Výsledky vyhledávání

In situ hydrogelation of forky peptides in prostate tissue for drug delivery

Autor: Wenying Zhong, Keming Xu, Suyun He, Mingtao Tao, Jing Liu

Publikováno v: Soft Matter. 15:4200-4207

Herein, we have designed and synthesized a novel forky peptide D3F3 that transforms into a hydrogel through crosslinking induced by ZIs stimuli. We have employed D3F3 as a suitable drug carrier that is conjugated with DOX. Since the concentration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4526f65c6ef8bc9a66134625cb4291d9
https://doi.org/10.1039/c9sm00196d

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The conjugates of forky peptides and nonsteroidal anti-inflammatory drugs (NSAID) self-assemble into supramolecular hydrogels for prostate cancer-specific drug delivery

Autor: Hongmei Li, Suyun He, Can Wu, Wenying Zhong, Jing Liu, Mingtao Tao, Leixia Mei, Keming Xu

Publikováno v: Journal of Materials Chemistry B. 7:469-476

Herein, we report supramolecular hydrogelators made of forky peptides and nonsteroidal anti-inflammatory drugs (NSAID). Two zinc ions (ZIs)-responsive short peptide dendrons (E3FID and E3FNP) modified by NSAID (indometacinand naproxen) were designed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c949934d2d19cbda30ee137ae498c3a
https://doi.org/10.1039/c8tb02307g

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In situ hydrogelation of bicalutamide-peptide conjugates at prostate tissue for smart drug release based on pH and enzymatic activity

Autor: Wenying Zhong, Can Wu, Suyun He, Leixia Mei, Mingtao Tao, Ziran Zhai, Keming Xu

Publikováno v: Nanoscale. 11:5030-5037

Tissue-specific self-assemblies of supramolecular hydrogels have attracted great interest in material design and biomedical applications, for in situ-formed hydrogels serve as an excellent local depot with tunable release of drug therapeutics. Here w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28577ac8e783efcc815cebaae0cf8e1
https://doi.org/10.1039/c8nr10528f

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Zinc-ion-mediated self-assembly of forky peptides for prostate cancer-specific drug delivery

Autor: Li Zhang, Mingtao Tao, Suyun He, Xuefang Luo, Keming Xu, Hongmei Li, Wenying Zhong

Publikováno v: Chemical Communications. 54:4673-4676

A novel forky peptide was designed and synthesized. The peptide self-assembled into supramolecular hydrogels triggered by zinc ions (ZIs). The hydrogels were designed for a drug delivery system (DDS), loaded with docetaxel and applied for the therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e4484e7f1e1c545229ce66ec762b82
https://doi.org/10.1039/c8cc00604k

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Overcoming multidrug resistance by a combination of chemotherapy and photothermal therapy mediated by carbon nanohorns

Autor: Junling Wang, Fengjuan Song, Wanqing Yue, Yajun Yin, Wenying Zhong, Ran Wang, Fangrong Zhang, Leixia Mei, Mingtao Tao

Publikováno v: Journal of Materials Chemistry B. 4:6043-6051

Multidrug resistance (MDR) is a major obstacle to cancer chemotherapy due to the overexpression of P-glycoprotein (P-gp). Herein, etoposide (ETO) was loaded onto oxidized carbon nanohorns (oxCNHs), which were modified by polyethylene glycol (PEG) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc1fc54abacfad8bf9915683fe3797d
https://doi.org/10.1039/c6tb01469k

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