Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Minggao Zhao"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2230-2239 (2024)
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder. Transgenic and pharmacological AD models are extensively studied to understand AD mechanisms and drug discovery. However, they are time-consuming and relatively costly, which hi
Externí odkaz:
https://doaj.org/article/5e9f6bdcc12143ca9bd401e55689314e
Autor:
Renming Fan, Aohua Deng, Ruizhuo Lin, Shuo Zhang, Caiyan Cheng, Junyan Zhuang, Yongrui Hai, Minggao Zhao, Le Yang, Gaofei Wei
Publikováno v:
MedComm, Vol 5, Iss 6, Pp n/a-n/a (2024)
Abstract Ferroptosis is an iron‐dependent cell death form that initiates lipid peroxidation (LPO) in tumors. In recent years, there has been growing interest on ferroptosis, but how to propel it forward translational medicine remains in mist. Altho
Externí odkaz:
https://doaj.org/article/1f72fe9e26cf4b11a50c98ddb6416e36
Autor:
Zhen Zhao, Shun Niu, Jun Chen, Hongtao Zhang, Lizuo Liang, Kui Xu, Chuan Dong, Chang Su, Tao Yan, Yongqiang Zhang, Hua Long, Le Yang, Minggao Zhao
Publikováno v:
Journal of Orthopaedic Translation, Vol 44, Iss , Pp 125-138 (2024)
Background: Osteoarthritis (OA) is the most common joint disease worldwide, but its cause remains unclear. Oestrogen protects against OA, but its clinical use is limited. G protein-coupled receptor 30 (GPR30) is a receptor that binds oestrogen, and G
Externí odkaz:
https://doaj.org/article/dad5d63114094377b8238b8111c2cf94
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Epigenetic mechanisms are processes that affect gene expression and cellular functions without involving changes in the DNA sequence. This abnormal or unstable expression of genes regulated by epigenetics can trigger cancer and other various diseases
Externí odkaz:
https://doaj.org/article/905fdc47b54f4c1f819aebd1fb1361c5
Autor:
Xinshang Wang, Yongli Jiang, Ban Feng, Xue Ma, Kun Zhang, Fan Yang, Zhenguo Liu, Le Yang, Jiao Yue, Liang Lu, Dake Song, Qingjuan Guo, Jingyu Qi, Xubo Li, Min Wang, Huinan Zhang, Jing Huang, Minggao Zhao, Shuibing Liu
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Hormone replacement therapy (HRT) is not recommended for treating learning and memory decline in menopausal women because it exerts adverse effects by activating classic estrogen receptors ERα and ERβ. The membrane estrogen receptor G protein-coupl
Externí odkaz:
https://doaj.org/article/0de22e0923984db389c2c56cd22dd7a7
Publikováno v:
Microorganisms, Vol 11, Iss 9, p 2139 (2023)
Shikonin, derived from the herb Lithospermum erythrorhizon (Purple Cromwell), is extensively utilized in traditional Chinese medicine as an anti-inflammatory agent; however, its effect on the intestinal flora is not yet known. Herein, we demonstrate
Externí odkaz:
https://doaj.org/article/ffe61e9f47e947a888562aec41efa5ab
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Calcium signaling is implicated in multiple processes including immune response that important in tumor progression. Kidney renal clear cell carcinoma (KIRC) is the most frequent histological type of renal cell carcinoma with up to a thir
Externí odkaz:
https://doaj.org/article/161a1880a58a46f28f5be3b6b5d4c28d
Autor:
Fan Yang, Xinshang Wang, Jingyu Qi, Kun Zhang, Yongli Jiang, Ban Feng, Tao Lv, Le Yang, Qi Yang, Minggao Zhao, Shuibing Liu, Xue Ma
Publikováno v:
Nutrients, Vol 15, Iss 1, p 38 (2022)
Depression is a frequent and serious comorbidity associated with diabetes which adversely affects prognosis and quality of life. Glucagon-like peptide-1 receptor (GLP-1R) agonists, widely used in the treatment of diabetes, are reported to exert neuro
Externí odkaz:
https://doaj.org/article/fb11658dcec54e589ce2e1afd53dd991
Autor:
Renming Fan, Aohua Deng, Bing Qi, Shuo Zhang, Ruoxi Sang, Lanxin Luo, Jiakui Gou, Yongqing Liu, Ruizhuo Lin, Minggao Zhao, Yang Liu, Le Yang, Maosheng Cheng, Gaofei Wei
Publikováno v:
Journal of Medicinal Chemistry. 66:875-889
Publikováno v:
Journal of Neurochemistry.