Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mingkwan Greenwood"'
Autor:
Michael P. Greenwood, Mingkwan Greenwood, Soledad Bárez-López, Joe W. Hawkins, Katherine Short, Danijela Tatovic, David Murphy
Publikováno v:
Molecular Metabolism, Vol 70, Iss , Pp 101692- (2023)
Objectives: The excessive release of the antidiuretic hormone vasopressin is implicated in many diseases including cardiovascular disease, diabetes, obesity, and metabolic syndrome. Once thought to be elevated as a consequence of diseases, data now s
Externí odkaz:
https://doaj.org/article/a52dbdef36114e25bca621689850f73c
Autor:
Mingkwan Greenwood, Benjamin T. Gillard, Rizwan Farrukh, Alex Paterson, Ferdinand Althammer, Valery Grinevich, David Murphy, Michael P. Greenwood
Publikováno v:
Molecular Metabolism, Vol 63, Iss , Pp 101542- (2022)
Objectives: Dynamic changes to neuropeptide hormone synthesis and secretion by hypothalamic neuroendocrine cells is essential to ensure metabolic homeostasis. The specialised molecular mechanisms that allow neuroendocrine cells to synthesise and secr
Externí odkaz:
https://doaj.org/article/643d551f0e874f83a8efb9ddbc1bffd1
Autor:
Sarawut Khongwichit, Wannapa Sornjai, Kunlakanya Jitobaom, Mingkwan Greenwood, Michael P. Greenwood, Atitaya Hitakarun, Nitwara Wikan, David Murphy, Duncan R. Smith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Zika virus (ZIKV) is a mosquito-transmitted virus that has caused significant public health concerns around the world, partly because of an association with microcephaly in babies born to mothers who were infected with ZIKV during pregnancy.
Externí odkaz:
https://doaj.org/article/4e35e85d843745a6aaa67e93bac3f2e8
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Cyclic AMP (cAMP) inducible transcription factor cAMP responsive element binding protein 3 like 1 (Creb3l1) is strongly activated in the hypothalamus in response to hyperosmotic cues such as dehydration (DH). We have recently shown that Creb3l1 expre
Externí odkaz:
https://doaj.org/article/0782b9d5f599449da71098912a1529ca
Publikováno v:
eLife, Vol 4 (2015)
In response to an osmotic challenge, the synthesis of the antidiuretic hormone arginine vasopressin (AVP) increases in the hypothalamus, and this is accompanied by extension of the 3′ poly(A) tail of the AVP mRNA, and the up-regulation of the expre
Externí odkaz:
https://doaj.org/article/2850447c01b0476aa8395b5192ac7444
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124956 (2015)
Arginine vasopressin (AVP) is synthesised in magnocellular neurons (MCNs) of supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus. In response to the hyperosmotic stressors of dehydration (complete fluid deprivation, DH) or
Externí odkaz:
https://doaj.org/article/9ff386b7796248278298d781d71b4fa4
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104802 (2014)
Salt appetite, the primordial instinct to favorably ingest salty substances, represents a vital evolutionary important drive to successfully maintain body fluid and electrolyte homeostasis. This innate instinct was shown here in Sprague-Dawley rats b
Externí odkaz:
https://doaj.org/article/a7f067b1032840cd849ed161e0a871b5
Autor:
Ghadir Elsamad, Andre Mecawi, Audrys Pauža, Benjamin Gillard, Alex Paterson, Victor Duque, Olivera Šarenac, Nina Žigon, Mingkwan Greenwood, Michael Greenwood, David Murphy
Ageing is associated with altered neuroendocrine function. In the context of the hypothalamic supraoptic nucleus, which makes the antidiuretic hormone vasopressin, ageing alters acute responses to hyperosmotic cues, rendering the elderly more suscept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd624989262ac0788c06129d1e758b1a
https://doi.org/10.21203/rs.3.rs-2463463/v1
https://doi.org/10.21203/rs.3.rs-2463463/v1
Autor:
Soledad Bárez-López, Agnieszka Konopacka, Stephen J. Cross, Mingkwan Greenwood, Marina Skarveli, David Murphy, Michael P. Greenwood
Publikováno v:
Bárez-López, S, Konopacka, A, Cross, S J, Greenwood, M, Skarveli, M, Murphy, D & Greenwood, M P 2022, ' Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2 ', Neuroendocrinology, vol. 112, no. 11, pp. 1058-1077 . https://doi.org/10.1159/000522088
Introduction: Water homoeostasis is achieved by secretion of the peptide hormones arginine vasopressin (AVP) and oxytocin (OXT) that are synthesized by separate populations of magnocellular neurones (MCNs) in the supraoptic and paraventricular (PVN)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3e1b733a3f66768d4ee37f950eaaf8
https://research-information.bris.ac.uk/en/publications/bb2c3e4e-49f2-4b5d-b701-5dba0f8ae220
https://research-information.bris.ac.uk/en/publications/bb2c3e4e-49f2-4b5d-b701-5dba0f8ae220
Autor:
Mingkwan Greenwood, Michael P Greenwood, Alex Paterson, Audrys G. Pauža, André S. Mecawi, David Murphy, Charles C.T. Hindmarch
Publikováno v:
Journal of Neuroendocrinology. 33
The hypothalamic supraoptic nucleus (SON) is a core osmoregulatory control centre that deciphers information about the metabolic state of the organism and orchestrates appropriate homeostatic (endocrine) and allostatic (behavioural) responses. We hav