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The Hd0053 gene of Haemophilus ducreyi encodes an α2,3-sialyltransferase

Autor: Vireak Thon, Xi Chen, Hai Yu, Harshal A. Chokhawala, Yanhong Li, Mingchi Sun, Shengshu Huang

Publikováno v: Biochemical and Biophysical Research Communications. 361:555-560

Haemophilus ducreyi is a Gram-negative bacterium that causes chancroid, a sexually transmitted genital ulcer disease. Different lipooligosaccharide (LOS) structures have been identified from H. ducreyi strain 35000, including those sialylated glycofo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1eeb5862190990b4ce6ed408df7df9
https://doi.org/10.1016/j.bbrc.2007.07.063

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Cytidine 5‘-Monophosphate (CMP)-Induced Structural Changes in a Multifunctional Sialyltransferase from Pasteurella multocida

Autor: Mingchi Sun, Andrew J. Fisher, Harshal A. Chokhawala, Hai Yu, Xi Chen, Lisheng Ni

Publikováno v: Biochemistry. 45:2139-2148

Sialyltransferases catalyze reactions that transfer a sialic acid from CMP-sialic acid to an acceptor (a structure terminated with galactose, N-acetylgalactosamine, or sialic acid). They are key enzymes that catalyze the synthesis of sialic acid-cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf20831dd165b687b0260d61fe9fba2
https://doi.org/10.1021/bi0524013

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N-terminal 112 amino acid residues are not required for the sialyltransferase activity of Photobacterium damsela α 2,6-sialyltransferase

Autor: Ryan Henning, Harshal A. Chokhawala, Xi Chen, Yanhong Li, Mingchi Sun

Photobacterium damsela alpha2,6-sialyltransferase was cloned as N- and C- His-tagged fusion proteins with different lengths (16-497 aa or 113-497 aa). Expression and activity assays indicated that the N-terminal 112 amino acid residues of the protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af329f983267230d454a5f326dffa18d
https://europepmc.org/articles/PMC2598773/

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Highly efficient chemoenzymatic synthesis of naturally occurring and non-natural alpha-2,6-linked sialosides: a P. damsela alpha-2,6-sialyltransferase with extremely flexible donor-substrate specificity

Autor: Xi Chen, Harshal A. Chokhawala, Shengshu Huang, Haojie Zheng, Mingchi Sun, Hai Yu

Publikováno v: Angewandte Chemie (International ed. in English). 45(24)

Sialic acids are a family of α-keto acids with a 9-carbon backbone. They have been predominantly found as terminal carbohydrate units on glycoproteins and glycolipids of vertebrates or as components of capsular polysaccharides and lipooligosaccharid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc7b6960fa91210f5c6af299cdbcfbd
https://pubmed.ncbi.nlm.nih.gov/16721893

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