Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mingyu Chung"'
Autor:
Marielle S. Köberlin, Yilin Fan, Chad Liu, Mingyu Chung, Antonio F. M. Pinto, Peter K. Jackson, Alan Saghatelian, Tobias Meyer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Lipid synthesis increases during the cell cycle to ensure sufficient membrane mass, but how insufficient synthesis restricts cell-cycle entry is not understood. Here, we identify a lipid checkpoint in G1 phase of the mammalian cell cycle by
Externí odkaz:
https://doaj.org/article/46284f4c6c074cc8a607922f662f2987
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Clinical CDK4/6 inhibitors are used and tested to treat a variety of cancer types. Here, the authors identify that these drugs work in two ways, a known catalytic role to inhibit kinase activity and a newly discovered noncatalytic role to displace CD
Externí odkaz:
https://doaj.org/article/6d14f142aabc4361a0362428e11c38f1
Autor:
Chad Liu, Yumi Konagaya, Mingyu Chung, Leighton H. Daigh, Yilin Fan, Hee Won Yang, Kenta Terai, Michiyuki Matsuda, Tobias Meyer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
How normal cells proliferate without CDK4 and CDK6, two cancer-driving kinases, remains unclear. Here, the authors show that without CDK4/6 activity, cells start the cell cycle with a different signaling order and commitment point, revealing unexpect
Externí odkaz:
https://doaj.org/article/4a2a815723b8428281f4154d5dbff8d9
Autor:
Hee Won Yang, Steven D Cappell, Ariel Jaimovich, Chad Liu, Mingyu Chung, Leighton H Daigh, Lindsey R Pack, Yilin Fan, Sergi Regot, Markus Covert, Tobias Meyer
Publikováno v:
eLife, Vol 9 (2020)
Mammalian cells typically start the cell-cycle entry program by activating cyclin-dependent protein kinase 4/6 (CDK4/6). CDK4/6 activity is clinically relevant as mutations, deletions, and amplifications that increase CDK4/6 activity contribute to th
Externí odkaz:
https://doaj.org/article/c8323a5823b049878d5ba96e3bf677b6
Autor:
Sara Gookin, Mingwei Min, Harsha Phadke, Mingyu Chung, Justin Moser, Iain Miller, Dylan Carter, Sabrina L Spencer
Publikováno v:
PLoS Biology, Vol 15, Iss 9, p e2003268 (2017)
The cell-cycle field has identified the core regulators that drive the cell cycle, but we do not have a clear map of the dynamics of these regulators during cell-cycle progression versus cell-cycle exit. Here we use single-cell time-lapse microscopy
Externí odkaz:
https://doaj.org/article/2dd7841c8d704303af2b8059aa29fc1c
Publikováno v:
Molecular cell. 83(1)
Human cells license tens of thousands of origins of replication in G1 and then must stop all licensing before DNA synthesis in S phase to prevent re-replication and genome instability that ensue when an origin is licensed on replicated DNA. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1feff1a51955938b7876758ca410e3ce
https://pubmed.ncbi.nlm.nih.gov/36608667
https://pubmed.ncbi.nlm.nih.gov/36608667
Autor:
Daniel I. Benjamin, Jamie O. Brett, Pieter Both, Joel S. Benjamin, Heather L. Ishak, Jengmin Kang, Soochi Kim, Mingyu Chung, Marina Arjona, Christopher W. Nutter, Jenna H. Tan, Ananya K. Krishnan, Hunter Dulay, Sharon M. Louie, Antoine de Morree, Daniel K. Nomura, Thomas A. Rando
Publikováno v:
Cell Metabolism. 35:472-486.e6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fea0fe8b5db3b6819fc5020f33f94c52
https://doi.org/10.1016/j.cmet.2023.02.001
https://doi.org/10.1016/j.cmet.2023.02.001
Autor:
Polly Huang, Thomas A. Rando, Albin Huang, Alexander Lieu, Michelle Mao, Qiang Gan, Mingyu Chung, Kevin Yu, Cristina Rodriguez-Mateo, Ling Liu, Gregory W. Charville, Sharon Yang
Publikováno v:
Proc Natl Acad Sci U S A
Skeletal muscle possesses remarkable regenerative ability because of the resident muscle stem cells (MuSCs). A prominent feature of quiescent MuSCs is a high content of heterochromatin. However, little is known about the mechanisms by which heterochr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b4dfe20f6a184ad7845330ff015139
https://doi.org/10.1073/pnas.2025281118
https://doi.org/10.1073/pnas.2025281118
Understanding the stability or binding affinity of protein complex members is important for understanding their regulation and roles in cells. While there are many biochemical methods to measure protein-protein interactions in vitro, these methods of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9580a421448bb638b27abd50e8e2c105
https://doi.org/10.21203/rs.3.pex-1479/v1
https://doi.org/10.21203/rs.3.pex-1479/v1
A fundamental concept in eukaryotic DNA replication is the temporal separation of G1 origin licensing from S phase origin firing. Re-replication and genome instability ensue if licensing occurs after DNA synthesis has started. In humans and other ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5624c4ef743c63da418ea61150731368
https://doi.org/10.1101/2021.07.06.451311
https://doi.org/10.1101/2021.07.06.451311