Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mingcheng, Qian"'
Autor:
Meng Nian, Zefeng Zhao, Yongqi Wang, Jingxuan Chen, Mingcheng Qian, Guangning Li, Xiaoan Li, Haifa Qiao, Xiaohang Yang
Background Epilepsy is a typical nervous system disorders identified by the spontaneous recurrence of seizures which injure periods of electroencephalographic activity and behavior. Traditional Chinese Medicine (TCM) herb pairs Polygala tenuifolia an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0e03a126fd0417d49768f4531409791
https://doi.org/10.21203/rs.3.rs-2698704/v1
https://doi.org/10.21203/rs.3.rs-2698704/v1
Autor:
Shuai Zhao, Bin‐Wei Lu, Ning Bao, Zi‐Jian Yin, Mingcheng Qian, Lin Cao, Min Geng, Ye Lin, Xin Chen
Publikováno v:
European Journal of Organic Chemistry. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7be93690dca3b9c90aab88e207f57009
https://doi.org/10.1002/ejoc.202201239
https://doi.org/10.1002/ejoc.202201239
Autor:
Víctor Fernández-Dueñas, Mingcheng Qian, Josep Argerich, Carolina Amaral, Martijn D.P. Risseeuw, Serge Van Calenbergh, Francisco Ciruela
Publikováno v:
Molecules, Vol 25, Iss 7, p 1532 (2020)
In recent years, new drug discovery approaches based on novel pharmacological concepts have emerged. Allosteric modulators, for example, target receptors at sites other than the orthosteric binding sites and can modulate agonist-mediated activation.
Externí odkaz:
https://doaj.org/article/dd32b6b66aa842b49e8c7a7c0ca9735a
Publikováno v:
The Journal of organic chemistry. 87(17)
A visible-light-promoted iodine-mediated homo-coupling of diazo was first described. A series of tetrasubstituted olefins were synthesized in high yields and with low to high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b075efadfa8f98df69a184815a74608
https://pubmed.ncbi.nlm.nih.gov/36001822
https://pubmed.ncbi.nlm.nih.gov/36001822
Autor:
Mingcheng Qian, Kuo Zhou, Yi Wu, Zhijie Luo, Zhekai Xiao, Jingjing Sun, Siyu Zeng, Yi Yao, Shuai Zhao, Xin Chen
Publikováno v:
ChemMedChem. 17
In this study, we designed and synthesized twelve bitopic ligands as dopamine D2 receptor (D2R) agonists. The forskolin-induced cAMP accumulation assay revealed that all the finial compounds are able to activate D2R. Furthermore, compound 11b showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5be7149f24f7e6ce34983262495ea5a
https://doi.org/10.1002/cmdc.202100681
https://doi.org/10.1002/cmdc.202100681
Publikováno v:
The Journal of organic chemistry. 86(10)
The cyclopropanation reaction of 3-diazooxindoles with arenes was first accomplished using visible-light irradiation. A series of spiro[norcaradiene-7,3'-indolin]-2'-ones were synthesized for the first time in high yields and with excellent diastereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baea241a7248a36f68e1ac773cba547
https://pubmed.ncbi.nlm.nih.gov/33871258
https://pubmed.ncbi.nlm.nih.gov/33871258
Autor:
Shuai Zhao, Xiaoying Zhou, Lijuan Hu, Xinyu Jiang, Xin Chen, Huimin Liu, Mingting Zhang, Mingcheng Qian
Publikováno v:
Chemistry & Biodiversity. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bbe5220a3447ae77dc7eaa524d037b4
https://doi.org/10.1002/cbdv.202100200
https://doi.org/10.1002/cbdv.202100200
Autor:
Lijuan Hu, Mingting Zhang, Xinyu Jiang, Huimin Liu, Xin Chen, Mingcheng Qian, Shuai Zhao, Xiaoying Zhou
Publikováno v:
Chemistry & Biodiversity. 18
In this paper, we designed and synthesized two series of matrine analogues with ring-opening in the lactam portion of the molecule. Our in vitro cytotoxicity study showed that analogue N-(3-bromophenyl)-4-((1R,3aS,3a1S,10aR)-decahydro-1H,4H-pyrido[3,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d51c59b4acc8bf5df2195f97d6c23c0
https://doi.org/10.1002/cbdv.202000979
https://doi.org/10.1002/cbdv.202000979
Autor:
Mingcheng Qian, Zhijie Luo, Wenwen Hou, Jingjing Sun, Xin Lu, Qianxi Zhang, Yi Wu, Caile Xue, Shuai Zhao, Xin Chen
Publikováno v:
Bioorganic Chemistry. 120:105588
In this study, fourteen new cholic acid (CA) derivatives were designed and synthesized, and the GloSensor cAMP accumulation assay indicated that all derivatives could activate the Takeda G protein-coupled receptor 5 (TGR5). Methylation of 7- and 12-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602e75ee2ad79fea9be0c01c6392becc
https://doi.org/10.1016/j.bioorg.2021.105588
https://doi.org/10.1016/j.bioorg.2021.105588
Autor:
Mingcheng, Qian, Adrián, Ricarte, Elise, Wouters, James A R, Dalton, Martijn D P, Risseeuw, Jesús, Giraldo, Serge, Van Calenbergh
Publikováno v:
European journal of medicinal chemistry. 212
Employing two different alkyne-modified dopamine agonists to construct bivalent compounds via click chemistry resulted in the identification of a bivalent ligand (11c) for dopamine D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5402be15cdd85f5508d97baddf3f19b
https://pubmed.ncbi.nlm.nih.gov/33450620
https://pubmed.ncbi.nlm.nih.gov/33450620