Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Minh‐Ha T. Do"'
Autor:
Kirill Gorshkov, Amy Q. Wang, Wei Sun, Ethan Fisher, Marta Frigeni, Marc Singleton, Natasha Thorne, Bradley Class, Wenwei Huang, Nicola Longo, Minh‐Ha T. Do, Elizabeth A. Ottinger, Xin Xu, Wei Zheng
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Creatine transporter deficiency (CTD) is a metabolic disorder resulting in cognitive, motor, and behavioral deficits. Cyclocreatine (cCr), a creatine analog, has been explored as a therapeutic strategy for the treatment of CTD. We developed
Externí odkaz:
https://doaj.org/article/5eae92316c67492782ecbd46078cdb8d
Publikováno v:
Journal of the Endocrine Society. 5
Context We hypothesize, based on the degree of residual hypothalamic-pituitary function, that some, but not all, children with growth hormone deficiency (GHD) may have beneficial growth responses to the orally administered growth hormone (GH) secreta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0e20c0d5a44ff48d9353b3ef8b77caf
https://doi.org/10.1210/jendso/bvab030
https://doi.org/10.1210/jendso/bvab030
Autor:
Michael O. Thorner, Haiying Chen, John C. McKew, George M Bright, Minh-Ha T Do, Werner F. Blum
Publikováno v:
Journal of the Endocrine Society
Context Recombinant human growth hormone (rhGH) is approved for treatment of pediatric growth hormone deficiency (GHD), with greatest growth responses observed in those with severe GHD. Orally administered GH secretagogues (GHS) may be useful treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a971f31eb9636c61e08152fb71bc36
https://pubmed.ncbi.nlm.nih.gov/34141995
https://pubmed.ncbi.nlm.nih.gov/34141995
Autor:
Tommaso Pizzorusso, Francesco Cacciante, John C. McKew, Elena Putignano, Giovanni Cioni, Mariangela Gennaro, Giulia Sagona, Elisa Cerri, Mark Butt, Laura Baroncelli, Raffaele Mazziotti, Roberta Battini, Leonardo Lupori, Maria Grazia Alessandrì, Minh-Ha T Do
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Creatine Transporter Deficiency (CTD) is an inborn error of metabolism presenting with intellectual disability, behavioral disturbances and epilepsy. There is currently no cure for this disorder. Here, we employed novel biomarkers for monitoring brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00da635b233a095f2d86b2f4ac2de59
https://doi.org/10.1038/s41598-020-75436-4
https://doi.org/10.1038/s41598-020-75436-4
Autor:
Jeffrey J. Wallery, Pramod S. Terse, Joseph Novak, John C. McKew, Seth Gibbs, Vijay P. Kale, Minh-Ha T Do
Publikováno v:
Toxicol Appl Pharmacol
Cyclocreatine (LUM-001) was evaluated for chronic toxicity (23 weeks) in beagle dogs to support clinical development in patients with creatine transporter deficiency (CTD) disorder. Deionized water (vehicle control) or cyclocreatine was administered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce2456b0a9cb6b622453ad36a4eceb1
https://doi.org/10.1016/j.taap.2021.115680
https://doi.org/10.1016/j.taap.2021.115680
Publikováno v:
Regulatory Toxicology and Pharmacology. 123:104939
In standard general toxicology studies in two species to support clinical development, cyclocreatine, a creatine analog for the treatment of creatine transporter deficiency, caused deaths, convulsions, and/or multi-organ pathology. The potential tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b578f1506571bc3f1e05f01ff09f9a56
https://doi.org/10.1016/j.yrtph.2021.104939
https://doi.org/10.1016/j.yrtph.2021.104939
Autor:
Seth Gibbs, Vijay P. Kale, Minh-Ha T Do, Jeffery Wallery, Mohammed Bourdi, Pramod S. Terse, Joseph Novak, John C. McKew
Publikováno v:
Regulatory Toxicology and Pharmacology. 117:104750
Cyclocreatine (LUM-001), a creatine analog, was evaluated for its nonclinical toxicity in Sprague Dawley (SD) rats. Deionized water as a vehicle control article or cyclocreatine was administered by oral gavage twice daily (approximately 12 ± 1 h apa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ed0cd689a934f37fd67eb36c5fb9a8
https://doi.org/10.1016/j.yrtph.2020.104750
https://doi.org/10.1016/j.yrtph.2020.104750