Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Minh V. Huynh"'
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Functional and biological heterogeneity of KRAS
Autor: Minh V, Huynh, G Aaron, Hobbs, Antje, Schaefer, Mariaelena, Pierobon, Leiah M, Carey, J Nathaniel, Diehl, Jonathan M, DeLiberty, Ryan D, Thurman, Adelaide R, Cooke, Craig M, Goodwin, Joshua H, Cook, Lin, Lin, Andrew M, Waters, Naim U, Rashid, Emanuel F, Petricoin, Sharon L, Campbell, Kevin M, Haigis, Diane M, Simeone, Costas A, Lyssiotis, Adrienne D, Cox, Channing J, Der
Publikováno v: Sci Signal
Although oncogenic driver mutations in RAS occur in 20% of cancers, heterogeneity in the biologic outputs of different RAS mutants has hampered efforts to develop effective treatments for RAS-mutated cancers. In this issue of Science Signaling, Huynh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::902a36258802379ec4087c4e0daa0e25
https://pubmed.ncbi.nlm.nih.gov/35944067
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Functional and biological heterogeneity of KRAS Q61 mutations
Autor: Minh V. Huynh, G. Aaron Hobbs, Antje Schaefer, Mariaelena Pierobon, Leiah M. Carey, J. Nathaniel Diehl, Jonathan M. DeLiberty, Ryan D. Thurman, Adelaide R. Cooke, Craig M. Goodwin, Joshua H. Cook, Lin Lin, Andrew M. Waters, Naim U. Rashid, Emanuel F. Petricoin, Sharon L. Campbell, Kevin M. Haigis, Diane M. Simeone, Costas A. Lyssiotis, Adrienne D. Cox, Channing J. Der
Publikováno v: Science Signaling. 15
Missense mutations at the three hotspots in the guanosine triphosphatase (GTPase) RAS—Gly 12 , Gly 13 , and Gln 61 (commonly known as G12, G13, and Q61, respectively)—occur differentially among the three RAS isoforms. Q61 mutations in KRAS are in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81a3b4c161cea4d936e027bb855de402
https://doi.org/10.1126/scisignal.abn2694
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5
Kinetic and Redox Characterization of KRAS G12C Inhibition
Autor: Minh V. Huynh, Derek Parsonage, Tom E. Forshaw, Venkata R. Chirasani, G. Aaron Hobbs, Hanzhi Wu, Jingyun Lee, Cristina M. Furdui, Leslie B. Poole, Sharon L. Campbell
The development of mutant-selective inhibitors for the KRASG12C allele has generated considerable excitement. These KRASG12C inhibitors covalently engage the mutant C12 thiol located within the phosphoryl binding loop of RAS, locking the KRASG12C pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d179fea6ae88ced5795a169e74ee2824
https://doi.org/10.1101/2022.04.03.486828
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7
A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation
Autor: Guowei Yin, Nora Kuhlmann, Channing J. Der, Rachel Bagni, Samantha K. Kistler, Sharon L. Campbell, Leslie Garvey, Minh V. Huynh, Samuel D. George, Michael Lammers
Publikováno v: Journal of Biological Chemistry. 292:4446-4456
The KRAS GTPase plays a critical role in the control of cellular growth. The activity of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), and also post-translational modification. Lysine 104 in KRAS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85a7594a3253e143048cd906a310d7e
https://doi.org/10.1074/jbc.m116.762435
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8
Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma
Autor: Christin E. Burd, Michael J. Miley, Wenjin Liu, Bruce C. Baguley, David B. Darr, Norman E. Sharpless, Meriam A. Waqas, Brit L. Martin, Kailing Fu, William R. Jeck, Kelly S. Clark, George P. Souroullas, Daniel C. Zedek, Minh V. Huynh, Sharon L. Campbell, James E. Gillahan
Publikováno v: Cancer Discovery. 4:1418-1429
NRAS mutation at codons 12, 13, or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an NrasQ61R knock-in allele to similarly designed KrasG12D
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c17ab817920437a7f486a5bdd9c404
https://doi.org/10.1158/2159-8290.cd-14-0729
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9
Abstract IA18: Activation of RAS by post-translational modification: Ubiquitination and thiol oxidation
Autor: Atsuo T. Sasaki, Aaron Hobbs, Sharon L. Campbell, Rachael Baker, Henrik G. Dohlman, Minh V. Huynh
Publikováno v: Molecular Cancer Research. 12:IA18-IA18
Ras proteins are critical regulators of multiple pathways involved in cellular growth control. Activating mutations in Ras genes are found in 33% of human cancers, with Ras well recognized as the most commonly mutated oncogene in human cancer. Mutati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::186dbb26c59943bf955ddd6ec512c895
https://doi.org/10.1158/1557-3125.rasonc14-ia18
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