Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mingu Gordon Park"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 309-318 (2023)
Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD). To inhibit ODC, α-difluoromethylornithine (DFMO), an irreversible ODC inhibitor, has
Externí odkaz:
https://doaj.org/article/8e991f6027494d0c8cedf211026e0c59
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-7 (2022)
Abstract Dopamine (DA) plays a vital role in brain physiology and pathology such as learning and memory, motor control, neurological diseases, and psychiatric diseases. In neurons, it has been well established that DA increases or decreases intracell
Externí odkaz:
https://doaj.org/article/1f470a1515434398998b8561d7d23308
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 2016-2024 (2021)
Many studies have focussed on modulating the activity of γ-aminobutyric acid transaminase (GABA-T), a GABA-catabolizing enzyme, for treating neurological diseases, such as epilepsy and drug addiction. Nevertheless, human GABA-T synthesis and purific
Externí odkaz:
https://doaj.org/article/891078d7d8384792b5b3a7b43d527e44
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4453 (2022)
Monoamine oxidase-B (MAOB) has been believed to mediate the degradation of monoamine neurotransmitters such as dopamine. However, this traditional belief has been challenged by demonstrating that it is not MAOB but MAOA which mediates dopamine degrad
Externí odkaz:
https://doaj.org/article/e1e4f7fff74f4ecaadb209f7485cf081
GABA synthesis in astrocytes mediates tonic inhibition to regulate patho-physiological processes in various brain regions. Monoamine oxidase B (MAO-B) has been known to be the most important metabolic enzyme for synthesizing GABA from the putrescine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a25e15138cfbdca3033dc01dc7822b52
https://doi.org/10.1101/2023.05.15.540086
https://doi.org/10.1101/2023.05.15.540086
Publikováno v:
Glia. 70:1799-1825
The organ of Corti, located in the cochlea in the inner ear, is one of the major sensory organs involved in hearing. The organ of Corti consists of hair cells, glia-like supporting cells, and the cochlear nerve, which work in harmony to receive sound
Autor:
Yulong Li, C. Justin Lee, Heejung Chun, Jinhyeong Joo, Hyun Soo Shim, Jaekwang Lee, Junsung Woo, Jinpyo Hong, Hyunji Kang, Hoon Ryu, Ye Eun Chun, Mingu Gordon Park, Sunpil Kim, Mijeong Park, Soo Jin Oh, Jiesi Feng, Moonsun Sa, Wuhyun Koh, Seung Eun Lee, Jeiwon Cho
Publikováno v:
Biological Psychiatry. 91:740-752
Background NMDAR hypofunction has been implicated in several psychiatric disorders with an impairment of cognitive flexibility. However, the molecular mechanism of how NMDAR hypofunction with decreased NMDAR tone causes the impairment of cognitive fl
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 38(1)
Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer's disease (AD). To inhibit ODC, α-difluoromethylornithine (DFMO), an irreversible ODC inhibitor, has b
Autor:
Yeon Ha Ju, Ae Nim Pae, Minwoo Wendy Jang, Lizaveta Gotina, Tai Young Kim, Seungtaek Kim, Young-Ho Jang, C. Justin Lee, Sangeun Jeon, Mingu Gordon Park, Woojin Won, Sunpil Kim, Sunkyu Han, Joungha Won
Publikováno v:
Experimental & Molecular Medicine
An ongoing pandemic of coronavirus disease 2019 (COVID-19) is now the greatest threat to global public health. Herbal medicines and their derived natural products have drawn much attention in the treatment of COVID-19, but the detailed mechanisms by
Autor:
Moonsun Sa, Jung Moo Lee, Mingu Gordon Park, Jiwoon Lim, Jong Min Joseph Kim, Wuhyun Koh, Bo-Eun Yoon, C. Justin Lee
Publikováno v:
Experimental neurobiology. 31(3)
The principal inhibitory transmitter, γ-aminobutyric acid (GABA), is critical for maintaining hypothalamic homeostasis and released from neurons phasically, as well as from astrocytes tonically. Although astrocytes in the arcuate nucleus (ARC) of th