Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Mingang Hao"'
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113780- (2024)
Summary: Autophagy is a conserved cellular process, and its dysfunction is implicated in cancer and other diseases. Here, we employ an in vivo CRISPR screen targeting genes implicated in the regulation of autophagy to identify the Nsfl1c gene encodin
Externí odkaz:
https://doaj.org/article/6dfc4b6f1cdc4d1d94d34f7184103731
Autor:
Tianqi Wu, Wenfeng Wang, Guohai Shi, Mingang Hao, Yingying Wang, Mengfei Yao, Yongqiang Huang, Leilei Du, Xingming Zhang, Dingwei Ye, Xiaojie Bian, Jianhua Wang
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-17 (2022)
Abstract Prostate cancer (PCa) is a malignant tumor that seriously threatens men’s health worldwide. Recently, stromal cells in the tumor microenvironment (TME) have been reported to contribute to the progression of PCa. However, the role and mecha
Externí odkaz:
https://doaj.org/article/c3e8539d8a3848eba992d209cd90a08e
Autor:
Kangqiang Qiu, Weiwei Zou, Hongbao Fang, Mingang Hao, Kritika Mehta, Zhiqi Tian, Jun-Lin Guan, Kai Zhang, Taosheng Huang, Jiajie Diao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Existing methods can lack spatiotemporal accuracy to manipulate dynamic mitochondrial behaviour in live cells. Here the authors report an optogenetic method to control mitochondria-lysosome contacts and induce mitochondrial fission; they use photoact
Externí odkaz:
https://doaj.org/article/61d8a4bb6e2f44eea36055e922967241
Autor:
Qixin Chen, Mingang Hao, Lei Wang, Linsen Li, Yang Chen, Xintian Shao, Zhiqi Tian, Richard A. Pfuetzner, Qing Zhong, Axel T. Brunger, Jun-Lin Guan, Jiajie Diao
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-10 (2021)
Abstract Lysosome–autophagosome fusion is critical to autophagosome maturation. Although several proteins that regulate this fusion process have been identified, the prefusion architecture and its regulation remain unclear. Herein, we show that upo
Externí odkaz:
https://doaj.org/article/230a058ef43a4035ac804112b7b18520
Autor:
Hongbao Fang, Shanshan Geng, Mingang Hao, Qixin Chen, Minglun Liu, Chunyan Liu, Zhiqi Tian, Chengjun Wang, Takanori Takebe, Jun-Lin Guan, Yuncong Chen, Zijian Guo, Weijiang He, Jiajie Diao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subcellular Zn2+ compartmentalisation is essential for cell biology. Here the authors make a turn-on fluorescent Zn2+ probe that localises to multiple organelles, and correlate its location using organelle morphology derived from structured illuminat
Externí odkaz:
https://doaj.org/article/3348302e73d1474f966b48938a84b972
Autor:
Xueqing Sun, Qing Qu, Yimin Lao, Mi Zhang, Xiaoling Yin, Huiqin Zhu, Ying Wang, Jie Yang, Jing Yi, Mingang Hao
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstracts Background Interleukin-6 (IL-6) is commonly highly secreted in the breast cancer (BrCA) microenvironment and implicated in disease development. In this study, we aimed to determine the role of the IL-6/pSTAT3/HIC1 axis in the breast cancer
Externí odkaz:
https://doaj.org/article/182681e47a304f31b7beb4a6d72f80af
Autor:
Yongguang Yang, Marissa Leonard, Zhenhua Luo, Syn Yeo, Gregory Bick, Mingang Hao, Chunmiao Cai, Mahmoud Charif, Jiang Wang, Jun-Lin Guan, Elyse E. Lower, Xiaoting Zhang
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108822- (2021)
Summary: MED1 (mediator subunit 1) co-amplifies with HER2, but its role in HER2-driven mammary tumorigenesis is still unknown. Here, we generate MED1 mammary-specific overexpression mice and cross them with mouse mammary tumor virus (MMTV)-HER2 mice.
Externí odkaz:
https://doaj.org/article/7c097196109c4077a33168b50f10e347
Autor:
Syn Kok Yeo, Xiaoting Zhu, Takako Okamoto, Mingang Hao, Cailian Wang, Peixin Lu, Long Jason Lu, Jun-Lin Guan
Publikováno v:
eLife, Vol 9 (2020)
Breast cancer stem cells (BCSCs) contribute to intra-tumoral heterogeneity and therapeutic resistance. However, the binary concept of universal BCSCs co-existing with bulk tumor cells is over-simplified. Through single-cell RNA-sequencing, we found t
Externí odkaz:
https://doaj.org/article/49ed72ea9a90402a841943f5b6061f2c
Publikováno v:
Sedimentology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2989408fe4ea8b2ce3a8e4b0c629484
https://doi.org/10.1111/sed.13106
https://doi.org/10.1111/sed.13106
Autor:
Kunwei Shen, Jianhua Wang, Yandong Shen, Junjun Liu, Lidong Zu, Yan Mao, Jinglong Wang, Xueqing Sun, Mingang Hao, Meizhong Zhao, Xiaosong Chen
PDF file - 436K, Efficacy of PI3K inhibitors on pAkt cross-talk activation on the basis of tamoxifen and everolimus treatment in MCF-7 (left) and BT474 (right) cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ecf6446eed1a4f58a9e1121bc36d54c
https://doi.org/10.1158/1541-7786.22510110
https://doi.org/10.1158/1541-7786.22510110
