Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Mingxi, Yao"'
Autor:
Chunping Mao, Fuan Deng, Wanning Zhu, Leiming Xie, Yijun Wang, Guoyin Li, Xingke Huang, Jiahui Wang, Yue Song, Ping Zeng, Zhenpeng He, Jingnan Guo, Yao Suo, Yujing Liu, Zhuo Chen, Mingxi Yao, Lu Zhang, Jun Shen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Immune checkpoint blockade (ICB) therapy has emerged as a new therapeutic paradigm for a variety of advanced cancers, but wide clinical application is hindered by low response rate. Here we use a peptide-based, biomimetic, self-assembly stra
Externí odkaz:
https://doaj.org/article/fd108998937049f7923b54c35d321f3d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/85ebd85de7af47d680b349d1dd00f77e
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundCongenital scoliosis and congenital anomalies of the kidney and urinary tract are distinct genetic disorders with differing clinical manifestations. Clinically, their coexistence is not rare, but the etiologies of these complex diseases rem
Externí odkaz:
https://doaj.org/article/edbee61633704e91b1d83df1eb2044a9
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
This study investigates differences in focal adhesion (FA) morphology and Talin cleavage levels between transformed and non-transformed cell lines. Utilizing fluorescently tagged wild-type Talin and Talin mutants with calpain cleavage site mutations,
Externí odkaz:
https://doaj.org/article/49e4f5d516a941148483dfc6f2f5cd28
Publikováno v:
APL Bioengineering, Vol 8, Iss 1, Pp 016114-016114-11 (2024)
α-Synuclein aggregation is a common trait in synucleinopathies, including Parkinson's disease. Being an unstructured protein, α-synuclein exists in several distinct conformational intermediates, contributing to both its function and pathogenesis. H
Externí odkaz:
https://doaj.org/article/bf6630149bac433a8918b1693654d2db
Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
Autor:
Jinyuan Vero Li, Chai-Ann Ng, Delfine Cheng, Zijing Zhou, Mingxi Yao, Yang Guo, Ze-Yan Yu, Yogambha Ramaswamy, Lining Arnold Ju, Philip W. Kuchel, Michael P. Feneley, Diane Fatkin, Charles D. Cox
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Li et al. investigates the role of N-linked glycosylation for the function of mechanosensitive ion channel Piezo1. They show that disease-linked loss of function mutations in Piezo1 that are trafficking defective lack N-linked glycosylation.
Externí odkaz:
https://doaj.org/article/838c42e3bd25417ab25bf8adfdc60922
Publikováno v:
ACS Sensors. 8:704-711
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b28144f6d80fceb7e2ff6035192ebb9
https://doi.org/10.1021/acssensors.2c02218
https://doi.org/10.1021/acssensors.2c02218
Autor:
Shimin Le, Xian Hu, Mingxi Yao, Hu Chen, Miao Yu, Xiaochun Xu, Naotaka Nakazawa, Felix M. Margadant, Michael P. Sheetz, Jie Yan
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2714-2723 (2017)
Summary: α-Actinins, a family of critical cytoskeletal actin-binding proteins that usually exist as anti-parallel dimers, play crucial roles in organizing the framework of the cytoskeleton through crosslinking the actin filaments, as well as in foca
Externí odkaz:
https://doaj.org/article/2bb50e12db49420da3892aa3fc69e6f2
Publikováno v:
Journal of the American Chemical Society. 144:16808-16818
The adhesions between Gram-positive bacteria and their hosts are exposed to varying magnitudes of tensile forces. Here, using an ultrastable magnetic tweezer-based single-molecule approach, we show the catch-bond kinetics of the prototypical adhesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0af5edae084f0c5e45cebe7c4d7a44
https://doi.org/10.1021/jacs.2c03961
https://doi.org/10.1021/jacs.2c03961
Autor:
Xuyao Liu, Yinan Wang, Mingxi Yao, Karen B. Baker, Benjamin Klapholz, Nicholas H. Brown, Benjamin T. Goult, Jie Yan
Vinculin is a mechanosensitive adapter protein that links the actin network to cell-extracellular matrix adhesions and cell-cell adhesions. It is perhaps the best characterized mechanoeffector, as it is recruited to sites of adhesion in response to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3afaf84ac996f2c4a2d6e06b4a5b1517
https://doi.org/10.1101/2023.05.25.542235
https://doi.org/10.1101/2023.05.25.542235
