Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Mingkun Lu"'
Autor:
Lingyan Zheng, Shuiyang Shi, Mingkun Lu, Pan Fang, Ziqi Pan, Hongning Zhang, Zhimeng Zhou, Hanyu Zhang, Minjie Mou, Shijie Huang, Lin Tao, Weiqi Xia, Honglin Li, Zhenyu Zeng, Shun Zhang, Yuzong Chen, Zhaorong Li, Feng Zhu
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Protein function annotation has been one of the longstanding issues in biological sciences, and various computational methods have been developed. However, the existing methods suffer from a serious long-tail problem, with a large number of
Externí odkaz:
https://doaj.org/article/e654abfe23f9473fa0b7b7f2b439d1d8
Autor:
Mingkun Lu, Jiayi Yin, Qi Zhu, Gaole Lin, Minjie Mou, Fuyao Liu, Ziqi Pan, Nanxin You, Xichen Lian, Fengcheng Li, Hongning Zhang, Lingyan Zheng, Wei Zhang, Hanyu Zhang, Zihao Shen, Zhen Gu, Honglin Li, Feng Zhu
Publikováno v:
Engineering, Vol 27, Iss , Pp 37-69 (2023)
Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market. However, investments in a new drug often go unrewarded due to the long and complex process of drug research and development (R&
Externí odkaz:
https://doaj.org/article/c88b2068497d4c27a2c6926448529a3f
Autor:
Fengcheng Li, Jiayi Yin, Mingkun Lu, Minjie Mou, Zhaorong Li, Zhenyu Zeng, Ying Tan, Shanshan Wang, Xinyi Chu, Haibin Dai, Tingjun Hou, Su Zeng, Yuzong Chen, Feng Zhu
Publikováno v:
Nucleic Acids Research. 51:D1288-D1299
The efficacy and safety of drugs are widely known to be determined by their interactions with multiple molecules of pharmacological importance, and it is therefore essential to systematically depict the molecular atlas and pharma-information of studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abf82fd90edb7d8893fce8ffde11bee
https://doi.org/10.1093/nar/gkac813
https://doi.org/10.1093/nar/gkac813
Publikováno v:
Current Drug Metabolism. 24
Abstract: Protein transporters not only have essential functions in regulating the transport of endogenous substrates and remote communication between organs and organisms, but they also play a vital role in drug absorption, distribution, and excreti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8909d693d7c56744a1763af90bb8a45
https://doi.org/10.2174/1389200224666230523155759
https://doi.org/10.2174/1389200224666230523155759
Autor:
Lingyan Zheng, Shuiyang Shi, Pan Fang, Hongning Zhang, Ziqi Pan, Shijie Huang, Weiqi Xia, Honglin Li, Zhenyu Zeng, Shun Zhang, Yuzong Chen, Mingkun Lu, Zhaorong Li, Feng Zhu
Protein function annotation has been one of the longstanding issues, which is key for discovering drug targets and understanding physiological or pathological process. A variety of computational methods have therefore been constructed to facilitate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af819b4c8418bd4ed3f59fc6ee689e9
https://doi.org/10.1101/2023.05.13.540619
https://doi.org/10.1101/2023.05.13.540619
Publikováno v:
Briefings in Bioinformatics. 24
Doublets formed during single-cell RNA sequencing (scRNA-seq) severely affect downstream studies, such as differentially expressed gene analysis and cell trajectory inference, and limit the cellular throughput of scRNA-seq. Several doublet detection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6e0adfb691c772d3f559dd036d05055
https://doi.org/10.1093/bib/bbad104
https://doi.org/10.1093/bib/bbad104
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract The collapse column may result in failure of the surrounding rock during roadway excavation. It is of considerable importance to elucidate the failure characteristics and develop the corresponding control technologies for the surrounding roc
Externí odkaz:
https://doaj.org/article/19df029d1acf4c1d8e1854c0142596bf
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract The controlled shock wave (CSW) fracturing is an effective method for enhancing permeability of coal seam to promote gas extraction. Based on Fick’s law, Darcy’s law, the ideal gas law and the Langmuir equation, a damage-seepage-deformat
Externí odkaz:
https://doaj.org/article/a680cda943e94d20ae20e135c6ab73cc
Autor:
Fengcheng Li, Jiayi Yin, Mingkun Lu, Qingxia Yang, Zhenyu Zeng, Bing Zhang, Zhaorong Li, Yunqing Qiu, Haibin Dai, Yuzong Chen, Feng Zhu
Publikováno v:
Briefings in Bioinformatics. 23
The discovery of proper molecular signature from OMIC data is indispensable for determining biological state, physiological condition, disease etiology, and therapeutic response. However, the identified signature is reported to be highly inconsistent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c144b470741f9c089af657175ea8b891
https://doi.org/10.1093/bib/bbac253
https://doi.org/10.1093/bib/bbac253
Autor:
Ying Liu, Zhengyuan Liang, Yulin Li, Wenbin Zhu, Bingbing Feng, Wei Xu, Jianjun Fu, Panpan Wei, Mingkun Luo, Zaijie Dong
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Fish reproduction, development and growth are directly affected by temperature, investigating the regulatory mechanisms behind high temperature stress is helpful to construct a finer molecular network. In this study, we systematic
Externí odkaz:
https://doaj.org/article/eede3a65e2194c608ecd205559f29d5a