Výsledky vyhledávání - "Minghui Zhuo"

Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling

Autor: Wengang Li, Yongyou Zhang, Ming Li, Shaohui Shang, Kesong Peng, Minghui Zhuo, Wenbo Chen, Pingli Mo, Chundong Yu, Peng Guo, Xingfeng Qiu

Publikováno v: Oncogene. 39:3336-3353

Histone demethylase JMJD2D can promote gene expression by specifically demethylating H3K9me2/3. The role of JMJD2D in colitis and colitis-associated colorectal cancer (CRC) progression remains unclear. Here, we show that colonic JMJD2D is induced by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbd70948dee32feae5bb40050e3e8fd
https://doi.org/10.1038/s41388-020-1219-2

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Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression

Autor: Minghui Zhuo, Qiang Chen, Hui Zhou, Pingli Mo, Peng Guo, Chundong Yu, Xiaogang Xia, Ming Li, Wengang Li, Zhaojie Su, Yuan Deng, Xu Kong

Publikováno v: Theranostics

Background: As a histone demethylase, JMJD2D can enhance gene expression by specifically demethylating H3K9me2/3 and plays an important role in promoting colorectal cancer progression. However, its role in liver cancer remains unclear. Methods: The e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a579e8f2a2bbcb06515dfb2842dfe68
https://doi.org/10.7150/thno.45581

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Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells

Autor: Pathirennehelage Chandrasekera, Mark Perfetto, Congyu Lu, Minghui Zhuo, Harinath Bahudhanapati, Jiejing Li, Wei-Chih Chen, Pallavi Kulkarni, Laura Christian, Jun Liu, Yvette Y. Yien, Chundong Yu, Shuo Wei

Publikováno v: Journal of Biological Chemistry. 298:102225

Ephrin-B signaling has been implicated in many normal and pathological processes, including neural crest development and tumor metastasis. We showed previously that proteolysis of ephrin-B ligands by the disintegrin metalloprotease ADAM13 is necessar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a072e2d257e7128945a29572329824
https://doi.org/10.1016/j.jbc.2022.102225

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Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression

Autor: Qiang Chen, Chundong Yu, Ming Li, Yuan Deng, Minghui Zhuo, Peng Guo, Pingli Mo, Wengang Li

Publikováno v: The Journal of Biological Chemistry

Cancer stem-like cells (CSCs) contribute to the high rate of tumor heterogeneity, metastasis, therapeutic resistance, and recurrence. Histone lysine demethylase 4D (KDM4D or JMJD2D) is highly expressed in colon and liver tumors, where it promotes can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2212a60cddc3dc02b78771d23ed48186
https://pubmed.ncbi.nlm.nih.gov/33434575

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Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression

Autor: Kesong Peng, Minghui Zhuo, Ming Li, Qiang Chen, Pingli Mo, Chundong Yu

Publikováno v: Oncogene. 39(47)

Hypoxia-inducible factor 1 (HIF1) signaling pathway plays a key role in cancer progression by enhancing glycolysis through activating the transcription of glycolytic genes. JMJD2D, a histone demethylase that specifically demethylates H3K9me2/3, can p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bd4becff20cb90c9fec13fce2c7214
https://pubmed.ncbi.nlm.nih.gov/33619324

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Correction to: Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression

Autor: Kesong Peng, Qiang Chen, Minghui Zhuo, Pingli Mo, Chundong Yu, Ming Li

Publikováno v: Oncogene. 40:2336-2337

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cecfc43d854e7306b042d19e50dd014a
https://doi.org/10.1038/s41388-021-01678-9

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SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression

Autor: Wenbo Chen, Zhengrong Huang, Xiaochun Xia, Weihua Li, Chundong Yu, Xuqiang Lu, Yang Zhao, Minghui Zhuo, Jianming Xu

Publikováno v: International Journal of Biological Sciences

Goblet cell loss, which leads to the reduction of mucin secretion, is a hallmark of ulcerative colitis (UC). We previously reported that steroid receptor coactivator 3 (SRC-3), a transcriptional coactivator, contributes to host defense against Citrob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c52519edefe7d7da5ccee2d1523e71
https://pubmed.ncbi.nlm.nih.gov/30585268

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Akademický článek

Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression.

Autor: Yuan Deng¹, Ming Li², Minghui Zhuo¹, Peng Guo¹, Qiang Chen¹, Pingli Mo¹, Wengang Li² lwg11861@163.com, Chundong Yu¹ cdyu@xmu.edu.cn

Publikováno v: Journal of Biological Chemistry. Jan-Jun2021, Vol. 296, p1-15. 15p.

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Akademický článek

Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells.

Autor: Chandrasekera, Pathirennehelage¹, Perfetto, Mark^1,2,3, Congyu Lu¹, Minghui Zhuo⁴, Bahudhanapati, Harinath², Jiejing Li^2,5, Wei-Chih Chen², Kulkarni, Pallavi¹, Christian, Laura², Jun Liu⁶, Yien, Yvette Y.^1,3, Chundong Yu⁴, Shuo Wei¹ swei@udel.edu

Publikováno v: Journal of Biological Chemistry. Aug2022, Vol. 298 Issue 8, p1-11. 11p.

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