Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Mingxue Gu"'
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101453- (2022)
Summary: Intracellular vesicles such as lysosomes contain micromolar to millimolar concentrations of Zn2+, and disturbing lysosomal Zn2+ homeostasis via lysosomal Zn2+ release leads to mitochondria damage and consequent lytic cell death. Methods have
Externí odkaz:
https://doaj.org/article/fc17f7907b774cf69b022b9934292037
Autor:
Wanlu Du, Mingxue Gu, Meiqin Hu, Prateeksunder Pinchi, Wei Chen, Michael Ryan, Timothy Nold, Ahmed Bannaga, Haoxing Xu
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109848- (2021)
Summary: During tumor progression, lysosome function is often maladaptively upregulated to match the high energy demand required for cancer cell hyper-proliferation and invasion. Here, we report that mucolipin TRP channel 1 (TRPML1), a lysosomal Ca2+
Externí odkaz:
https://doaj.org/article/5c49e4e2b5084e68b170ba3c3d36f8c1
Publikováno v:
Protein & Cell, Vol 10, Iss 1, Pp 8-19 (2018)
Abstract Cells utilize calcium ions (Ca2+) to signal almost all aspects of cellular life, ranging from cell proliferation to cell death, in a spatially and temporally regulated manner. A key aspect of this regulation is the compartmentalization of Ca
Externí odkaz:
https://doaj.org/article/7038eec1136e44bebc3e708ecb53f0fa
Publikováno v:
Cell Reports, Vol 6, Iss 2, Pp 264-270 (2014)
MicroRNA alterations and axonopathy have been reported in patients with Alzheimer’s disease (AD) and in AD mouse models. We now report that miR-342-5p is upregulated in APP/PS1, PS1ΔE9, and PS1-M146V transgenic AD mice, and that this upregulation
Externí odkaz:
https://doaj.org/article/fe0dd2eb6ce847569bf0b624ef0043ce
The fruit flyDrosophila melanogasterhas provided important insights into how sensory information is transduced by Transient Receptor Potential (TRP) channels in the Peripheral Nervous System (PNS). However, TRP channels alone have not been able to co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2377faadb01cb415c774b3a47cad535
https://doi.org/10.1101/2023.03.07.531558
https://doi.org/10.1101/2023.03.07.531558
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783031315220
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3de24656c05726dc602e5b6f3e36cceb
https://doi.org/10.1007/164_2023_640
https://doi.org/10.1007/164_2023_640
Autor:
Timothy L. Cover, Zhuang Zhuang Zhao, Mingxue Gu, Raif S. Geha, Rajan Sah, Janet Chou, Richard I. Hume, Haoxing Xu, Yexin Yang, Ping Li, Nirakar Sahoo, Fernando Benavides, Shiyu Xiao, Xinghua Feng, Meiqin Hu, Ce Wang, Ying Yang
Publikováno v:
Proc Natl Acad Sci U S A
LRRC8 family proteins on the plasma membrane play a critical role in cellular osmoregulation by forming volume-regulated anion channels (VRACs) necessary to prevent necrotic cell death. We demonstrate that intracellular LRRC8 proteins acting within l
Autor:
Ahmed Bannaga, Mingxue Gu, Haoxing Xu, Wei Chen, Prateeksunder Pinchi, Timothy Nold, Meiqin Hu, Wanlu Du, Michael Ryan
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109848-(2021)
Cell reports
Cell reports
SUMMARY During tumor progression, lysosome function is often maladaptively upregulated to match the high energy demand required for cancer cell hyper-proliferation and invasion. Here, we report that mucolipin TRP channel 1 (TRPML1), a lysosomal Ca2+
Publikováno v:
Trends in Biochemical Sciences. 44:110-124
Lysosomes, the cell’s degradation center, are filled with acidic hydrolases. Lysosomes generate nutrient-sensitive signals to regulate the import of H(+), hydrolases, and endocytic and autophagic cargos, and the export of the degradation products (