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In Vitro Characterization of the Interaction between HIV-1 Gag and Human Lysyl-tRNA Synthetase

Autor: Minh K Hong, Robert Kennedy, Karin Musier-Forsyth, Siddhartha A. K. Datta, Brandie J. Kovaleski, Lawrence Kleiman, Alan Rein

Publikováno v: Journal of Biological Chemistry. 281:19449-19456

Human immunodeficiency virus type 1 (HIV-1) viral assembly is mediated by multiple protein-protein and protein-nucleic acid interactions. Human tRNALys3 is used as the primer for HIV reverse transcription, and HIV Gag and GagPol are required for pack

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c73576f2252647c4bfbd84ee0994b2
https://doi.org/10.1074/jbc.m601189200

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Efficient aminoacylation of tRNA(Lys,3) by human lysyl-tRNA synthetase is dependent on covalent continuity between the acceptor stem and the anticodon domain

Autor: Karin Musier-Forsyth, Minh K Hong, Timothy Stello

Publikováno v: Nucleic Acids Research. 27:4823-4829

In this work, we probe the role of the anticodon in tRNA recognition by human lysyl-tRNA synthetase (hLysRS). Large decreases in aminoacylation efficiency are observed upon mutagenesis of anticodon positions U35 and U36 of human tRNA(Lys,3). A minihe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4cafb491278b92b2785a073bc8ab0d0
https://doi.org/10.1093/nar/27.24.4823

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Nucleic acid conformational changes essential for HIV-1 nucleocapsid protein-mediated inhibition of self-priming in minus-strand transfer

Autor: Paul F. Barbara, Donald B. O'Connor, Elizabeth J. Harbron, Jianhui Guo, Minh K Hong, Karin Musier-Forsyth, Judith G. Levin

Publikováno v: Journal of molecular biology. 325(1)

Reverse transcription of the HIV-1 genome is a complex multi-step process. HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone protein that has been shown to greatly facilitate the nucleic acid rearrangements that precede the minus-strand tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f0c36c7e3f88b712ab25e49406677c
https://pubmed.ncbi.nlm.nih.gov/12473448

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Differentiation of Human Natural Killer Cells From Pluripotent Stem Cells In a Feeder Free System Amenable to Clinical Translation

Autor: Dan S. Kaufman, Zhenya Ni, Melinda K. Hexum, David A. Knorr, Patrick J. Walsh, Amanda Gussiaas, Minh K Hong

Publikováno v: Blood. 116:107-107

Abstract 107 Human natural killer (NK) cells are an attractive source of lymphocytes for adoptive immunotherapy. Although our understanding of natural killer cell biology continually grows, translating these concepts to the clinic has fallen behind.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d817ba58030ee707098ecd84f0a3525
https://doi.org/10.1182/blood.v116.21.107.107

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