Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Mingzhou, Guo"'
Autor:
Ruhao Wu, Ge Zhang, Mingzhou Guo, Yue Li, Lu Qin, Tianci Jiang, Pengfei Li, Yu Wang, Ke Wang, Yize Liu, Zhiqiu He, Zhe Cheng
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)
Abstract Pulmonary arterial hypertension (PAH) is a progressive and rapidly fatal disease with an intricate etiology. Identifying biomarkers for early PAH lesions based on the exploration of subtle biological processes is significant for timely diagn
Externí odkaz:
https://doaj.org/article/9a39d49464f742fa95c4fea841bd7cff
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is the most malignant tumor. Zinc finger and SCAN domain-containing protein 23 (ZSCAN23) is a new member of the SCAN domain family. The expression regulation and biological function remain to be elucidated. In
Externí odkaz:
https://doaj.org/article/7b552a4608154954999ee6b3123ad9a2
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundThere were about 1,090,000 gastric cancer (GC) cases in 2020 in China. The incidence and mortality rates ranked the fifth and third among all kinds of cancers in China. Early diagnosis plays an important role in the treatment and prognosis
Externí odkaz:
https://doaj.org/article/03b12f4816114db1bed49e113a04bdda
Publikováno v:
Chinese Medical Journal, Vol 137, Iss 3, Pp 273-282 (2024)
Abstract. Background:. Asthma imposes a large healthcare burden in China and the United States (US). However, the trends of asthma mortality and the relative risk factors have not been comparatively analyzed between the countries. The aim of this stu
Externí odkaz:
https://doaj.org/article/8513cc3c92bd430bbb0cf26be811adc9
Autor:
Hongyu Yuan, Zitong Zhao, Jing Xu, Ruiping Zhang, Liying Ma, Jing Han, Weihong Zhao, Mingzhou Guo, Yongmei Song
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background Hypoxia is one of most typical features in the tumor microenvironment of solid tumor and an inducer of endoplasmic reticulum (ER) stress, and HIF-1α functions as a key transcription factor regulator to promote tumor angiogenesis
Externí odkaz:
https://doaj.org/article/912635a1eb7249c0a2e1a7638b711a77
Autor:
Mingzhou Guo, Mengzhe Zhang, Xiaopei Cao, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Jianping Zhao, Yongjian Xu, Xiansheng Liu, Xiaochen Li
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background Hypoxic pulmonary hypertension (HPH) is a chronic progressive advanced disorder pathologically characterized by pulmonary vascular remodeling. Notch4 as a cell surface receptor is critical for vascular development. However, little
Externí odkaz:
https://doaj.org/article/66bdb01cc6aa4a3cb166ec10da21e376
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Notch signaling is involved in cell fate determination and deregulated in human solid tumors. Hypoxia is an important feature in many solid tumors, which activates hypoxia-induced factors (HIFs) and their downstream targets to promote tumorigenesis a
Externí odkaz:
https://doaj.org/article/830dbe02a8da4a30b1e2a847cfba5756
Autor:
Xiaopei Cao, Xiaoyu Fang, Mingzhou Guo, Xiaochen Li, Yuanzhou He, Min Xie, Yongjian Xu, Xiansheng Liu
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Hypoxic pulmonary hypertension (PH) is a refractory pulmonary vascular remodeling disease, and the efficiency of current PH treatment strategies is unsatisfactory. Tribbles homolog 3 (TRB3), a member of the pseudokinase family, is
Externí odkaz:
https://doaj.org/article/cd5268d388f74d458e3317039598cf1f
Autor:
Shuye Lin, Hanli Xu, Mengdi Pang, Xiaomeng Zhou, Yuanming Pan, Lishu Zhang, Xin Guan, Xiaoyue Wang, Bonan Lin, Rongmeng Tian, Keqiang Chen, Xiaochen Zhang, Zijiang Yang, Fengmin Ji, Yingying Huang, Wu Wei, Wanghua Gong, Jianke Ren, Ji Ming Wang, Mingzhou Guo, Jiaqiang Huang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundHepatocellular carcinoma (HCC) is one of the most lethal human tumors with extensive intratumor heterogeneity (ITH). Serine protease 3 (PRSS3) is an indispensable member of the trypsin family and has been implicated in the pathogenesis of s
Externí odkaz:
https://doaj.org/article/3a0aaf074ab648fa893225acf5efb412
Autor:
Aiai Gao, Mingzhou Guo
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Over the past decades, it is recognized that loss of DNA damage repair (DDR) pathways is an early and frequent event in tumorigenesis, occurring in 40-50% of many cancer types. The basis of synthetic lethality in cancer therapy is DDR defici
Externí odkaz:
https://doaj.org/article/e3901afec3a9461abfa65fa897e17ad4