Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Mingyu Xia"'
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Colon adenocarcinoma (COAD) represents a significant health concern within the population. Advancing our understanding of COAD is imperative for early detection, enabling personalized treatment interventions, and facilitating the development
Externí odkaz:
https://doaj.org/article/ef80697416894c8294ecf2a504b49383
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract The function of proteins depends on their correct structure and proper dynamics. Understanding the dynamics of target proteins facilitates drug design and development. However, dynamic information is often hidden in the spatial structure of
Externí odkaz:
https://doaj.org/article/b939d80fb001497880fe0b01c1bf3d2d
Autor:
Jintong Zhou, Mingyu Xia, Zhenghui Huang, Hang Qiao, Guang Yang, Yunan Qian, Peifeng Li, Zhaolun Zhang, Xinai Gao, Lubin Jiang, Jing Wang, Wei Li, Pengfei Fang
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Aminoacyl-tRNA synthetases (aaRSs) play a central role in the translation of genetic code, serving as attractive drug targets. Within this family, the lysyl-tRNA synthetase (LysRS) constitutes a promising antimalarial target. ASP3026, an ana
Externí odkaz:
https://doaj.org/article/74cbcfff29fa40fc9e97ade5313b1537
Autor:
Yiyun Lou, Jiaoyao Ma, Yangnan Hu, Xiaoying Yao, Yaoqian Liu, Mingxuan Wu, Gaogan Jia, Yan Chen, Renjie Chai, Mingyu Xia, Wenyan Li
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract The physiological interactions between the peripheral and central auditory systems are crucial for auditory information transmission and perception, while reliable models for auditory neural circuits are currently lacking. To address this is
Externí odkaz:
https://doaj.org/article/14b5eceb7bc94fb2bc9fbe5259a7e7c4
Publikováno v:
Journal of Marine Science and Engineering, Vol 12, Iss 9, p 1592 (2024)
The influence of oblique currents in narrow and shallow channels causes the fluid flow around ships to become complex. To analyze the hydrodynamic characteristics of a ship in such channels, it is essential to examine the influence of oblique current
Externí odkaz:
https://doaj.org/article/dc5cff9fe2294d1faa953c7a7231f334
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Structures of E. coli threonyl-tRNA synthetase in complex with natural product obafluorin (OB) reveal that OB is a unique covalent inhibitor.
Externí odkaz:
https://doaj.org/article/55ae5078a05f471b8069e492fd5a00e5
Autor:
Mingyu Xia, Jiaoyao Ma, Mingxuan Wu, Luo Guo, Yan Chen, Geng-lin Li, Shan Sun, Renjie Chai, Huawei Li, Wenyan Li
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 319-336 (2023)
Summary: Functional cochlear hair cells (HCs) innervated by spiral ganglion neurons (SGNs) are essential for hearing, whereas robust models that recapitulate the peripheral auditory circuity are still lacking. Here, we developed cochlear organoids wi
Externí odkaz:
https://doaj.org/article/16a3a833ebe541f2b7af9bbf1f3af42a
Autor:
Yang Sui, Ji Li, Jiqiang Qu, Ting Fang, Hongyan Zhang, Jian Zhang, Zheran Wang, Mingyu Xia, Yinghui Dai, Dongkai Wang
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 17, Iss 4, Pp 583-595 (2022)
Cancer vaccine contributing to the success of the treatment and prevention of tumors has attracted a huge attention as a strategy for tumor immunotherapy in recent years. A major challenge of cancer vaccine is to target cytosols of dendritic cells (D
Externí odkaz:
https://doaj.org/article/f6be04fd4fbc476291a11afdd712f25b
Autor:
Peilu Song, Fan Zhao, Dahong Li, Jiqiang Qu, Miao Yao, Yuan Su, Hanxun Wang, Miaomiao Zhou, Yujie Wang, Yinli Gao, Feng Li, Dongmei Zhao, Fengjiao Zhang, Yu Rao, Mingyu Xia, Haitao Li, Jian Wang, Maosheng Cheng
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 6, Pp 2905-2922 (2022)
The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallography and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1H-indole derivat
Externí odkaz:
https://doaj.org/article/f8f315b4d41341e19ffcb1ea0a529a41
Autor:
Jing Cui, Jingcheng Zhou, Weiqing He, Juan Ye, Timothy Westlake, Rogelio Medina, Herui Wang, Bhushan L. Thakur, Juanjuan Liu, Mingyu Xia, Zhonggui He, Fred E. Indig, Aiguo Li, Yan Li, Robert J. Weil, Mirit I. Aladjem, Laiping Zhong, Mark R. Gilbert, Zhengping Zhuang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-15 (2022)
Abstract Background Compared to normal cells, cancer cells exhibit a higher level of oxidative stress, which primes key cellular and metabolic pathways and thereby increases their resilience under oxidative stress. This higher level of oxidative stre
Externí odkaz:
https://doaj.org/article/445271d602864e3ab3bd004faac35132