Not flavone-8-acetic acid (FAA) but its murine metabolite 6-OH-FAA exhibits remarkable antivascular activities in vitro

Autor: Daniel Dauzonne, Minh Hien Pham, Guy G. Chabot

Publikováno v: Anti-Cancer Drugs
Anti-Cancer Drugs, Lippincott, Williams & Wilkins, 2016, 27 (5), pp.398-406. ⟨10.1097/CAD.0000000000000341⟩

International audience; Flavone-8-acetic acid (FAA) has been proved to be a potent vascular-disrupting agent in mice. Unfortunately, FAA did not produce any anticancer activity in clinical trials. Previously, we had reported that FAA is metabolized b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac22fac837731e4fc54b95c068156277
https://doi.org/10.1097/cad.0000000000000341

Characterization of monohydroxylated derivatives of the anticancer agent flavone-8-acetic acid by liquid chromatography with on-line UV and mass spectrometry

Autor: Nicolas Auzeil, Daniel Scherman, Minh Hien Pham, Daniel Dauzonne, Marie-Claude Menet, Anne Regazzetti, Guy G. Chabot, Annabelle Dugay

Publikováno v: Rapid Communications in Mass Spectrometry. 21:3373-3386

The experimental anticancer agent flavone-8-acetic acid (FAA) is metabolized into several monohydroxylated derivatives using mouse microsomes. Because these metabolites could be involved in the biological effects of FAA, the aim of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b608c73fc7afd3f01a36c3a8a4d1657e
https://doi.org/10.1002/rcm.3226

Peritoneoatrial Shunting for Intractable Chylous Ascites Complicating Thoracic Duct Ligation

Autor: Jérôme Jouan, Minh Hien Pham, Françoise Le Pimpec-Barthes, Jean-Noël Fabiani, Alain Bel, Marc Riquet

Publikováno v: The Annals of Thoracic Surgery. 87:1601-1603

Thoracic duct ligation for chylothorax is considered a safe and efficient procedure. However, we observed two cases that were complicated by intractable chylous ascites. Refractory chylous ascites are usually cured by surgical peritoneovenous shuntin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c397883f1bbf99d7121c619249c9f4
https://doi.org/10.1016/j.athoracsur.2008.09.029

Flavonoids in Cancer Prevention and Therapy: Chemistry, Pharmacology, Mechanisms of Action, and Perspectives for Cancer Drug Discovery

Autor: Daniel Dauzonne, Yasmine S. Touil, Minh Hien Pham, Guy G. Chabot

Publikováno v: Alternative and Complementary Therapies for Cancer ISBN: 9781441900197

Among the numerous products available from plants, the flavonoid superfamily plays a central role by its large number of molecules (over 6000) and also by the role these products occupy in the normal physiology of plants. Flavonoids are secondary pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab0fa3c261379beab31174eaa0d0a1cb
https://doi.org/10.1007/978-1-4419-0020-3_23

Serotonin Transporter Inhibitors Protect against Hypoxic Pulmonary Hypertension

Autor: Minh Hien Pham, Anne Nosjean, Bernadette Raffestin, Serge Adnot, Michel Hamon, Saadia Eddahibi, Elisabeth Marcos

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2003, 168 (4), pp.487-493. ⟨10.1164/rccm.200210-1212OC⟩
American Journal of Respiratory and Critical Care Medicine, 2003, 168 (4), pp.487-493. ⟨10.1164/rccm.200210-1212OC⟩

International audience; Pulmonary hypertension (PH) results from constriction and remodeling of pulmonary vessels. Serotonin contributes to both phenomena through different signaling pathways. The mitogenic effect of serotonin on pulmonary vascular s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd9f394d26693b767cf3b27f2c02d5d
https://hal.archives-ouvertes.fr/hal-03300325