Výsledky vyhledávání - "Mingfeng Bai"

Akademický článek

Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer

Autor: Xin Wang, Dawei Zhang, Xiaodi Zhao, Yuanyuan Lu, Yun Zhou, Hua Han, Pei Wang, Wenyao Zhang, Boda Wang, Danxiu Li, Tianyu Cao, Mingfeng Bai

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)

Background The effectiveness of immune checkpoint inhibitors in colorectal cancer (CRC) is limited due to the low tumor neoantigen load and low immune infiltration in most microsatellite-stable (MSS) tumors. This study aimed to develop a mitochondria

Externí odkaz: https://doaj.org/article/52c9fbb4b5694771b416a02503c3e0a8

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Akademický článek

Molecular Imaging of Pancreatic Duct Adenocarcinoma Using a Type 2 Cannabinoid Receptor-Targeted Near-Infrared Fluorescent Probe

Autor: Xiaoxia Guo, Xiaoxi Ling, Fang Du, Qingbing Wang, Wei Huang, Zhongmin Wang, Xiaoyi Ding, Mingfeng Bai, Zhiyuan Wu

Publikováno v: Translational Oncology, Vol 11, Iss 5, Pp 1065-1073 (2018)

Imaging probes targeting type 2 cannabinoid receptor (CB2R) overexpressed in pancreatic duct adenocarcinoma (PDAC) tissue have the potential to improve early detection and surgical outcome of PDAC. The aim of our study was to evaluate the molecular i

Externí odkaz: https://doaj.org/article/e3e711fa859f4236b81c746a233bf3be

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Akademický článek

Axitinib overcomes multiple imatinib resistant cKIT mutations including the gatekeeper mutation T670I in gastrointestinal stromal tumors

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 11 (2019)

Background: cKIT kinase overexpression and gain-of-function mutations are the critical pathogenesis of gastrointestinal stromal tumors (GISTs). Although the multiple kinase inhibitors such as imatinib, sunitinib, and regorafenib have been approved fo

Externí odkaz: https://doaj.org/article/8e686e128b3448d784dba01366c15ced

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Akademický článek

Phosphorescence monitoring of hypoxic microenvironment in solid-tumors to evaluate chemotherapeutic effects using the hypoxia-sensitive iridium (III) coordination compound.

Autor: Yun Zeng, Yang Liu, Jin Shang, Jingwen Ma, Rong Wang, Lei Deng, Youmin Guo, Fan Zhong, Mingfeng Bai, Shaojuan Zhang, Daocheng Wu

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121293 (2015)

To utilize phosphorescence to monitor hypoxic microenvironment in solid-tumors and investigate cancer chemotherapeutic effects in vivo.A hypoxia-sensitive probe named BTP was used to monitor hypoxic microenvironment in solid-tumors. The low-dose metr

Externí odkaz: https://doaj.org/article/f2fbcef5a7674b4dab83a16968f6fe01

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Akademický článek

Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint.

Autor: James J Burston, Devi Rani Sagar, Pin Shao, Mingfeng Bai, Emma King, Louis Brailsford, Jenna M Turner, Gareth J Hathway, Andrew J Bennett, David A Walsh, David A Kendall, Aron Lichtman, Victoria Chapman

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80440 (2013)

Osteoarthritis (OA) of the joint is a prevalent disease accompanied by chronic, debilitating pain. Recent clinical evidence has demonstrated that central sensitization contributes to OA pain. An improved understanding of how OA joint pathology impact

Externí odkaz: https://doaj.org/article/1f09b3967b034c029341bbbc8f278674

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Akademický článek

Binding of NIR-conPK and NIR-6T to astrocytomas and microglial cells: evidence for a protein related to TSPO.

Autor: Michelle Sexton, Grace Woodruff, Eiron Cudaback, Faith R Kreitzer, Cong Xu, Yi Hsing Lin, Thomas Möller, Mingfeng Bai, H Charles Manning, Darryl Bornhop, Nephi Stella

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8271 (2009)

PK 11195 and DAA1106 bind with high-affinity to the translocator protein (TSPO, formerly known as the peripheral benzodiazepine receptor). TSPO expression in glial cells increases in response to cytokines and pathological stimuli. Accordingly, [(11)C

Externí odkaz: https://doaj.org/article/9ca90108e59146c69b58e47b6c415c24

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