ryan, Yosuke Morodomi, Akinori Yuzuriha, Koji Eto, Belani, Rajesh, Minh-Ha Do, Xiang-Lei Yang, Ruggeri, Zaverio M., Schimmel, Paul

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 8/28/2018, Vol. 115 Issue 35, pE8228-E8235, 8p

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Akademický článek

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Extracellular Tyrosyl-tRNA Synthetase Is a Potent Stimulator of Thrombocytopoiesis

Autor: Paul Schimmel, My-Nuong Vo, Sachiko Kanaji, Xiang-Lei Yang, Taisuke Kanaji, Zaverio M. Ruggeri, Alessandro Zarpellon, Minh-Ha Do, Ryan Shapiro, Rajesh Belani

Publikováno v: Blood. 128:1476-1476

Aminoacyl-tRNA synthetases (aaRSs) are enzymes with a key role in the first step of protein synthesis by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08dfdfaaabd68f08ea910a8b6d6e433f
https://doi.org/10.1182/blood.v128.22.1476.1476

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Orthogonal use of a human tRNA synthetase active site to achieve multi-functionality

Autor: Melanie Hanan, Leslie A. Nangle, Minh-Ha Do, Chulho Park, Xiang-Lei Yang, Quansheng Zhou, Eva R. Armour, Rajesh Belani, William B. Kiosses, Paul Schimmel, Xiaoling Xu, Min Guo, Mili Kapoor

Protein multi-functionality is an emerging explanation for the complexity of higher organisms. In this regard, while aminoacyl tRNA synthetases catalyze amino acid activation for protein synthesis, some also act in pathways for inflammation, angiogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473a565c2668a8c05fe0b060d46d32a5
https://europepmc.org/articles/PMC3042952/

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Insulin Augments Gonadotropin-Releasing Hormone Induction of Translation in LβT2 Cells

Autor: Hyunjin Song, Brian D. Cherrington, Amy M. Navratil, Mark A. Lawson, Janine M. Low, Minh-Ha Do, Jeniffer B. Hernandez, Sharon J. Santos

The integrated signaling of insulin and gonadotropin-releasing hormone in the pituitary gonadotropes may have a profound bearing on reproductive function, although the cross-receptor signaling mechanisms are unclear. We demonstrate that the insulin r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f18eb49e127d49a0ef54b386003347
https://europepmc.org/articles/PMC2739255/

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GNRH induces the unfolded protein response in the LbetaT2 pituitary gonadotrope cell line

Autor: Mark A. Lawson, Sharon J. Santos, Minh-Ha Do

Publikováno v: Molecular endocrinology (Baltimore, Md.). 23(1)

The neuropeptide GNRH 1 stimulates the secretion of the reproductive hormone LH in pituitary gonadotropes. Other secretory cell types depend on the unfolded protein response (UPR) pathway to regulate protein synthesis and protect against endoplasmic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc3162eced6d21de249e6a47f7a31ad
https://pubmed.ncbi.nlm.nih.gov/18974261

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Novel Protein Agonist of Thrombopoiesis Acts Via a Physiocrine Pathway Distinct From That of Thrombopoietin

Autor: Melissa Ashlock, Alain Philippe Vasserot, My-Nuong Vo, Lori Kunkel, Minh-Ha Do, Rajesh Belani, Kyle P. Chiang, Chulho Park, Quansheng Zhou, John D. Mendlein, Chi-Fang Wu, Xiang-Lei Yang, Wei Zhang, Jeffry D. Watkins

Publikováno v: Blood. 118:2376-2376

Abstract 2376 Thrombopoietin (TPO) is recognized as the main regulator of platelet production, yet its genetic ablation in mice does not completely obliterate thrombopoiesis, suggesting that alternate pathways could lead to platelet formation. We rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76d9b01d4c944f18b1c509d4dbfa4e85
https://doi.org/10.1182/blood.v118.21.2376.2376

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