Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Mingen Lin"'
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e28600- (2024)
The programmed death-ligand 1 (PD-L1) on the surface of tumor cells binds to the receptor programmed cell death protein 1 (PD-1) on effector T cells, thereby inhibiting the anti-tumor immune response. Immune checkpoint blockade (ICB) therapy targetin
Externí odkaz:
https://doaj.org/article/3eebf51175114ce08d05b3bd3bf9c76f
Autor:
Jing He, Mingen Lin, Xinchao Zhang, Ruonan Zhang, Tongguan Tian, Yuefan Zhou, Wenjing Dong, Yajing Yang, Xue Sun, Yue Dai, Yue Xu, Zhenru Zhang, Ming Xu, Qun-Ying Lei, Yanping Xu, Lei Lv
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Tumor development, involving both cell growth (mass accumulation) and cell proliferation, is a complex process governed by the interplay of multiple signaling pathways. TET2 mainly functions as a DNA dioxygenase, which modulates gene express
Externí odkaz:
https://doaj.org/article/f14e9dc959e64d9eb8fb2ae99ea97411
Publikováno v:
Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 91-106 (2023)
Chronic inflammation is believed to drive prostate carcinogenesis by producing reactive oxygen species or reactive nitrogen species to induce DNA damage. This effect might subsequently cause epigenetic and genomic alterations, leading to malignant tr
Externí odkaz:
https://doaj.org/article/306fbce3eb494ecb913e565b57b77c99
Autor:
Tongguan Tian, Xiao Xie, Wanwan Yi, Yuefan Zhou, Yixin Xu, Zhenxiang Wang, Junjing Zhang, Mingen Lin, Ruonan Zhang, Zhongwei Lv, Xinxing Li, Lei Lv, Yanping Xu
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113362- (2023)
Summary: Upregulation of FGL1 helps tumors escape from immune surveillance, and therapeutic antibodies targeting FGL1 have potential as another immune checkpoint inhibitor. However, the underlying mechanism of high FGL1 protein level in cancers is no
Externí odkaz:
https://doaj.org/article/8e874494170d46a084771dd379895838
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
How cancer cells evade the therapeutic effects of immune checkpoint blockade is largely unknown. Here, we report that fibrinogen-like protein 1 (FGL1), a newly identified immune checkpoint ligand, was modified by acetylation at Lys 98 in hepatocellul
Externí odkaz:
https://doaj.org/article/91b47849c39d40e8b979e8d32f804959
Autor:
Jing He, Mingen Lin, Xinchao Zhang, Ruonan Zhang, Tongguan Tian, Yuefan Zhou, Wenjing Dong, Yajing Yang, Xue Sun, Yue Dai, Yue Xu, Zhenru Zhang, Ming Xu, Qun-Ying Lei, Yanping Xu, Lei Lv
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/29dfc5f129eb43fcb2310ecd9839a26c
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-14 (2021)
Abstract Background Clear cell renal cell carcinoma (ccRCC) is still highly aggressive and lethal even with various therapeutic approaches. As the kidney is an iron metabolism-related organ, exploring and assessing the clinical value of ferroptosis,
Externí odkaz:
https://doaj.org/article/ad8c504b366d421d8760c9104538fe02
Publikováno v:
Nanoscale Advances; 1/21/2024, Vol. 6 Issue 2, p524-533, 10p
Autor:
Lei Lv, Yanping Xu, Qing Zhang, Jing Zhang, Qun-Ying Lei, Yixin Xu, Yuefan Zhou, Tongguan Tian, Yajing Yang, Mingen Lin, Wenjing Dong, Ruonan Zhang, Yunjie Jin, Jing He, Shuyan Li, Xinchao Zhang
Inactivating mutations of von Hippel–Lindau (VHL) are highly prevalent in clear cell renal cell carcinoma (ccRCC). Improved understanding of the vulnerabilities of VHL-deficient ccRCC could lead to improved treatment strategies. The activity of DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b112e67ed321506f34e0283187154ec
https://doi.org/10.1158/0008-5472.c.6513850.v1
https://doi.org/10.1158/0008-5472.c.6513850.v1
Autor:
Lei Lv, Yanping Xu, Qing Zhang, Jing Zhang, Qun-Ying Lei, Yixin Xu, Yuefan Zhou, Tongguan Tian, Yajing Yang, Mingen Lin, Wenjing Dong, Ruonan Zhang, Yunjie Jin, Jing He, Shuyan Li, Xinchao Zhang
Supplementary Data from TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01284a985446bba48b3596090de54f56
https://doi.org/10.1158/0008-5472.22431241.v1
https://doi.org/10.1158/0008-5472.22431241.v1