Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Mingyu Guan"'
Publikováno v:
Proceedings of the 5th ACM SIGMOD Joint International Workshop on Graph Data Management Experiences & Systems (GRADES) and Network Data Analytics (NDA).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd73217b7233cf114db5c7b432a2f588
https://doi.org/10.1145/3534540.3534691
https://doi.org/10.1145/3534540.3534691
Autor:
Qingqing Zhou, Yinpeng Zhang, Xin Li, Jingying Qiu, Qinghua Song, Mingyu Guan, Xiaoke Gu, Jing Chen
Publikováno v:
European Journal of Medicinal Chemistry. 180:62-71
Oxidative stress and inflammation are major causes of numerous life-threatening human diseases. In the present study, we synthesized a series of phenylacrylamide derivatives as novel anti-oxidant and anti-inflammatory agents. Biological evaluation sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbf14b7a178d9404f3e15d33c7cf309
https://doi.org/10.1016/j.ejmech.2019.07.020
https://doi.org/10.1016/j.ejmech.2019.07.020
Autor:
Jingying Qiu, Jing Chen, Lu Qian, Qingqing Zhou, Xin Li, Xiaoxing Yin, Mingyu Guan, Jiang Yanfei, Xiaoke Gu, Yinpeng Zhang
Publikováno v:
European Journal of Medicinal Chemistry. 162:59-69
Oxidative stress plays a significant role in the pathogenesis of various human diseases. In this study, a series of bifendate derivatives bearing acrylamide moiety were synthesized and evaluated as anti-oxidant agents. Biological evaluation indicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e2d1271411efd1d1419a4b0be517c6
https://doi.org/10.1016/j.ejmech.2018.11.003
https://doi.org/10.1016/j.ejmech.2018.11.003
Autor:
Mingyu Guan, Zhi Li, Jie Ouyang, Gangyong Li, Liang Chen, Minjie Zhou, Binhong He, Wenyuan Xu, Wei Wang, Zhaohui Hou
Publikováno v:
Materials Today Communications. 31:103652
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5900c33d4d8522d16e885e090d2d6dd6
https://doi.org/10.1016/j.mtcomm.2022.103652
https://doi.org/10.1016/j.mtcomm.2022.103652
Publikováno v:
Chemistrybiodiversity. 18(2)
P-Glycoprotein (P-gp) overexpression is considered to be the leading cause of multidrug resistance (MDR) and failure of chemotherapy for leukemia. In this study, seventeen thiosemicarbazone-containing compounds were prepared and evaluated as potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7a37a839097bd04b4b6cc5a05164a3
https://pubmed.ncbi.nlm.nih.gov/33314614
https://pubmed.ncbi.nlm.nih.gov/33314614
Publikováno v:
Organic Chemistry Frontiers. 4:2408-2411
Oxindole/isatin-N-acetamide derivatives are a class of important pharmacologically active compounds. Herein, we report a practical protocol for the synthesis of such derivatives based on palladium-catalyzed intramolecular amination. Various functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30eec8341d68ceb3f199e805da6bb023
https://doi.org/10.1039/c7qo00710h
https://doi.org/10.1039/c7qo00710h
Publikováno v:
Bioorganic & Medicinal Chemistry. 29:115892
As a continuation of our previous work, a series of new phenyl acrylamide derivatives (4Aa-g, 4Ba-t, 5 and 6a-c) were designed and synthesized as non-nucleoside anti-HBV agents. Among them, compound 4Bs could potently inhibit HBV DNA replication in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711773df1832e0e9a1cebe4b198ce3a4
https://doi.org/10.1016/j.bmc.2020.115892
https://doi.org/10.1016/j.bmc.2020.115892
Autor:
Nan Sun, Xiaoke Gu, Jingying Qiu, Yueting Zou, Jing Chen, Chunyu Jiang, Xin Li, Qingqing Zhou, Mingyu Guan, Qinghua Song
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127638
P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major obstacle to successful chemotherapy for leukemia. In this study, a series of thiosemicarbazone-containing compounds (4a-b, 7a-q) were synthesized. Biological evaluation showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e824a5d5e5a4fd29986f15bca6e59573
https://doi.org/10.1016/j.bmcl.2020.127638
https://doi.org/10.1016/j.bmcl.2020.127638
Autor:
Yueting Zou, Mingyu Guan, Xin Li, Yinpeng Zhang, Xiaoke Gu, Jingying Qiu, Yali Zhao, Wang Chen, Xuan Huang, Qingqing Zhou
Publikováno v:
European Journal of Medicinal Chemistry. 205:112581
As a continuation of earlier works, a series of novel quinazolinone derivatives (5a-s) were synthesized and evaluated for their in vitro anti-HBV and anti-hepatocellular carcinoma cell (HCC) activities. Among them, compounds 5j and 5k exhibited most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103ea41e97962f05c61d634be077bb1e
https://doi.org/10.1016/j.ejmech.2020.112581
https://doi.org/10.1016/j.ejmech.2020.112581
Publikováno v:
Organic Letters. 17:1802-1805
A simple and practical exo-oxime ether auxilixary for ortho-C-H functionalization of aromatic alcohols has been developed. Selective olefination of aromatic alcohols were first achieved via a six- or seven-membered exo-acetone oxime ether palladacycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca88c2a5e9723532e4247879ab8669f
https://doi.org/10.1021/acs.orglett.5b00594
https://doi.org/10.1021/acs.orglett.5b00594