Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mingguang, Mo"'
Autor:
Yutong, Huang, Taoming, Huang, Xiaonuo, Zhen, Yali, Li, Mingguang, Mo, Deyong, Ye, Nengneng, Cheng
Publikováno v:
Die Pharmazie. 74(9)
Insulin resistance is a typical precursor and primary feature of type 2 diabetes mellitus (T2DM). Sphingomyelin (SM) is a kind of sphingolipid located in animal brain, liver, kidney and muscle. Sphingomyelin synthase 2 (SMS2) is the key enzyme in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae9fccd8fb6104a3a0b02aaedae73ccb
https://pubmed.ncbi.nlm.nih.gov/31484596
https://pubmed.ncbi.nlm.nih.gov/31484596
Autor:
Hai H. Bui, Peipei Liu, Bin Lou, Mingguang Mo, Xian-Cheng Jiang, Jibin Dong, Kenneth D. Roth, Tingbo Ding, Inamul Kabir, Deyong Ye, Yu Cao, Jiahui Hou, Yang Chen, Qi Liu
Publikováno v:
The Journal of biological chemistry. 293(47)
2-Hydroxy-oleic acid (2OHOA) is a potent anticancer drug that induces cancer cell cycle arrest and apoptosis. Previous studies have suggested that 2OHOA's anticancer effect is mediated by SMS activation in cancer cells, including A549 and U118 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353692796ac7a2d02551c7d0a0a00978
https://pubmed.ncbi.nlm.nih.gov/31152097
https://pubmed.ncbi.nlm.nih.gov/31152097
Autor:
Yechun Xu, Wei Zhang, Yiping Wang, Mingguang Mo, Xiaojing Yuan, Jianhua Shen, Wenwei Xu, Kai Wang, Lili Du, Xinde Chen
Publikováno v:
Journal of Medicinal Chemistry. 58:8529-8541
Inhibition of lipoprotein-associated phospholipase A2 (Lp-PLA2) has been suggested to be a promising therapeutic strategy for several inflammation-associated diseases, including atherosclerosis, Alzheimer's disease, and diabetic macular edema. Herein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde21ad1e33c6581b8f4d0a07f040b48
https://doi.org/10.1021/acs.jmedchem.5b01024
https://doi.org/10.1021/acs.jmedchem.5b01024
Autor:
Kai Wang, Quanxin Ma, Minli Chen, Yiping Wang, Mingguang Mo, Xinde Chen, Lili Du, Wenwei Xu, Jianhua Shen
Publikováno v:
Journal of medicinal chemistry. 59(6)
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered to be a promising therapeutic target for several inflammation-associated diseases. Herein, we describe the discovery of a series of pyrimidone derivatives as Lp-PLA2 inhibitors. Systemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29e4f500f60ff21f20b0cebdad378d4
https://pubmed.ncbi.nlm.nih.gov/26927682
https://pubmed.ncbi.nlm.nih.gov/26927682
Autor:
Caixia Ni, Deng Qishan, Mingguang Mo, Bichong Liu, Shi Qing, Yankui Sang, Zhe-Bin Zheng, Donald J. Creighton, Li Zonghe
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(21)
The zinc metalloenzyme glyoxalase I (GlxI) catalyzes the glutathione-dependent inactivation of cytotoxic methylglyoxal. Two competitive bivalent GlxI inhibitors, polyBHG2-62 (Ki=1.0 nM) and polyBHG2-54 (Ki=0.3 nM), were synthesized based on the trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7aac076d01f462387be4f731fed4aec
https://pubmed.ncbi.nlm.nih.gov/26320622
https://pubmed.ncbi.nlm.nih.gov/26320622
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(10)
This Letter reports our efforts towards the optimization of our previously identified series of imidazole and triazole derivatives that lead to the discovery of a series of orally active Lp-PLA2 inhibitors in C57 mice. These inhibitors are characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b17b41135fc41a146951951e3a026c
https://pubmed.ncbi.nlm.nih.gov/23575276
https://pubmed.ncbi.nlm.nih.gov/23575276
Autor:
Xinde Chen, Kai Wang, Wenwei Xu, Quanxin Ma, Minli Chen, Lili Du, Mingguang Mo, Yiping Wang, Jianhua Shen
Publikováno v:
Journal of Medicinal Chemistry; Mar2016, Vol. 59 Issue 6, p2674-2687, 14p
Autor:
Xinde Chen, Wenwei Xu, Kai Wang, Mingguang Mo, Wei Zhang, Lili Du, Xiaojing Yuan, Yechun Xu, Yiping Wang, Jianhua Shen
Publikováno v:
Journal of Medicinal Chemistry; Nov2015, Vol. 58 Issue 21, p8529-8541, 13p
Autor:
Bin Lou1 blou@shmu.edu.cn, Qi Liu1, Jiahui Hou1, Inamul Kabir2, Peipei Liu1, Tingbo Ding1, Jibin Dong1, Mingguang Mo1, Deyong Ye1, Yang Chen3, Bu, Hai H.4, Roth, Kenneth4, Yu Cao3 yu.cao@shsmu.edu.cn, Xian-Cheng Jiang1,2,5
Publikováno v:
Journal of Biological Chemistry. 11/23/2018, Vol. 293 Issue 47, p18328-18336. 9p.