Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Mingtian, Deng"'
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 4, Pp 3219-3237 (2023)
KDM5B is essential for early embryo development, which is under the control of maternal factors in oocytes. Granulosa cells (GCs) play a critical role during oocyte mature. However, the role of KDM5B in GCs remains to be elucidated. In the current st
Externí odkaz:
https://doaj.org/article/4075cbc49284477bbb82d65d20e18a5f
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Background Extracellular-signal-regulated kinase (ERK) direct cell fate determination during the early development. The intricate interaction between the deposition of H3K9me2, de novo 5mC, and its oxides affects the remodeling of zygotic ep
Externí odkaz:
https://doaj.org/article/fc23c5fd72584b0caf6da86c4045ea19
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Background In mammals, maternal gene products decay and zygotic genome activation (ZGA) during maternal to zygotic transition (MZT) is critical for the early embryogenesis. Y-box binding protein YBX1 plays vital roles in RNA stabilization an
Externí odkaz:
https://doaj.org/article/96341e8788954a2a82ef081b90b75621
FTO-mediated demethylation of GADD45B promotes myogenesis through the activation of p38 MAPK pathway
Autor:
Kaiping Deng, Yixuan Fan, Yaxu Liang, Yu Cai, Guomin Zhang, Mingtian Deng, Zhibo Wang, Jiawei Lu, Jianfei Shi, Feng Wang, Yanli Zhang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 34-48 (2021)
N6-methyladenosine (m6A) modification plays a critical role in mammalian development. However, the role of m6A in the skeletal muscle development remains largely unknown. Here, we report a global m6A modification pattern of goat skeletal muscle at tw
Externí odkaz:
https://doaj.org/article/009fabcdcba14ccd9785205c468e83b9
Publikováno v:
Biology, Vol 12, Iss 8, p 1095 (2023)
Oxidative damage to skin fibroblast cells is a causative factor in many skin diseases. Previous studies have reported that lysine-specific demethylase 4D (Kdm4d) is involved in DNA replication, but its role on antioxidant capacity remains unclear. In
Externí odkaz:
https://doaj.org/article/dac17086c0c248feafc8e95def17d59d
Autor:
Mingtian Deng, Yongjie Wan, Baobao Chen, Xiangpeng Dai, Zifei Liu, Yingnan Yang, Yu Cai, Yanli Zhang, Feng Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 54-66 (2021)
Long non-coding RNAs (lncRNAs) are involved in shaping chromosome conformation and regulation of preimplantation development. However, the role of lncRNA during somatic cell nuclear transfer (SCNT) reprogramming remains largely unknown. In the presen
Externí odkaz:
https://doaj.org/article/5239734ae03f4653841fe28db7ebe45a
Autor:
Mingtian Deng, BaoBao Chen, Zifei Liu, Yu Cai, Yongjie Wan, Guomin Zhang, Yixuan Fan, Yanli Zhang, Feng Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Maternal mRNA clearance is critical for the early embryo development, which is under the tight control of RNA N6-methyladenosine (m6A). However, little information is known regarding the maternal mRNA clearance and mechanisms behind it in farm animal
Externí odkaz:
https://doaj.org/article/46ce0fe7d2674120b5c4ca3ec878c98c
Autor:
Hua Yang, Mingtian Deng, Wenli Lv, Zongyou Wei, Yu Cai, Peiyong Cheng, Feng Wang, Yanli Zhang
Publikováno v:
Biology, Vol 11, Iss 2, p 289 (2022)
Male germ cells directly affect the reproduction of males; however, their accurate isolation and culture in vitro is extremely challenging, hindering the study of germ cell development and function. CRISPR/dcas9, as an efficient gene reprogramming sy
Externí odkaz:
https://doaj.org/article/2fdb0a5253974c97aaaf41114158a62f
Autor:
Xiaodan Li, Xiaolei Yao, Yongjin Bao, Kaiping Deng, Mingtian Deng, Fan Yang, Xuan Sun, Peihua You, Qingxian Cai, Feng Wang
Publikováno v:
Journal of Molecular Endocrinology. 70
The serine-threonine protein phosphatase 2A (PP2A) is a heterotrimeric enzyme complex that plays a vital role in regulating male reproductive activities. However, as an essential member of the PP2A family, the physiological functions of PP2A regulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9542313d07c677a58818babe8cf254f5
https://doi.org/10.1530/jme-22-0130
https://doi.org/10.1530/jme-22-0130
Publikováno v:
Biology, Vol 10, Iss 5, p 381 (2021)
It has been reported that hypoxic environments were more suitable for the in vitro development of mammalian embryos, but the underlying mechanisms were still unclear. In the present study, RNA-seq was performed to compare 8-cell-stage and blastocyst-
Externí odkaz:
https://doaj.org/article/e90349a004934b31ad785506eaba6901